Craniopharyngeoma presenting as psychosis, disinhibition and personality change without neurological signs

Sinai, Joanne; Wong, Alex M. H.

doi:10.1034/j.1601-5215.2003.00013.x

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…Individuals in a state of hyperprolactinemia have dopamine inhibition, which may be a key path leading to cognitive decline [ 22 ]. Notably, a report introduced one patient with an elevated PRL level due to a craniopharyngiomas compression of the pituitary gland; this individual exhibited similar deficits in attention, short-term memory, naming, and visual spatial functionality [ 23 ]. Moreover, patients with prolactinomas often complain of dysfunction in their cognitive control function.…”

Section: Introductionmentioning

confidence: 99%

Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas

Chen

Cao

Liu³

et al. 2022

Brain Sciences

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The cognitive impairment of pituitary adenomas (PAs) has received increasing attention. Hyperprolactinemia and tumor mass effect are the potential causes. The aim of this study was to identify possible cognitive impairment and to further explore the correlation between these indices and prolactin (PRL) levels, based on the control of tumor size. Twenty-seven patients with prolactinomas (patient group) and twenty-six matched health control group (HC group) were enrolled in this study. All participants performed the flanker task while we continuously recorded electroencephalography data. On the behavioral performance level, patients showed a significantly slower reaction time (RT) in both flanker types. Concerning the event-related potentials level, patients elicited reduced P2 and enhanced N2 amplitudes compared with the HC group, suggesting an impairment of attentional processing (P2) and conflict monitoring (N2). Moreover, the patient group also induced lower P3 amplitudes relative to the HC group in both types, indicating that there were deficits in attentional resource allocation ability. We also found a significant correlation between the P3 amplitudes and incongruent condition RTs, as well as the subsequent PRL levels in the patient group. In conclusion, this is an innovative study that reveals the impaired cognition abilities in prolactinomas, and also proposes the possible cognitive toxicity of oversecreted PRL levels, which provides evidence for further research on the cognitive decline in PAs.

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Section: Introductionmentioning

confidence: 99%

Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas

Chen

Cao

Liu³

et al. 2022

Brain Sciences

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“…Following several case reports of cognitive impairment due to hyperprolactinemia [3][4][5] , some group studies confirmed this relationship. In one group of men, higher prolactin levels correlated negatively with cognitive function and well-being scores, and positively with scores in depression scales 6 .…”

Section: Working Memory (Symbol Span) and Auditory-verbal Working Mem...mentioning

confidence: 79%

Attention and working memory in patients with prolactinomas: a case–control study

Bala

Dziedzic

Olejnik

et al. 2022

Sci Rep

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Prolactinomas (prolactin-secreting adenomas) are the most common type of hormone-secreting pituitary tumor. Mounting evidence indicates that excess prolactin impairs cognitive function, but specific assessments of attention in patients with prolactinomas are lacking. Case–control study gathered 54 participants—27 patients with prolactinoma and 27 healthy controls. Neuropsychological assessment included a comprehensive set of diagnostic methods for the evaluation of attention and working memory. Patients showed slower information processing, expressed as a longer working time on the d2 Test of Attention and Color Trails Test (CTT-2), and lower attention-switching shown in the CTT-2 and in two subtests of the Tests of Everyday Attention (Visual Elevator), and Telephone Search While Counting. Working memory disturbances were observed in Digit Span and Symbol Span tests. A level of prolactin correlated negatively with scores in some of the neuropsychological tests measuring attentional switching (Visual Elevator), spatial screening and working memory (CTT-2), spatial working memory (Symbol Span) and auditory-verbal working memory (Digit Span backwards). There were no significant correlations between cognitive performance and tumor size. In conclusion, patients with prolactinoma suffer from impaired cognitive functions, including attention and working memory. Comprehensive neuropsychological assessment should be a permanent element of the diagnostics of this group of patients.

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“…There are various case reports of craniopharyngiomas presenting with altered mental states, including a rapidly progressive dementia, mania, catatonia and psychosis 5–8 . It is thought that psychiatric symptoms occur in craniopharyngiomas due to the lesion disrupting neural connections between the hypothalamus and the limbic system.…”

Section: Discussionmentioning

confidence: 99%

Craniopharyngioma presenting with psychiatric symptoms: a case report

Bowers

Hughes

2021

Prog Neurol Psychiatry

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Craniopharyngeoma presenting as psychosis, disinhibition and personality change without neurological signs

Cited by 7 publications

References 11 publications

Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas

Hyperprolactinemia Associated with Attentional Processing and Interference Control Impairments in Patients with Prolactinomas

Attention and working memory in patients with prolactinomas: a case–control study

Craniopharyngioma presenting with psychiatric symptoms: a case report

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