Cranial cruciate stabilitv in the rottweiler and racing greyhound: an in vitro study

Wingfield, C H; Amis, Andrew A.; Stead, A. C.; Law, H. T.

doi:10.1111/j.1748-5827.2000.tb03193.x

Cited by 16 publications

(18 citation statements)

References 7 publications

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“…The biologic components to examine include inflammation; degradation and degeneration; impaired synthesis and turnover of extracellular matrix; necrosis; and apoptosis 1–19 . The biomechanical components to examine include instability of various types and degrees; muscle weakness and dysfunction; malalignment; conformational changes; altered kinematics; and distorted joint contact areas and pressures 20–52 . Whereas many of these components have been incriminated as causes of cruciate disease, evidence is lacking especially with respect to any factor being a sole causal agent.…”

Section: What Is Cruciate Disease In Dogs?mentioning

confidence: 99%

Cranial Cruciate Ligament Disease in Dogs: Biology versus Biomechanics

Cook

2010

Veterinary Surgery

103

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The stifle joint of dogs is an organ comprised of multiple tissue types that must work in concert to maintain joint health and function. Cruciate disease in dogs is caused by a spectrum of causal and risk factors that result in a final common pathway of abnormal biomechanics and abnormal biology causing osteoarthritis, or organ failure, of the stifle and the clinical signs of lameness, pain, and limb dysfunction. It is vital to understand the components of the biologic and biomechanical pathologies to improve our understanding of cruciate disease in dogs so that we can improve preventative, diagnostic, and therapeutic strategies for our canine patients.

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Section: What Is Cruciate Disease In Dogs?mentioning

confidence: 99%

Cranial Cruciate Ligament Disease in Dogs: Biology versus Biomechanics

Cook

2010

Veterinary Surgery

103

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“…CRANIAL CRUCIATE LIGAMENT (CCL) rupture is among the leading causes of pelvic limb lameness in dogs. The cause of CCL rupture in dogs remains unclear, but degenerative, biological, mechanical, heritable, and immune‐mediated factors have been suggested to play a role in CCL disease 1–7 . It has also been proposed that tibial plateau angle (TPA) directly affects loads on the CCL in the form of cranial tibial thrust and may therefore be associated with subsequent ligamentous injury 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Tibial Tuberosity Fracture After Tibial Plateau Leveling Osteotomy in Dogs

2008

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“…Certain dog breeds such as the Labrador Retriever and Rottweiler [33] are predisposed to ACL rupture whereas other breeds such as the Greyhound are at very low risk for ligament failure [33]. Previous studies have shown inferior mechanical properties of the ACL in a high risk breed (Rottweiler) compared to a low risk breed (Greyhound) [34,35]. By examining the knees of dog breeds with divergent predisposition to ACL failure, we can investigate the intrinsic features of the ACL that might predispose to non-contact failure.…”

Section: Introductionmentioning

confidence: 99%

Metabolism and composition of the canine anterior cruciate ligament relate to differences in knee joint mechanics and predisposition to ligament rupture

Comerford

Tarlton

Innes

et al. 2005

Journal Orthopaedic Research

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Purpose: The objective of this study was to determine whether differences in the composition and metabolism of the extracellular matrix (ECM) in canine anterior cruciate ligaments (ACLs) might relate to mechanical properties of the canine knee. Variations in ACL biochemistry and knee mechanics could account for divergent predispositions to ligament rupture.Methods: Eleven knee joints were obtained from both cadaveric Labrador Retrievers (rupture predisposed) and ex-racing Greyhounds (non-rupture predisposed). Anterioposterior laxity and tensile testing determined mechanical properties of the knee joints and ACL samples respectively. The thermal properties of the collagenous matrix were determined by differential scanning calorimetry (DSC) and the biochemical properties by measuring collagen content, collagen cross-links, glycosaminoglycan (GAG) levels, matrix nietalloproteinase-2 (MMP-2), tissue inhibitors of metalloproteinase (TIMP).Results: The anterioposterior laxity was significantly greater (p = 0.04) in the Labrador Retriever knee joints, and their ACLs tended to be weaker (p = 0.06). Greater collagen turnover was demonstrated by significantly higher (p = 0.02) concentrations of pro-MMP-2, and lower enthalpy of denaturation (p = 0.05) in Labrador Retriever ACLs.Conclusions: The different metabolism of the collagenous matrix in the ACLs of dogs predisposed to rupture was related to greater knee joint laxity and lower ligament material properties (ultimate tensile stress). This may be suggestive of a link between ligament rupture and eventual knee osteoarthritis in both dogs and humans.

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Cranial cruciate stabilitv in the rottweiler and racing greyhound: an in vitro study

Cited by 16 publications

References 7 publications

Cranial Cruciate Ligament Disease in Dogs: Biology versus Biomechanics

Cranial Cruciate Ligament Disease in Dogs: Biology versus Biomechanics

Risk Factors for Tibial Tuberosity Fracture After Tibial Plateau Leveling Osteotomy in Dogs

Metabolism and composition of the canine anterior cruciate ligament relate to differences in knee joint mechanics and predisposition to ligament rupture

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