“…Van der Woude syndrome (VWS; OMIM # 119300 ) is an autosomal dominant clefting disorder associated with lower lip pits and cleft lip and/or cleft palate ( Alade et al, 2020 ; Estevez-Arroyo et al, 2023 ; Gurpal-Chhabda and Singh-Chhabda, 2018 ). Mutations of interferon regulatory factor 6 ( IRF6 ) and grainy head like 3 ( GRHL3 ) genes have been implicated in VWS ( Estevez-Arroyo et al, 2023 ). Other oral manifestations include partial anodontia, dental transposition, supernumerary tooth, taurodontism, scissors bite, anterior crossbite, temporomandibular disorder, narrow high arched palate, and ankyloglossia ( Estevez-Arroyo et al, 2023 ).…”