Crataegus special extract WS® 1442 improves cardiac function and reduces infarct size in a rat model of prolonged coronary ischemia and reperfusion

Veveris, M. M.; Koch, E; Chatterjee, Shyam Sunder

doi:10.1016/j.lfs.2003.09.050

Cited by 84 publications

(76 citation statements)

References 24 publications

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“…There are at least three experiments showing the effect. Hawthorn extract WS 1442 significantly reduced the deterioration of contractile function and infarct size in rat myocardium exposed to prolonged ischemia and reperfusion [67]. Besides, it showed evident effect against reperfusion arrhythmias by reducing the average prevalence of malignant arrhythmias (VF + Flutter) and the average prevalence of ventricular tachycardia (VT) [68].…”

Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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Hawthorn (Crataegus oxyacantha) is a widely used Chinese herb for treatment of gastrointestinal ailments and heart problems and consumed as food. In North America, the role of treatment for heart problems dates back to 1800. Currently, evidence is accumulating from various in vivo and in vitro studies that hawthorn extracts exert a wide range of cardiovascular pharmacological properties, including antioxidant activity, positive inotropic effect, anti-inflammatory effect, anticardiac remodeling effect, antiplatelet aggregation effect, vasodilating effect, endothelial protective effect, reduction of smooth muscle cell migration and proliferation, protective effect against ischemia/reperfusion injury, antiarrhythmic effect, lipid-lowering effect and decrease of arterial blood pressure effect. On the other hand, reviews of placebo-controlled trials have reported both subjective and objective improvement in patients with mild forms of heart failure (NYHA I–III), hypertension, and hyperlipidemia. This paper discussed the underlying pharmacology mechanisms in potential cardioprotective effects and elucidated the clinical applications of Crataegus and its various extracts.

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Section: Cardiovascular Effectmentioning

confidence: 99%

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Wang

Xiong

Feng

2013

Evidence-Based Complementary and Alternative Medicine

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“…They are considered nutritious due to their content in vitamins and micronutrients and are used to treat gastro-intestinal disorders, rheumatism, heart problems and respiratory infections (Veveris et al 2004;Jarzycka et al 2013). Ripened fruits are rich in carbohydrates while unripe ones are rich in polyunsaturated fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 lg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.ARTICLE HISTORY

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“…1 Several studies demonstrate the cardiotonic effects of hawthorn extracts, which include increasing the force of myocardial contraction, enhancing coronary blood flow, improving oxygen utilization by cardiomyocytes, and prolonging the refractory period and action-potential duration in heart and papillary muscles. 3,5,6 Research has found that hawthorn can increase coronary perfusion, has a mild hypotensive effect, and antagonizes atherogenesis with a negative chronotropic effect and a positive inotropic effect on the contraction amplitude of cardiac myocytes. [7][8][9] Hawthorn has been found to reduce incidence of reperfusioninduced ventricular fibrillations, 5,10 reduce mortality rate, 5 and decrease the mean duration of arrhythmias in ischemiareperfusion animal studies.…”

Section: Hawthornmentioning

confidence: 99%

“…3,5,6 Research has found that hawthorn can increase coronary perfusion, has a mild hypotensive effect, and antagonizes atherogenesis with a negative chronotropic effect and a positive inotropic effect on the contraction amplitude of cardiac myocytes. [7][8][9] Hawthorn has been found to reduce incidence of reperfusioninduced ventricular fibrillations, 5,10 reduce mortality rate, 5 and decrease the mean duration of arrhythmias in ischemiareperfusion animal studies. 10 The area of myocardial infarction was significantly smaller in rats treated with hawthorn extract, compared with controls.…”

Section: Hawthornmentioning

confidence: 99%

The potential role of herbal medicines in the treatment of chronic stable angina pectoris: a review of key herbs, and as illustration, exploration of the Chinese herbal medicine approach

O’Brien

Vitetta²

2012

BTAT

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Herbal medicines have been used for centuries within different cultures to treat cardiovascular disease, including stable angina pectoris. However, the use of herbs varies within traditions of natural medicine, and how they are understood to work in systems such as Chinese medicine, for example, is vastly different from the pharmaceutical model that seeks to reduce herbs to their active constituents. This review first discusses, individually, key herbs used within Western, Indian, and Chinese herbalism to treat stable angina pectoris and their main active constituents and pharmacological actions. The second part of the paper then specifically explores how angina is treated traditionally with Chinese herbal medicine, a unique approach to the understanding of health and illness underpinned by philosophies and theories that describe the physiological functioning and pathological changes in the body in terms very different from those of biomedicine. A foundational account of the guiding theories of Chinese medicine is followed by a description of the cardiovascular system and the etiology and pathogenesis of angina from the Chinese medical perspective. This forms the basis for understanding the rationale for construction of Chinese herbal medicinal formulae for treating angina pectoris. The scientific evidence of the efficacy of some Chinese herbal formulae is discussed.

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Crataegus special extract WS® 1442 improves cardiac function and reduces infarct size in a rat model of prolonged coronary ischemia and reperfusion

Cited by 84 publications

References 24 publications

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Effect ofCrataegusUsage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

The potential role of herbal medicines in the treatment of chronic stable angina pectoris: a review of key herbs, and as illustration, exploration of the Chinese herbal medicine approach

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