Cranial bone marrow in children: assessment of normal development with MR imaging.

Okada, Yasuo; Aoki, Stephen K.; Barkovich, A. J.; Nishimura, K; Norman, David; Kjos, B O; Brasch, R C

doi:10.1148/radiology.171.1.2928520

Cited by 56 publications

(42 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the qualitative assessment of clivus bone marrow related to age, our results were different from the findings of Okada et al (1989) and Kimura et al (1990). Our percentages of graded clivus bone marrow per decade were closer to the results of Oyar et al (1996).…”

Section: Discussioncontrasting

confidence: 85%

“…2). Clivus bone marrow showing uniform low signal intensity was graded I, bone marrow consisting of mixed low and high signal intensity portions throughout the clivus was graded II, and clivus bone marrow showing high signal intensity was graded III; this grading system was used previously by Okada et al (1989), Kimura et al (1990), and Oyar et al (1996).…”

Section: Methodsmentioning

confidence: 99%

“…Because magnetic resonance (MR) imaging has been established as the most effective non-invasive technique for investigating bone marrow (Jones, 1992;Steiner et al, 1993), a number of studies have been made to determine age-related changes (i.e., conversion of red marrow, which is hematopoietically active, to yellow marrow, which is hematopoietically inactive) in normal bone marrow in different anatomic locations of the body (Dooms et al, 1985;Okada et al, 1989;Moore and Dawson, 1990;Dawson et al, 1992;Sebag et al, 1993;Zawin and Jaramillo, 1993). MR imaging is capable of detecting red-to-yellow marrow conversion and vice versa (reconversion), as well as of displaying disease conditions involving bone marrow.…”

Section: Introductionmentioning

confidence: 99%

“…To evaluate any pathology in this region, the normal signal intensity patterns according to age should be known. To establish normal patterns of distribution of red and yellow marrow in clivus bone marrow according to age and gender, Kimura et al (1990), Okada et al (1989), Oyar et al (1996), and Simonson and Kao (1992) carried out MR imaging studies in which signal intensity patterns of clivus bone marrow were evaluated qualitatively, but not quantitatively.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of qualitative and quantitative analyses of age‐related changes in clivus bone marrow on MR imaging

et al. 2003

View full text Add to dashboard Cite

Magnetic resonance (MR) imaging is capable of detecting a wide spectrum of diseases involving clivus bone marrow. To evaluate any pathology in this region, the normal MR signal intensity patterns according to age should be known. Assessment of clivus bone marrow is usually and more efficiently made visually (qualitatively) on routine MR imaging. To compare the qualitative and quantitative analyses of age-related changes in clivus bone marrow on MR imaging, midsagittal T1-weighted MR images of the clivus bone marrow were prospectively evaluated in 201 subjects. MR signal intensity patterns of clivus bone marrow were qualitatively graded from I to III according to the proportions of low and high signal intensity areas within the clivus (Grade I: predominantly hypointense, Grade III: predominantly hyperintense). Signal intensity measurements were also made from the clivus, pons, and the cerebrospinal fluid within the fourth ventricle. Grade I pattern was observed in 92% of the subjects in the first decade, whereas Grade III pattern was not seen in this decade; Grade I pattern was absent in all but one of the subjects over the age of 50. Mean values of clivus/pons and clivus/CSF signal intensity measurements gradually increased with age in both males and females. Comparison of these ratios in each gender showed statistically significant higher values for males (P < 0.05). Comparison of the qualitative and quantitative results showed that calculated mean values of intensity ratios for each grade were different from each other; however, there was an overlap of the ranges of signal intensity ratios for Grades II and III. Visual evaluation of the clivus bone marrow MR signal is validated with the quantitative assessment results. Statistically significant higher intensity ratios in males may reflect a difference between gender in the bone mineral content under the influence of sex hormones.

show abstract

Section: Discussioncontrasting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of qualitative and quantitative analyses of age‐related changes in clivus bone marrow on MR imaging

et al. 2003

View full text Add to dashboard Cite

show abstract

“…This technique was proven useful in the assessment of bone marrow pathologies and metastatic marrow diseases (18,19). Some studies utilized conventional MRI to evaluate signal characteristics of cranial marrow (14,18,(20)(21)(22). Some authors found that MRI findings could be used as predictors for distinguishing leukemic patients from normal controls, providing more accurate diagnosis (7).…”

Section: Discussionmentioning

confidence: 99%

Role of diffusion-weighted imaging for detecting bone marrow infiltration in skull in children with acute lymphoblastic leukemia

Cao

Liang

Gen³

et al. 2016

Diagn Interv Radiol

View full text Add to dashboard Cite

A biological approach to adult sex differences in skeletal indicators of childhood stress

O’Donnell

Hill

Anderson

et al. 2021

American Journal of Biological Anthropology

View full text Add to dashboard Cite

Objectives: In previous work examining the etiology of cribra orbitalia (CO) and porotic hyperostosis (PH) in a contemporary juvenile mortality sample, we noted that males had higher odds of having CO lesions than females. Here, we examine potential reasons for this pattern in greater detail. Four non-mutually exclusive mechanisms could explain the observed sex differences: (1) sex-biased mortality; (2) sexual dimorphism in immune responses; (3) sexual dimorphism in bone turnover; or (4) sexual dimorphism in marrow conversion. Subjects and methods:The sample consists of postmortem computed tomography scans and autopsy reports, field reports, and limited medical records of 488 individuals from New Mexico (203 females; 285 males) aged between 0.5 and 15 years. We used Kaplan-Meier survival analysis, predicted probabilities, and odds ratios to test each mechanism.Results: Males do not have lower survival probabilities than females, and we find no indications of sex differences in immune response. Overall, males have a higher probability of having CO or PH lesions than females. Conclusions:All results indicate that lesion formation in juveniles is influenced by some combination of sex differences in the pace of red-yellow conversion of the bone marrow and bone turnover. The preponderance of males with CO and PH likely speaks to the potential for heightened osteoblastic activity in males. We find no support for the hypotheses that sex biases in mortality or immune responses impacted lesion frequency in this sample. Sex differences in biological processes experienced by children may affect lesion formation and lesion expression in later life.

show abstract

Cranial bone marrow in children: assessment of normal development with MR imaging.

Cited by 56 publications

References 0 publications

Comparison of qualitative and quantitative analyses of age‐related changes in clivus bone marrow on MR imaging

Comparison of qualitative and quantitative analyses of age‐related changes in clivus bone marrow on MR imaging

Role of diffusion-weighted imaging for detecting bone marrow infiltration in skull in children with acute lymphoblastic leukemia

A biological approach to adult sex differences in skeletal indicators of childhood stress

Contact Info

Product

Resources

About