Crassostreaxanthins A and B, novel marine carotenoids from the oyster

Fujiwara, Yasuhiro; Maoka, Takashi; Ookubo, Masahiro; Matsuno, Takao

doi:10.1016/s0040-4039(00)61240-6

Cited by 29 publications

(32 citation statements)

References 7 publications

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“…Cytotoxic carotenoids, named crassostreaxanthins A (286) and B (287) and apoalloxanthinal (288), were isolated from the oyster Crassostrea gigas (Ostreidae) (349), and apocarotenoid 292 was isolated from the marine shellfish Mytilus coruscus (350). Acetylenic carotenoids [172, 173, 289-291, 7,8-didehydro-β-cryptoxanthin (292), 6-epi-heteroxanthin (293), and 294] have been isolated from three species of Chinese freshwater corbicula clams (Corbicula japonica, C. sandai, and Corbicula sp.…”

Section: Marine and Freshwater Mollusksmentioning

confidence: 99%

Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

127

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This review is a comprehensive survey of acetylenic lipids and their derivatives, obtained from living organisms, that have anticancer activity. Acetylenic metabolites belong to a class of molecules containing triple bond(s). They are found in plants, fungi, microorganisms, and marine invertebrates. Although acetylenes are common as components of terrestrial plants, fungi, and bacteria, it is only within the last 30 years that biologically active polyacetylenes having unusual structural features have been reported from plants, cyanobacteria, algae, invertebrates, and other sources. Naturally occurring aquatic acetylenes are of particular interest since many of them display important biological activities and possess antitumor, antibacterial, antimicrobial, antifouling, antifungal, pesticidal, phototoxic, HIV-inhibitory, and immunosuppressive properties. There is no doubt that they are of great interest, especially for the medicinal and/or pharmaceutical industries. This review presents structures and describes cytotoxic and anticancer activities only for more than 300 acetylenic lipids and their derivatives isolated from living organisms.

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Section: Marine and Freshwater Mollusksmentioning

confidence: 99%

Anticancer activity of natural and synthetic acetylenic lipids

Dembitsky¹

2006

Lipids

127

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“…Reduction of 2 with NaBH 4 gave a tetrol, having absorption maxima at 405, 429, and 465 nm, suggesting the presence of a conjugated carbonyl group in a polyene chian. 19) The 1 H chemical shifts and spin-couplings of H2 to H20 and H2Ј to H20Ј in 2 were almost identical with those of (3S,4R,3ЈS,4ЈR)-curastaxanthin 20) and crassestreaxanthin A, 13) respectively. The cis configuration of 3,4-glycol was also confirmed by coupling constant of 3.5 Hz.…”

mentioning

confidence: 81%

“…13,15) In general, animals do not synthesize carotenoids de novo and those found in animals are either directly accumulated from food or partly modified through metabolic reactions. 23) The food sources of oyster are phytoplankton such as diatom and dinoflagellate.…”

Section: Structure Of New Carotenoids With a 34-dihydroxy-b B-end Grmentioning

confidence: 99%

“…13,15,16,23) Compounds 1 and 2 might be derived from mytiloxanthin and crassestreaxanthin A, respectively. Compound 3 is a trinorcarotenoid having C 37 skeletne and was a likely metabolite of peridinin, which was accumulated from dietal dinoflagellate.…”

Section: Structure Of New Carotenoids With a 34-dihydroxy-b B-end Grmentioning

confidence: 99%

“…and 8Ј-apoalloxanthinal 11) from Mytilus coruscus, mactraxanthin from Mactra chinensis, 12) crassostreaxanthin A and B from Crassostrea gigas, 13) and a series of carotenoids with a 5,6-dihydro-b-end group from Fushinus perplexus, 14) have been reported as principal carotenoids in marine shellfish.…”

mentioning

confidence: 99%

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