Cranial arachnoid membranes: Some aspects of microsurgical anatomy

Lü, Junchang; Zhu, Xianli

doi:10.1002/ca.20448

Cited by 35 publications

(7 citation statements)

References 16 publications

(21 reference statements)

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“…The same authors also provided an interesting description of the pattern of growth of craniopharyngiomas in relation to the arachnoidea around the pituitary stalk [34]. Fox also proposed the existence of a "hypophyseal cistern" [17], noting the presence of an anterior reflection of arachnoid membrane sent from the membrane of Liliequist around the pituitary stalk, as had been observed previously [3,6,30,31]. The study by Song-tao et al [40] seemed to confirm the presence of a "pituitary cistern," containing variable lengths of the pituitary stalk, formed by arachnoid trabeculae originating from the basal arachnoid membrane, the Liliequist membrane, and the medial carotid membranes.…”

Section: Discussionmentioning

confidence: 81%

The subdiaphragmatic cistern: historic and radioanatomic findings

et al. 2011

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Section: Discussionmentioning

confidence: 81%

The subdiaphragmatic cistern: historic and radioanatomic findings

et al. 2011

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“…The pattern was significantly different only for the distal thoracic and lumbar regions, where the initial protein content was much lower than after lumbar administration. 24 We should note that the position of the needle or catheter opening relative to the spinal cord (dorsally or ventrally) may influence the apparent “distance” to the cisterna magna, because the ventral LMS is relatively open and the dorsal space is crossed by multiple membranes (Figure 1), the continuity and variability of which still have not been studied in detail 48 . Our current studies in rats suggest that catheter tip position can change the initial pattern of bolus translocation very significantly 49 .…”

Section: The Anatomy Of the Lms And The Role Of The Injected Volume Imentioning

confidence: 99%

Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS

2013

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Presently, there are no effective treatments for several diseases involving the CNS, which is protected by the blood-brain, blood-CSF and blood-arachnoid barriers. Traversing any of these barriers is difficult, especially for macromolecular drugs and particulates. However, there is significant experimental evidence that large molecules can be delivered to the CNS through the cerebro-spinal fluid (CSF). The flux of the interstitial fluid in the CNS parenchyma, as well as the macro flux of CSF in the leptomeningeal space, are believed to be generally opposite to the desirable direction of CNS-targeted drug delivery. On the other hand, the available data suggest that the layer of pia mater lining the CNS surface is not continuous, and the continuity of the leptomeningeal space (LMS) with the perivascular spaces penetrating into the parenchyma provides an unexplored avenue for drug transport deep into the brain via CSF. The published data generally do not support the view that macromolecule transport from the LMS to CNS is hindered by the interstitial and CSF fluxes. The data strongly suggest that leptomeningeal transport depends on the location and volume of the administered bolus and consists of four processes: (i) pulsation-assisted convectional transport of the solutes with CSF, (ii) active “pumping” of CSF into the periarterial spaces, (iii) solute transport from the latter to and within the parenchyma, and (iv) neuronal uptake and axonal transport. The final outcome will depend on the drug molecule behavior in each of these processes, which have not been studied systematically. The data available to date suggest that many macromolecules and nanoparticles can be delivered to CNS in biologically significant amounts (>1% of the administered dose); mechanistic investigation of macromolecule and particle behavior in CSF may result in a significantly more efficient leptomeningeal drug delivery than previously thought.

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“…The posterior borders of the newly-described diencephalic-mesencephalic leaves were also seen as free border, and thus, the interpeduncular cistern could easily communicate with the crural and ambient cisterns. The mesencephalic leaf was found to have no free border [ 18 – 20 ] (Figs. 2 , 3 ).…”

Section: Gross Anatomy and Histologymentioning

confidence: 99%

The membrane of Liliequist—a safe haven in the middle of the brain. A narrative review

et al. 2020

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Background The membrane of Liliequist is one of the best-known inner arachnoid membranes and an essential intraoperative landmark when approaching the interpeduncular cistern but also an obstacle in the growth of lesions in the sellar and parasellar regions. The limits and exact anatomical description of this membrane are still unclear, as it blends into surrounding structures and joins other arachnoid membranes. Methods We performed a systematic narrative review by searching for articles describing the anatomy and the relationship of the membrane of Liliequist with surrounding structures in MEDLINE, Embase and Google Scholar. Included articles were crosschecked for missing references. Both preclinical and clinical studies were included, if they detailed the clinical relevance of the membrane of Liliequist.Results Despite a common definition of the localisation of the membrane of Liliequist, important differences exist with respect to its anatomical borders. The membrane appears to be continuous with the pontomesencephalic and pontomedullary membranes, leading to an arachnoid membrane complex around the brainstem. Furthermore, Liliequist's membrane most likely continues along the oculomotor nerve sheath in the cavernous sinus, blending into and giving rise to the carotid-oculomotor membrane. Conclusion Further standardized anatomical studies are needed to clarify the relation of the membrane of Liliequist with surrounding structures but also the anatomy of the arachnoid membranes in general. Our study supports this endeavour by identifying the knowledge hiatuses and reviewing the current knowledge base.

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Cranial arachnoid membranes: Some aspects of microsurgical anatomy

Cited by 35 publications

References 16 publications

The subdiaphragmatic cistern: historic and radioanatomic findings

The subdiaphragmatic cistern: historic and radioanatomic findings

Physiology of the Intrathecal Bolus: The Leptomeningeal Route for Macromolecule and Particle Delivery to CNS

The membrane of Liliequist—a safe haven in the middle of the brain. A narrative review

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