Cranial Nerve Noninvasive Neuromodulation: New Approach to Neurorehabilitation

Danilov, Yuri; Kaczmarek, K.A.; Skinner, Kimberly; Tyler, Marcus

doi:10.1201/b18126-51

Cited by 19 publications

(28 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The TVSS concept was commercialized by Wicab, Inc. (Middleton, WI, USA) in the form of the BrainPort Artificial Vision Device . The BrainPort transmits visual information through an electrotactile display worn on the tongue.…”

mentioning

confidence: 99%

Training Improves Vibrotactile Spatial Acuity and Intensity Discrimination on the Lower Back Using Coin Motors

et al. 2017

View full text Add to dashboard Cite

Tactile vision substitution devices are assistive technologies for the blind that redirect visual information to the tactile sense. They typically include a tactile display that conveys visual information to the skin. Two important parameters that determine the maximum information bandwidth of tactile displays are the spatial acuity of the skin, and the ability of the user to discriminate between stimulus intensities. These two parameters were investigated by determining the two-point discrimination (TPD) threshold and the just-noticeable intensity difference (JND) using coin motors on the lower back. Coin motors are eccentric rotating-mass motors that are affordable, energy-efficient, and easy to implement. The lower back was chosen because it is a discreet place to wear assistive technology. It is generally available for use, as it is usually not critically involved in activities of daily living. Rehabilitation with sensory substitution devices often requires training by professional occupational therapists, because the user needs to extract visual information from sparse information presented through an alternative channel such as the skin. In this study they determined whether short, automated training sessions of 5 min each could improve the TPD threshold and JND. It was found that 10 min of computer-assisted training improved the vibrotactile TPD threshold on the lower back by 36%, and that 18 min of training improved the just-noticeable intensity difference (JND) by 44%. It was concluded that short, automated training sessions could provide a fast and inexpensive means to improve people's basic spatial acuity and intensity discrimination skills with coin motors.

show abstract

mentioning

confidence: 99%

Training Improves Vibrotactile Spatial Acuity and Intensity Discrimination on the Lower Back Using Coin Motors

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Following artefact rejection, data were processed in order to extract activity speci c to the motor task. The analysis focused on activity in the beta range (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30). In order to identify the speci c beta frequencies most active during TG's movements, a time-frequency analysis (time locked to the click event and averaged across trials) was performed for each recording session on the electrodes in the contralateral motor area (using a Laplacian spatial lter centered at C3 or C4).…”

Section: Eeg -Motor Functionmentioning

confidence: 99%

“…This phenomenon appears similar to wellknown processes such as long-term potentiation (LTP) and depression. Importantly, when paired with PT (and possibly other forms of intervention), synaptic plasticity may arise through activity-dependent processes to integrate adaptive changes at the molecular, cellular, regional, and systemic levels, which in turn result in a host of improvements in sensory-motor functions, cognitive functions, and behavior (17).…”

Section: Role Of Neuromodulationmentioning

confidence: 99%

“…used high-density EEG to investigate PoNS® effects and showed signi cant increases in alpha and theta signal power following a single session. Danilov et al(17) provided an in-depth review of the hypothesis for translingual stimulation inducing neuroplasticity. Through non-invasive stimulation of the trigeminal (CN-V) and facial (CN-VII) nerves, the current concept predicts excitation that leads to functional changes across a range of brain systems.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Portable neuromodulation induces neuroplasticity to re-activate motor function recovery from brain injury: A high-density MEG case study

D’Arcy¹,

Greene²,

Greene³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: In a recent high-profile case study, we used functional magnetic resonance imaging (fMRI) to monitor improvements in motor function related to neuroplasticity following rehabilitation for severe traumatic brain injury (TBI). The findings demonstrated that motor function improvements can occur years beyond current established limits. The current study extends the functional imaging investigation to characterize neuromodulation effects on neuroplasticity to further push the limits.Methods: Canadian Soldier Captain (retired) Trevor Greene (TG) survived a severe open-TBI when attacked with an axe during a 2006 combat tour in Afghanistan. TG has since continued intensive daily rehabilitation to recover motor function, experiencing an extended plateau using conventional physical therapy. To overcome this plateau, we paired translingual neurostimulation (TLNS) with the continuing rehabilitation program. Results: Combining TLNS with rehabilitation resulted in demonstrable clinical improvements along with corresponding changes in movement evoked electro-encephalography (EEG) activity. High-density magneto-encephalography (MEG) characterized cortical activation changes in corresponding beta frequency range (27Hz). MEG activation changes corresponded with reduced interhemispheric inhibition in the post-central gyri regions together with increased right superior/middle frontal activation suggesting large scale network level changes. Conclusions: The findings provide valuable insight into the potential importance of non-invasive neuromodulation to enhance neuroplasticity mechanisms for recovery beyond the perceived limits of rehabilitation.

show abstract

“…In 2011, the current BrainPort V100 Oral Electronic Vision Aid was completed (Figure 3(c)). The BrainPort V100 received the CE mark in 2013 [36] and it is since commercially available in Europe. The clinical safety/efficacy study of the BrainPort (NIH clinical trials identifier NCT01488786) [19] showed that there is minimal risk associated with the use of the BrainPort.…”

Section: Development Of the Brainport Artificial Vision Devicementioning

confidence: 99%

Visual task performance in the blind with the BrainPort V100 Vision Aid

Stronks

Mitchell

Nau

et al. 2016

Expert Review of Medical Devices

View full text Add to dashboard Cite

Introduction: The BrainPort ® V100 Vision Aid is a non-invasive assistive device for the blind based on sensory substitution. The device translates camera images into electrotactile stimuli delivered to the tongue. The BrainPort has recently received the CE mark and FDA approval and it is currently marketed to augment, rather than replace, the traditional assistive technologies such as the white cane or guide dog. Areas covered: In this work, we will review the functional studies performed to date with the BrainPort and we will highlight the critical factors that determine device performance, including the technology behind the BrainPort, the impediments to assessing device performance, and the impact of device training and rehabilitation. Expert commentary: The BrainPort enables blind people to perceive light, identify simple objects, recognize short words, localize simple objects, and detect motion and orientation of objects. To achieve this, proper rehabilitation and training regimes are crucial. ARTICLE HISTORY

show abstract

Cranial Nerve Noninvasive Neuromodulation: New Approach to Neurorehabilitation

Cited by 19 publications

References 0 publications

Training Improves Vibrotactile Spatial Acuity and Intensity Discrimination on the Lower Back Using Coin Motors

Training Improves Vibrotactile Spatial Acuity and Intensity Discrimination on the Lower Back Using Coin Motors

Portable neuromodulation induces neuroplasticity to re-activate motor function recovery from brain injury: A high-density MEG case study

Visual task performance in the blind with the BrainPort V100 Vision Aid

Contact Info

Product

Resources

About