Craniomandibular System and Postural Balance after 3-Day Dry Immersion

Treffel, Loïc; Dmitrieva, L. E.; Gauquelin‐Koch, Guillemette; Custaud, Marc‐Antoine; Blanc, Stéphane; Gharib, Claude; Millet, Catherine

doi:10.1371/journal.pone.0150052

Cited by 27 publications

(26 citation statements)

References 60 publications

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“…In our DI experiment, we found significant balance-control disturbances (Treffel et al, 2016). This postural deconditioning observed after microgravity exposure could be linked to vertebral deconditioning exposed here.…”

Section: Resultsmentioning

confidence: 49%

“…The constraints elicited on the “unstable spine” at recovery could explain IVD herniation. This vertebral deconditioning observed after microgravity could lead to postural disturbances (Huang et al, 2016; Treffel et al, 2016). Further research on these relationships is needed.…”

Section: Discussionmentioning

confidence: 99%

“…We hypothesized that (1) a 3-day DI could lead to morphological changes on the spine, which could explain the vertebral deconditioning described by astronauts after space flight; (2) the disc swelling induced by simulated microgravity is explained by an increase in IVD water content; and (3) this phenomenon is likely associated with deep muscle atrophy and could lead to postural balance disturbances, as demonstrated by another team that experienced the same conditions (Treffel et al, 2016). …”

Section: Introductionmentioning

confidence: 97%

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Intervertebral Disc Swelling Demonstrated by 3D and Water Content Magnetic Resonance Analyses after a 3-Day Dry Immersion Simulating Microgravity

et al. 2016

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Background: Vertebral deconditioning is commonly experienced after space flight and simulation studies. Disc herniation is quadrupled after space flight.Purpose: The main hypothesis formulated by the authors is that microgravity results in intervertebral disc (IVD) swelling.Study Design: The aim of the study was to identify the morphological changes of the spine and their clinical consequences after simulated microgravity by 3-day dry immersion (DI). The experimental protocol was performed on 12 male volunteers using magnetic resonance imaging and spectroscopy before and after DI.Methods: All the experiment was financially supported by CNES (Centre national d'études spatiales i.e., French Space Agency).Results: We observed an increase in spine height of 1.5 ± 0.4 cm and a decrease in curvature, particularly for the lumbar region with a decrease of −4 ± 2.5°. We found a significant increase in IVD volume of +8 ± 9% at T12-L1 and +11 ± 9% at L5-S1. This phenomenon is likely associated with the increase in disc intervertebral water content (IWC), 17 ± 27%. During the 3 days in DI, 92% of the subjects developed back pain in the lumbar region below the diaphragmatic muscle. This clinical observation may be linked to the morphological changes of the spine.Conclusions: The morphological changes observed and, specifically, the disc swelling caused by increased IWC may contribute to understanding disc herniation after microgravity exposure. Our results confirmed the efficiency of the 3-day DI model to reproduce quickly the effects of microgravity on spine morphology. Our findings raise the question of the subject selection in spatial studies, especially studies about spine morphology and reconditioning programs after space flight. These results may contribute to a better understanding of the mechanisms underlying disc herniation and may serve as the basis to develop countermeasures for astronauts and to prevent IVD herniation and back pain on Earth.

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Section: Resultsmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Intervertebral Disc Swelling Demonstrated by 3D and Water Content Magnetic Resonance Analyses after a 3-Day Dry Immersion Simulating Microgravity

et al. 2016

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“…) and on jaw and cervical muscles during DI (Treffel et al . ). Using this myometer, the viscoelastic response of the muscle was evaluated by applying a brief (15 ms) mechanical impulse (force 0.4 N) on the skin surface above the muscle.…”

Section: Methodsmentioning

confidence: 97%

Early structural and functional signature of 3‐day human skeletal muscle disuse using the dry immersion model

Demangel

Treffel

et al. 2017

The Journal of Physiology

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Microgravity and hypoactivity are associated with skeletal muscle deconditioning. The decrease of muscle mass follows an exponential decay, with major changes in the first days. The purpose of the study was to dissect out the effects of a short-term 3-day dry immersion (DI) on human quadriceps muscle function and structure. The DI model, by suppressing all support zones, accurately reproduces the effects of microgravity. Twelve healthy volunteers (32 ± 5 years) completed 3 days of DI. Muscle function was investigated through maximal voluntary contraction (MVC) tests and muscle viscoelasticity. Structural experiments were performed using MRI analysis and invasive experiments on muscle fibres. Our results indicated a significant 9.1% decrease of the normalized MVC constant (P = 0.048). Contraction and relaxation modelization kinetics reported modifications related to torque generation (k = -29%; P = 0.014) and to the relaxation phase (k = +34%; P = 0.040) after 3 days of DI. Muscle viscoelasticity was also altered. From day one, rectus femoris stiffness and tone decreased by, respectively, 7.3% (P = 0.002) and 10.2% (P = 0.002), and rectus femoris elasticity decreased by 31.5% (P = 0.004) after 3 days of DI. At the cellular level, 3 days of DI translated into a significant atrophy of type I muscle fibres (-10.6 ± 12.1%, P = 0.027) and an increased proportion of hybrid, type I/IIX fibre co-expression. Finally, we report an increase (6-fold; P = 0.002) in NCAM+ muscle fibres, showing an early denervation process. This study is the first to report experiments performed in Europe investigating human short-term DI-induced muscle adaptations, and contributes to deciphering the early changes and biomarkers of skeletal muscle deconditioning.

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“…The smaller the COP path length or sway area, the better the stability. The velocity (i.e., COP path length divided by trial duration) represents the amount of activity required to maintain stability; the smaller the COP velocity, the better the postural control (Treffel et al, 2016).…”

Section: Test Proceduresmentioning

confidence: 99%

Muscle Mechanography: A Novel Method to Measure Muscle Function in Older Adults

Taani¹,

Kovach²,

Buehring³

2017

Research in Gerontological Nursing

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Muscle function decline is a commonly observed process that occurs with aging. Low muscle function, an essential component of sarcopenia, is associated with negative outcomes, including falls, fractures, and dependency. Although many tools have been developed and are used to assess muscle function in older adults, most have important limitations. Muscle mechanography is a novel method that can quantitatively assess muscle function by performing movements such as heel raises, chair rises, or jumps on a ground reaction force plate. It can also assess balance by measuring sway of the center of pressure. Muscle mechanography promises to have advantages over currently used tools, appears to have better reproducibility, and can assess a broader range of physical function—from master athletes to frail individuals. Older adults can safely perform muscle mechanography measurements. Further research is needed to determine whether muscle mechanography can predict outcomes such as falls, fractures, and mortality. [Res Gerontol Nurs. 2017; 10(1):17–24.]

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Craniomandibular System and Postural Balance after 3-Day Dry Immersion

Cited by 27 publications

References 60 publications

Intervertebral Disc Swelling Demonstrated by 3D and Water Content Magnetic Resonance Analyses after a 3-Day Dry Immersion Simulating Microgravity

Intervertebral Disc Swelling Demonstrated by 3D and Water Content Magnetic Resonance Analyses after a 3-Day Dry Immersion Simulating Microgravity

Early structural and functional signature of 3‐day human skeletal muscle disuse using the dry immersion model

Muscle Mechanography: A Novel Method to Measure Muscle Function in Older Adults

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