Cranial nerve VI palsy as a rare initial presentation of systemic lupus erythematosus: case report and review of the literature

Saleh, Zenus; Menassa, Janine; Abbas, Ossama; Atweh, Samir; Arayssi, Thurayya

doi:10.1177/0961203309345722

Cited by 25 publications

(6 citation statements)

References 38 publications

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“…Moreover, the temporality of arthritis and AIHA with sixth cranial nerve palsy supported the diagnosis of SLE. Similar to a previous report, complete resolution of symptoms was observed within 2 weeks of steroid therapy, based on which the underlying pathogenesis of thrombotic vasculopathy in a positive lupus anticoagulant profile could be considered [ 26 ].…”

Section: Discussionsupporting

confidence: 75%

“…Only a few cases of isolated sixth cranial nerve palsy have been reported as a manifestation of SLE [ 25 , 26 ]. In this case, other conditions potentially associated with sixth cranial nerve palsy, including lymphoma, meningitis, Guillain-Barre syndrome, varicella-zoster virus, multiple sclerosis, cerebral venous sinus thrombosis, and diabetes mellitus, were excluded.…”

Section: Discussionmentioning

confidence: 99%

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Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy

2021

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy

2021

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“…The prevalence of LR palsy among SLE patients varies between 2% and 7% in other studies. [ 30 ] The slightly higher prevalence in this study may be due to the small number of SLE patients studied. LR palsy (abducent nerve palsy) is a rare manifestation of SLE whose pathogenesis is unknown but is thought to be due to either inflammation related to cytokine production or vascular lesions (vasculitis).…”

Section: Discussionmentioning

confidence: 74%

Prevalence and spectrum of eye disorders among patients with rheumatoid arthritis and systemic lupus erythematosus in a tertiary hospital in Northern Nigeria

Muhammad

Abdullahi

Pam

et al. 2022

J West Afr Coll Surg

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Purpose: The aim of this study was to determine the spectrum of eye disorders in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Materials and Methods: A cross-sectional hospital-based study was conducted among 100 consecutive patients with RA and SLE. A semi-structured questionnaire was used to obtain details of patients’ sociodemographics, type of rheumatic disease, and prescribed medications. Each patient had a detailed examination of the anterior and posterior segments of the eye. Refraction, intraocular pressure measurement, Schirmer’s test, tear breakup time, gonioscopy, and dilated fundoscopy were also done. Fundus photograph, central visual field assessment, and optical coherence tomography were done as necessary. Analysis was done with the Statistical Package for Social Sciences (SPSS) version 25. Statistical significance was set at P < 0.05. Results: A total of 100 patients consisting of 74 RA and 26 SLE patients were evaluated. The female: male ratio was 4.3: 1 for RA, and all SLE patients were females. The prevalence of eye disorders was 42% in all patients; it was 41.9% and 42.3% among RA and SLE patients, respectively. The most common eye disorders were dry eye (38), refractive errors (18), and cataract (16). The mean age of RA patients with eye disorders (52.19 ± 16.17 years) was significantly higher than those without eye disorders (42.30 ± 13.14 years) ( P = 0.005). Conclusion: Eye disorders are common in RA and SLE. Comprehensive eye examination should be done on all RA and SLE patients at diagnosis and before commencement of medications, and patients should be referred promptly for evaluation when they have eye complaints.

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“…Symptoms associated with the third and the fourth cranial nerves dysfunction are less often described [11, 12]. Cranial nerves neuropathy in the course of SLE is also rare and range between 0.5 and 1.0 % [4].…”

Section: Discussionmentioning

confidence: 99%

Vocal cords palsy in systemic lupus erythematosus patient: diagnostic and therapeutic difficulties

Leszczyński

Pawlak-Buś

2012

Rheumatol Int

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Vocal cords palsy is a rare complication in the course of systemic lupus erythematosus (SLE). A 38-year-old female patient with a history of SLE presented with chronic voice hoarseness resistant to standard treatment. High levels of antinuclear antibodies including dsDNA, Ro52, SSA, SSB were confirmed, while antiphospholipid antibodies were absent. While other causes of voice hoarseness were excluded, bilateral vocal cords palsy was diagnosed. Moreover, the patient revealed features of obvious Hashimoto thyroiditis with high levels of antithyroid antibodies and also developed a convergent squint as a result of fatigability of oculomotor muscles. Electrophysiology test of peripheral nerves detected myasthenic type nerve-muscle conduction impairment which was suspected as the cause of reported symptoms. Possible reasons for emerging signs and symptoms of neuropsychiatric systemic lupus erythematosus were discussed as well as the presence of vasculitis, neuropathy, significance of thyroiditis and coexistence of myasthenia. All that reasons of similar autoimmune background were also raised in this case report.

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Cranial nerve VI palsy as a rare initial presentation of systemic lupus erythematosus: case report and review of the literature

Cited by 25 publications

References 38 publications

Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy

Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy

Prevalence and spectrum of eye disorders among patients with rheumatoid arthritis and systemic lupus erythematosus in a tertiary hospital in Northern Nigeria

Vocal cords palsy in systemic lupus erythematosus patient: diagnostic and therapeutic difficulties

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