Craniofacial morphology in individuals with increasing severity of hypodontia

Bajraktarova-Miševska, Cvetanka; Kanurkova, Lidija; Valjakova, Emilija Bajraktarova; Georgieva, Silvana; Bajraktarova, Bona; Georgiev, Zlatko; Sotirovska-Ivkovska, Ana

doi:10.5937/sejodr3-1266

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Some previous studies have reported an association between TA and craniofacial morphological patterns [16][17][18][19][20][21][22][23], including retrognathic maxilla [18], class III skeletal malocclusion [18,22], and concave profile [21]. Additionally, our recent study demonstrated that TAassociated GLI2 and GLI3 genes might play a role in the development of skeletal malocclusions [24].…”

Section: Introductionsupporting

confidence: 53%

Association between craniofacial morphological patterns and tooth agenesis-related genes

et al. 2020

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Background: The aim of the present study was to assess if genetic polymorphisms in tooth agenesis (TA)-related genes are associated with craniofacial morphological patterns. Methods: This cross-sectional, multi-center, genetic study evaluated 594 orthodontic Brazilians patients. The presence or absence of TA was determined by analysis of panoramic radiography. The patients were classified according to their skeletal malocclusion and facial growth pattern by means of digital cephalometric analysis. Genomic DNA was extracted from squamous epithelial cells of buccal mucosa and genetic polymorphisms in MSX1 (rs1042484), PAX9 (rs8004560), TGF-α (rs2902345), FGF3 (rs1893047), FGF10 (rs900379), and FGF13 (rs12838463, rs5931572, and rs5974804) were genotyped by polymerase chain reaction using TaqMan chemistry and end-point analysis. Results: Genotypes (p = 0.038) and allele (p = 0.037) distributions for the FGF3 rs1893047 were significantly different according to the skeletal malocclusion. Carrying at least one G allele increased in more than two times the chance of presenting skeletal class III malocclusion (OR = 2.21, CI 95% = 1.14-4.32; p = 0.017). There was no association between another skeletal craniofacial pattern and some polymorphism assessed in the present study. Conclusion: Our results suggest that the genetic polymorphism rs1893047 in FGF3 might contribute to variations in the craniofacial sagittal pattern.

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Section: Introductionsupporting

confidence: 53%

Association between craniofacial morphological patterns and tooth agenesis-related genes

et al. 2020

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“…Kreczi et al also observed a reduced SNB angle in the study compared to the standard value and in the group with mandibular agenesis and in the group with agenesis in the maxilla and mandible compared to the standard value [14]. Misewska et al showed statistically significant retrognathic mandible (reduced SNB angle) [18]. Taju et al obtained results demonstrating different effects of agenesis on the SNB angle value, depending on the ethnic group; they observed both a reduction and no effects of missing tooth buds on a retrusive position of the B point [21].…”

Section: Discussionmentioning

confidence: 75%

“…A comparison with the norms of the average measurements in the sagittal dimension obtained from the analysis performed in the study group showed a shortening of the mandibular body and ramus and a reduced height of the mandibular body in the anterior segment [10]. Misevska et al showed statistically significant mandibular shortening only in patients with agenesis of one to two teeth; they did not observe such changes in the group with more severe agenesis [18]. No effects of agenesis on the mandibular length were also observed by Øgaard and Krogstad, Endo et al and Zadurska et al in their studies [7,11,12,16,17].…”

Section: Discussionmentioning

confidence: 99%

Effect of Tooth Agenesis on Mandibular Morphology and Position

Jurek

Gozdowski

Czochrowska

et al. 2021

IJERPH

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Congenital missing teeth (OMIM #106600) is the most common dental abnormality. The aim of the study was to evaluate the effects of tooth agenesis on the total mandibular length, length of the mandibular body and alveolar process, and the mandibular anteroposterior position. The material was obtained from the Department of Orthodontics, Medical University of Warsaw. The study group included 116 patients aged 9–18 years with a congenital absence of at least two permanent tooth buds in the maxilla and/or mandible (mean: 6.2 teeth missing/patient). All patients were Caucasians: 68 (59%) females and 48 (41%) males. The control group included 115 patients without tooth agenesis matched with the age and gender of the study group. A cephalometric analysis was performed, and it was focused on assessing anteroposterior mandibular measurements. This assessment was based on 17 measurements (12 linear and 5 angular). Statistical analysis of the cephalometric measurements between the study group and the control group showed significant changes regarding selected mandibular measurements. Tooth agenesis does not affect the total length of the mandible and the length of the mandibular body, but it might reduce the length of the mandibular arch length and result in a more retrusive mandibular position.

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“…Skeletal, Incisor Angulations, and Soft Tissue Changes Associated with Hypodontia It was found by several studies that patients with tooth agenesis had a different craniofacial pattern when compared with patients with a normal number of teeth, [11][12][13][14][15][16] but few studies have investigated the effect of the distribution of congenitally missing teeth on the craniofacial morphology. [12][13][14][15][16][17] According to Endo et al, 17 an anterior and posterior hypodontia exerted a similar pattern on the craniofacial structures. However, skeletal and dental changes were more remarkable in patients having both anterior and posterior congenitally missing teeth.…”

Section: Resultsmentioning

confidence: 99%

“…12 It was found that as the severity of hypodontia increased there was more tendency toward developing a skeletal class III malocclusion. 13,16 According to Ogaard et al, 11 skeletal and soft tissue changes associated with hypodontia are directly related to the severity of the condition, i.e., the number of congenitally missing teeth. Patients with 10 and more congenitally missing teeth had the most notable retroclined pattern of the lower and upper incisors and, therefore, an increase in the interincisal angle.…”

Section: Resultsmentioning

confidence: 99%

Craniofacial and Oral Manifestations of Non-Syndromic Hypodontia: A Review

Khalaf

El-Kishawi

2022

European Journal of General Dentistry

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Patients with hypodontia appear to have a different craniofacial morphology as compared with controls. They tend to have more class III skeletal pattern and retroclined upper and lower soft tissue lips as a consequence of retroclined upper and lower incisors. These features are more pronounced as the severity of the hypodontia increases. In addition to changes in craniofacial and soft tissue morphology, various dental anomalies are commonly associated with hypodontia such as microdontia of the remaining dentition, anomalies in tooth shape, particularly peg-shaped upper lateral incisors, smaller root dimensions of some of the permanent teeth, and decreased maxillary and mandibular dental arch widths and lengths measurements. Other dental anomalies which are seen in association with hypodontia are taurodontism of molars, retained deciduous molars, delayed development of the permanent teeth, distoangulation of the mandibular second premolar, and infraocclusion of the deciduous molars.

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Craniofacial morphology in individuals with increasing severity of hypodontia

Cited by 7 publications

References 17 publications

Association between craniofacial morphological patterns and tooth agenesis-related genes

Association between craniofacial morphological patterns and tooth agenesis-related genes

Effect of Tooth Agenesis on Mandibular Morphology and Position

Craniofacial and Oral Manifestations of Non-Syndromic Hypodontia: A Review

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