Cranial Metastasis of Hepatocellular Carcinoma in a Female —Case Report—

Yoshida, Daizo; Chen, Mau Nan; Awaya, Sakae; Nakazawa, Shozo

doi:10.2176/nmc.33.839

Cited by 19 publications

(20 citation statements)

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“…1,5,6,8,[11][12][13][14][15][16][17][19][20][21] The rate of bone metastasis from HCC is 4.8-15.8%, with skull metastasis representing 0.5-6.1% of all bone metastases, 1) although the incidence is increasing due to the prolonged survival after treatment for the primary lesion. 6) En bloc removal of metastatic skull tumor with the attached dura is recommended, 1,10) except for tumors at the skull base.…”

Section: Discussionmentioning

confidence: 99%

“…15) However, the outcome for patients with CCC may not be satisfactory because of the malignant nature of the primary sources, even if the tumor is successfully treated. 8,15,21) Postoperative radiotherapy was applied to the whole brain in some cases 3) and only to the local lesion in others. 1,19) In any case, local and general complications associated with the spread of this disease can be avoided.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Skull Tumor From Cholangiocarcinoma-Case Report-

Miyamoto

Tatsuzawa

Sasajima

et al. 2007

Neurol. Med. Chir.(Tokyo)

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A 67-year-old female presented with a rare metastatic skull tumor from cholangiocarcinoma (CCC) manifesting as a progressive painful subcutaneous tumor. Computed tomography and magnetic resonance (MR) imaging revealed an osteolytic tumor attached to the sigmoid sinus and mastoid sinus. Mass reduction of the tumor was performed and radiotherapy applied to the postoperative cavity. The symptoms resolved following the surgical intervention. The skull metastasis from CCC appeared as heterogeneous intensity on MR imaging reflecting the honeycomb structure. Surgery should be considered to relieve symptoms and improve the patient's quality of life, if there is a low risk of morbidity or mortality. The present case indicates another metastatic pathway through the vertebral plexus in the clinical course of CCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metastatic Skull Tumor From Cholangiocarcinoma-Case Report-

Miyamoto

Tatsuzawa

Sasajima

et al. 2007

Neurol. Med. Chir.(Tokyo)

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“…He presented with a visible, localized, round subcutaneous nodules. This symptom is also most common symptom of the patient with presenting skull metastasis [7]. To date, only a few metastatic adenocarcinoma of gastrointestinal tract tumours to skull had been reported [5,16,17].…”

Section: Saj Case Reports Issn: 2375-7043mentioning

confidence: 99%

“…Parietal bone metastasis without vertebral bone metastasis from CRC is an unexpected situation. The most common presenting symptom of skull metastases is a visible, localized swelling of skull produced by growing tumor [7]. Herein, we report a case of patient with a visible, localized swelling of skull.…”

mentioning

confidence: 95%

Parietal Bone Metastasis of Rectal Adenocarcinoma as an Initial Diagnosis of Recurrence: Case Report

Kaçan¹,

Mm²,

Na³

et al. 2014

SAJ Case Reports

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Colorectal cancer (CRC) is a most common and lethal disease of the gastrointestinal tract [1]. CRC can usually spread by lymphatic and hematogenous routes. The most common metastatic sites are the regional lymph nodes, liver, lungs, and peritoneum [1]. Uncommon metastasis of CRC were described such as skin, muscles, skull and thyroid [2][3][4][5][6]. Involvement of unusual sites with metastasis frequently occurs in the presence disseminated disease. Thus, the patient presented with widespread metastasis had poor prognosis [4]. Although all types of tumors lead to metastasis to skull hematogenous route, breast cancer and lung cancers are associated with the highest rate, skull metastases of CRC are quite rare [5]. Parietal bone metastasis without vertebral bone metastasis from CRC is an unexpected situation. The most common presenting symptom of skull metastases is a visible, localized swelling of skull produced by growing tumor [7]. Herein, we report a case of patient with a visible, localized swelling of skull.A 44-year old man had diagnosed with adenocarcinoma of the rectum as a result of colonoscopic biopsy in July 2009. Fluoropyrimidine-based neoadjuvant chemoradiotherapy had performed. "Low Anterior Resection" was held in September 2009 and after surgery 4 cycles adjuvant chemotherapy had admitted. The patient was followed in remission until February 2012. He had presented with a mass approximately 6 cm in diameter located his temporoparietal region in February 2012. The mass had grown rapidly in 4 or 5 months. Because of tumour diameter and pain, he had applied to Neurosurgery Department. Magnetic resonance imaging (MRI) showed a 6.0x4.0 cm mass, extending from bottom of scalp and epidural space (Figure 1). The mass had excised with parietal bone. After histopathological evaluation of parietal bone, the diagnosis was metastatic adenocarcinoma. Immunohistochemical analysis was positive for TTF-1, CK-19, CK-20 and CDX2. The specimens were negative for PSA, CK-7, CD10, surfactant. The final diagnosis was metastatic adenocarcinoma of CRC. He applied to Medical Oncology Department in April 2012. Palliative radiotherapy was performed to parietal bone. After the radiotherapy to the parietal bone, infusional 5-fluorouracil, leucovorin, and irinotecan and bevacizumab (FOLFIRI-BEV) was planned but he refused chemotherapy. He applied to Medical Oncology Department because of neurological complaints in July 2012. After re-staging new metastatic lesions detected in lungs, brain metastasis. Bone scan revealed widespread skeletal metastasis. Palliative radiotherapy was performed to painful bone lesions. Due to poor performance status no chemotherapy applied and he had followed up with best supportive. The patient died 9 months after the diagnosis of parietal bone metastasis. The most common metastatic sites of colorectal cancer are the regional lymph nodes, liver, lung, and peritoneum. Parietal bone metastasis without vertebral bone metastasis from colorectal cancer is an unexpected situation. Herein, we report an unusua...

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“…In these regions, it constitutes one of the most frequent malignancies due to the high prevalence of hepatitis B and C. Men are 4.8 times more likely to be affected than women [57,66,69,70]. Information regarding BM from HCC is based on case reports [65,67,68,[71][72][73][74][75][76][77] and Case report with no patient series c One patient's therapy was not specified small case studies [57,66,[69][70][71]78]. The Japanese tumor register estimates that 1.2% of all BM originate from HCC [57,74].…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

Modern management of rare brain metastases in adults

et al. 2011

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Brain metastases (BM) represent the main cause of intracranial neoplasms in adults, while being relatively less common in children. Today, better treatment options of the primary malignancy lead to higher remission rates as well as prolonged stable clinical conditions. This may in part explain the increased incidence of BM. Morbidity and mortality rates in patients with malignancies deteriorate significantly in cases of metastatic involvement of the central nervous system. Nowadays, especially modern management using surgical, medical, and radiotherapeutic options for treatment of BM tends to improve survival rates and enhance quality of life. Nonetheless, almost all treatment options are considered as palliative. In this review, we outline current knowledge of the incidence, diagnostic facilities, and therapeutic management of rare BM, with consideration of the basic aspects of the primary malignancy.

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Cranial Metastasis of Hepatocellular Carcinoma in a Female —Case Report—

Cited by 19 publications

References 0 publications

Metastatic Skull Tumor From Cholangiocarcinoma-Case Report-

Metastatic Skull Tumor From Cholangiocarcinoma-Case Report-

Parietal Bone Metastasis of Rectal Adenocarcinoma as an Initial Diagnosis of Recurrence: Case Report

Modern management of rare brain metastases in adults

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