Cranial Computertomography in Children with Tuberous Sclerosis

Kuhlendahl, H; Groβ-Selbeck, G.; Doose, H; Klinge, H.; Jensen, H.-P.

doi:10.1055/s-0028-1091528

Cited by 11 publications

(4 citation statements)

References 6 publications

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“…3,4,15,22 Some did not analyze tubers in the cerebellum. Only the presence of cortical tubers in the parietal or occipital regions had a significant relationship with a history of infantile spasm.…”

Section: Discussionmentioning

confidence: 99%

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Tuberous Sclerosis Complex: Correlation of Magnetic Resonance Imaging (MRI) Findings With Comorbidities

Wong

Khong

2006

J Child Neurol

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We studied the magnetic resonance imaging (MRI) findings in a cohort of Chinese children with tuberous sclerosis complex to determine the relationship between age, sex, mental retardation, autism, epilepsy, infantile spasm, and early age at onset of seizures and the numbers and locations of tubers detected. We searched our tuberous sclerosis registry, established in 1985 (N = 44), and performed an analysis of children who had MRIs of the brain performed (n = 22). A neuroradiologist blinded to the clinical findings scored the MRIs according to the total number and site of the tubers. The following factors were analyzed: age, sex, presence of autism (n = 7), presence (n = 19) and severity of mental retardation (mild [n = 12], moderate to severe [n = 7]), presence of epilepsy (n = 21) or infantile spasm (n = 8), and age at onset of seizures less than 1 year (n = 10). There was no significant relationship between the number and site of tubers and the following factors: sex, autism, mental retardation, degree of mental retardation, epilepsy, history of infantile spasm, or age at onset of seizures less than 1 year. Only the presence of cortical tubers in the parietal regions had a significant relationship with the history of infantile spasm (P = .012). Using multiple regression analysis of all of the risk factors, only age is related to the number of tubers in the MRI (P = .047), and a history of infantile spasm is related to the presence of tubers in the parietal (P = .009) and occipital (P = .031) lobes. The associated comorbidities in tuberous sclerosis complex might be explained by more complex underlying genetic or pathologic issues rather than purely by the site of the cortical tubers. We suggest that a developmental approach, by analyzing the age at the appearance of tubers in both symptomatic and asymptomatic cases with the development of other neuropsychiatric comorbidities, should be undertaken to assess the causal relationship.

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Section: Discussionmentioning

confidence: 99%

“…Some studies used computed tomography or MRI for neuroimaging. 3,4,15,22 Some did not analyze tubers in the cerebellum. 25 Others did not use fluid-attenuated inversion recovery imaging sequences, which are more sensitive than spin echo sequences in detecting small tubers.…”

Section: Discussionmentioning

confidence: 99%

Tuberous Sclerosis Complex: Correlation of Magnetic Resonance Imaging (MRI) Findings With Comorbidities

Wong

Khong

2006

J Child Neurol

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“…(JMG, December 1979) overlooks the recognised association of autoimmune thyroiditis with abnormal chromosomal states such as Down's syndrome' and Turner's syndrome. 2 The case histories in the paper do not preclude an acquired autoimmune thyroiditis as a cause of the hypothyroidism with onset in infancy or early childhood. Hashimoto's disease may be present in young patients with lower antibody titres, and therefore low titres do not exclude the diagnosis.3 Case 4 with presentation at the age of 7 years and a bone age of 2 5 years is not 'congenital hypothyroidism'.…”

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confidence: 93%

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Rushton¹,

Shaywitz²

1980

Journal of Medical Genetics

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“…However, these clinical findings and, in addition, those which are related to the involvement of organs other than the brain and the skin may be absent during infancy and early childhood (6,8). Plain films of the skull (9,11) and CT (5) proved to be as valuable for early diagn~sis as for~onfi~a tion of suspected disease by demonstratIOn of calclficatlOns within subependymal tubers. In a few cases even areas oflow density with evidence for dysmyelination have been detected by CT (2).…”

Section: Introductionmentioning

confidence: 99%

Tuberous Sclerosis: Magnetic Imaging of the Brain

Terwey¹,

Doose²

1987

Neuropediatrics

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The results of the magnetic resonance imaging of three patients with proven tuberous sclerosis will be discussed. Cortical tubers and subcortical areas of junctional dysmyelination can be demonstrated clearly by MRI, whereas small calcifications may be missed because of low contrast if the chosen slice thickness should be too large. It is suggested that MRI should be applied to those patients with suspected tuberous sclerosis, in which CT has failed to demonstrate typical subependymal calcifications and to those in which doubts about the definite diagnosis remain. This should be done in order to improve the accuracy of genetic counselling. It may be argued that all patients with tuberous sclerosis have to be referred to MRI, because transformation of subependymal nodules into diffusely infiltrating gliomas can be detected earlier if comparison with a former MRI study is possible.

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Cranial Computertomography in Children with Tuberous Sclerosis

Cited by 11 publications

References 6 publications

Tuberous Sclerosis Complex: Correlation of Magnetic Resonance Imaging (MRI) Findings With Comorbidities

Tuberous Sclerosis Complex: Correlation of Magnetic Resonance Imaging (MRI) Findings With Comorbidities

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Tuberous Sclerosis: Magnetic Imaging of the Brain

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