Cranberry products in the prevention of urinary tract infections: examining the evidence

Nowack, Rainer; Birck, Rainer

doi:10.2147/btat.s62986

Cited by 5 publications

(4 citation statements)

References 75 publications

(94 reference statements)

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“…Specifically, one of the most studied procyanidin-based approaches for UTI treatment was the use of cranberry-based products (juice, powder, or nutraceuticals) due to their high title of PACs. The patients that potentially could benefit from cranberry prophylaxis include premenopausal women with frequent but mild UTIs, postmenopausal women with more severe recurrent UTIs, and children and adults with near-permanent and complicated genitourinary malformations with UTIs [ 43 ]. One of the first clinical trials that evaluated the efficacy of cranberry juice in the treatment of UTIs was performed by Avorn et.…”

Section: Proanthocyanidinsmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections

Maisto

Iannuzzo

Novellino

et al. 2023

IJMS

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Urinary tract infections (UTIs) are the second most common type of bacterial infection worldwide. UTIs are gender-specific diseases, with a higher incidence in women. This type of infection could occur in the upper part of the urogenital tract, leading to pyelonephritis and kidney infections, or in the lower part of the urinary tract, leading to less serious pathologies, mainly cystitis and urethritis. The most common etiological agent is uropathogenic E. coli (UPEC), followed by Pseudomonas aeruginosa and Proteus mirabilis. Conventional therapeutic treatment involves the use of antimicrobial agents, but due to the dramatic increase in antimicrobial resistance (AMR), this strategy has partially lost its therapeutic efficacy. For this reason, the search for natural alternatives for UTI treatment represents a current research topic. Therefore, this review summarized the results of in vitro and animal- or human-based in vivo studies aimed to assess the potential therapeutic anti-UTI effects of natural polyphenol-based nutraceuticals and foods. In particular, the main in vitro studies were reported, describing the principal molecular therapeutic targets and the mechanism of action of the different polyphenols studied. Furthermore, the results of the most relevant clinical trials for the treatment of urinary tract health were described. Future research is needed to confirm and validate the potential of polyphenols in the clinical prophylaxis of UTIs.

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Section: Proanthocyanidinsmentioning

confidence: 99%

Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections

Maisto

Iannuzzo

Novellino

et al. 2023

IJMS

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“…The AHPA Botanical Safety Handbook classifies cranberry as Safety Class I (i.e., an herb that can be safely consumed when used appropriately) [17]. One published review assessing cranberry in the prevention of UTIs reported that besides issues with palatability, there are no safety concerns [17,68]. Nevertheless, some potentially serious AEs have been reported in case reports describing the use of cranberry.…”

Section: First Authormentioning

confidence: 99%

Safety of Cranberry: Evaluation of Evidence of Kidney Stone Formation and Botanical Drug-Interactions

et al. 2021

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Cranberry is a popular ingredient in dietary supplements in the U. S. and is commonly used for preventing urinary tract infections. Because of its popularity in dietary supplements, the U. S. Pharmacopeial Convention has developed quality standards for cranberry ingredients. The purpose of this review was to determine if there are safety issues that should preclude the admission of cranberry ingredients from the development of U. S. Pharmacopeial Convention quality standards. Based on the totality of the data, the U. S. Pharmacopeial Convention concluded that cranberry ingredients are not known to be associated with serious risks to human health when consumed properly in dietary supplements and therefore were admitted for standard development. Although published clinical and animal data indicated that cranberry is not associated with serious adverse effects, interactions with warfarin and kidney stone formation were identified as potential risks. Studies have reported contradictory data regarding the role of cranberry in kidney stone formation, with some reports suggesting cranberry is associated with a reduced risk of kidney stones. Interactions with warfarin were not associated with moderate intakes of cranberry juice (240 – 480 mL). Some reports suggested that the potential for warfarin interactions requires excessive intakes of cranberry juice (1 – 2 L/day) or cranberry extracts (3000 mg/day). Cases of warfarin interactions with cranberry have mostly involved patients with serious illnesses and/or individuals taking concomitant medications. Based on these findings, the U. S. Pharmacopeial Convention concluded that the use of cautionary labeling statements regarding interactions with warfarin or kidney stone formation is not necessary in the development of quality standards for cranberry ingredients.

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“…Fresh, dried fruits and juice of Cranberries contain various components particularly flavonoids like flavonols myricetin and quercetin, which are considered a significant source of antioxidants and antiinflammatory Skrovankova [14]. Therefore, these substances act as a potent antioxidant, which could prevent and reduce infecting of the urinary tract, through its inhibitory effect on the bacterial activity that causes infections in the urinary tract Nowack [15].…”

Section: Cranberriesmentioning

confidence: 99%

Nutritional and Healthy Benefits of Fruits

Abobatta

2021

BJSTR

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Fruits, nuts, dried fruits, and fruit juice are important components for a balanced diet; it is essential part of the staple diet. Due to their benefits for healthy body and preventive effect of numerous diseases. Fruits contain different phytochemicals, dietary fiber, protein, carbohydrates, vitamins, carotenoids, flavonoids, and other components. Furthermore, nuts and dry fruits considered a precious source of energy, antioxidants components, higher vitamins content, source for numerous minerals. Daily fruits consume particularly, Date fruits, citrus fruit, pomegranate, and Cranberries, provide several advantages for the body and different metabolic processes in human body. It is play an important role in the management of diabetes mellitus, delaying infection with chronic diseases, enhancing performance of different systems and physiological processing, reducing harmful effects on human health, in addition, it is provide nutritional ingredients such as vitamins, dietary fiber, carbohydrates, minerals …etc. Higher content of fruits particularly antioxidants plays an important role in altering the metabolic processing and detoxification of different diseases particularly carcinogens and reducing the growth of tumor cells. In addition to the effects as potent antioxidants and anti-inflammatory agents, which reduce risks of the pathogenesis of cardiovascular disease by counteracting oxidative and inflammation hazards. Furthermore, there are important roles for bioactive components contents of fruits in keeping heart-healthy, preventing cardio-metabolic and non-communicable diseases through different mechanisms.

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Cranberry products in the prevention of urinary tract infections: examining the evidence

Cited by 5 publications

References 75 publications

Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections

Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections

Safety of Cranberry: Evaluation of Evidence of Kidney Stone Formation and Botanical Drug-Interactions

Nutritional and Healthy Benefits of Fruits

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