Cranes of the World Lawrence H. Walkinshaw

Keith, Stuart

doi:10.2307/4084759

Cited by 1 publication

(3 citation statements)

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“…Similar results were obtained from hyperthermic evaluation of particles based on biodegradable polymers. [49,50] Besides that, SAR of this sample was also calculated according to Equation (2). The sample heated using 600 A presented, due to its intrinsic physicochemical properties reported elsewhere, [51] SAR equal to 1939 W kg À1 .…”

Section: Macromolecular Symposiamentioning

confidence: 97%

“…Currently, Drug delivery systems (DDS) are gaining increasing importance. [1][2][3][4][5][6][7][8] Because they offer the possibility of a reduction in the dosing frequency, achievement of local delivery, dose reduction, side-effect reduction, and uniform drug delivery. [9][10][11] Their clinical benefits have been demonstrated by dozens of products that have already been approved for use in humans, and several types of DDS have been approved by regulatory agencies.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, Drug delivery systems (DDS) are gaining increasing importance . Because they offer the possibility of a reduction in the dosing frequency, achievement of local delivery, dose reduction, side‐effect reduction, and uniform drug delivery .…”

Section: Introductionmentioning

confidence: 99%

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Paclitaxel‐Loaded PLA/PEG/Magnetite Anticancer and Hyperthermic Agent Prepared From Materials Obtained by the Ugi's Multicomponent Reaction

Icart

Santos

Luztonó

et al. 2018

Macromolecular Symposia

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In this study, Magnetic microspheres formed by Magnetite, Paclitaxel (PCT), poly(lactic acid) (PLA), and poly(ethylene glycol) (PEG) diblock copolymers material, synthesized by the Ugi four‐component condensation reaction (UFCC), are prepared by single emulsion and solvent evaporation procedure. Prepared PCT‐loaded magnetic microspheres (PCTMMS) are characterized by magnetic induction hyperthermia (MIH), SEM, and LDS techniques. Microencapsulation process yielded PCT encapsulation efficiency (Ee) between 70 and 80%, determined by HPLC analysis of the resulting supernatant after the microencapsulation process. A kinetic study of drug release in vitro using HPLC showed a sustained and controlled release of PCT. Also, the presence of an external magnetic field speeds up the kinetic release profile of PCT. Anticancer activity of release medium against intestine cancer cell line (Caco2) is determined using the cell viability assay. PCTMMSs are able to inhibit cancer cell growth and colony formation. The main contribution of these results is to propose a new application for UFCC in the preparation of one anticancer and hyperthermic drug delivery systems (DDS) able to improve the cancer treatment and even the welfare of the patients.

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