Craniopharyngiomas

Karavitaki, Niki; Wass, John

doi:10.1016/j.ecl.2007.10.012

Cited by 88 publications

(41 citation statements)

References 121 publications

(197 reference statements)

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“…67,93 These tumors are generally well circumscribed and rarely contain calcifications on neuroimaging. 23,45,93 Histologically they consist of mature squamous epithelium and pseudopapillae, often appearing similar to Rathke cleft cysts that have undergone squamous differentiation at their epithelial lining. 23 Macroscopically they can have solid and/or cystic components, with cystic contents that are yellow and viscous.…”

Section: Subtypes Of Craniopharyngiomamentioning

confidence: 99%

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies

Hussain¹,

Eloy²,

Carmel³

et al. 2013

JNS

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Section: Subtypes Of Craniopharyngiomamentioning

confidence: 99%

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies

Hussain¹,

Eloy²,

Carmel³

et al. 2013

JNS

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“…Patients with these tumors often present with impaired pituitary function. 33 Reported rates for anterior pituitary hormone deficits prior to any operative intervention vary from 35 to 95% for growth hormone, 38 to 82% for follicle-stimulating hormone/luteinizing hormone, 21 to 62% for corticotrophin, and 21 to 42% for thyroid-stimulating hormone. 32 Authors of large patient series have reported that between 6 and 38% of patients present with insufficient secretion of antidiuretic hormone.…”

mentioning

confidence: 99%

Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas

Campbell¹,

McGettigan

Luginbuhl

et al. 2010

FOC

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Object The expanded endoscopic approach to craniopharyngiomas has recently been described in several small case series. The authors present their experience with this technique and review the available literature. Methods Between September 2006 and September 2009, 14 patients underwent a purely endoscopic, endonasal approach for resection of newly diagnosed craniopharyngiomas. These procedures represent index surgeries; no patient had undergone previous tumor resection. A retrospective review of endocrinological and ophthalmological outcomes, extent of resection, and complication prevalence was completed. Additionally, a review of the English literature was performed to evaluate outcomes of similar endoscopic techniques for resection of craniopharyngiomas. Results Four patients (28.6%) underwent gross-total resection; near total resection or better was achieved in 9 patients (64.3%). All patients presented with some form of visual field or acuity deficit. Postoperatively, 12 patients (85.7%) experienced visual improvement, with 6 patients (42.9%) having complete visual recovery. One patient experienced worsening of her visual deficit. Visual acuity improved in 8 patients ((57.1%), while visual field defects improved in 11 (78.6%). The pituitary stalk was preserved in all cases. Eight (57.1%) of 14 patients experienced some form of anterior pituitary dysfunction postoperatively. Although 9 patients (64.3%) were documented to have either transient or permanent new diabetes insipidus immediately after surgery, at 1-month follow-up only 1 patient met clinical criteria. Five patients (35.7%) developed CSF leaks that were successfully treated by subsequent endoscopic revision. All CSF leaks occurred early in the series. Two patients (14.2%) were treated for presumed meningitis postoperatively. Conclusions The endoscopic endonasal approach is a minimally invasive alternative to open transcranial approaches for select craniopharyngiomas. Similar to previous transcranial series, rates of endocrinopathy and gross-total resection were dependent upon the adherence of the tumor capsule to the hypothalamus, pituitary stalk, and associated vasculature. A review of the literature suggests that the results of the current series are similar to other published series on this topic.

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“…16 Its estimated incidence is 13 cases per 1 million individuals/year. 11,13 The ideal method of treatment remains highly controversial. However, a gross-total resection is thought to be associated with the best outcomes regarding postsurgical recurrence-free survival.…”

Section: Discussionmentioning

confidence: 99%

Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma

Carreras¹,

Lyons

Cochrane³

2014

PED

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Visual loss following surgery for craniopharyngioma is usually the result of operative injury or tumor recurrence. The authors present the case of a 12-year-old boy who developed progressive visual field constriction 11 years after gross-total resection of a solid and cystic craniopharyngioma. No tumor recurrence was evident on multiple MRI studies, and it was only at surgical exploration that the diagnosis of optochiasmatic arachnoiditis was established. Lysis of the adhesions around the optic nerves and chiasm resulted in substantial and sustained visual improvement.

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Craniopharyngiomas

Cited by 88 publications

References 121 publications

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies

Molecular oncogenesis of craniopharyngioma: current and future strategies for the development of targeted therapies

Endocrinological and ophthalmological consequences of an initial endonasal endoscopic approach for resection of craniopharyngiomas

Delayed visual loss from optochiasmatic arachnoiditis after resection of craniopharyngioma

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