Cranberry extract–enriched diets increase NAD(P)H:quinone oxidoreductase and catalase activities in obese but not in nonobese mice

Boušová, Iva; Bártíková, Hana; Matoušková, Petra; Lněničková, Kateřina; Zappe, Lukáš; Valentová, Kateřina; Szotáková, Barbora; Martin, Jan; Skálová, Lenka

doi:10.1016/j.nutres.2015.08.002

Cited by 7 publications

(4 citation statements)

References 48 publications

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“…Since BB, BK, and BC vary in the anthocyanin composition, their effect on plasma lipids and adipose macrophage infiltration in DIO mice was different. However, no differences were found in their antioxidant capacity and anti-inflammatory potential after BB, BK, and BC administration in DIO mice [55]. …”

Section: The Role Of Anthocyanins In Obesity: Animal Studiesmentioning

confidence: 99%

“…Boušová et al [55] demonstrated that a cranberry extract- (CBE-) enriched diet differently modulated antioxidant enzymes and redox status in obese and nonobese mice. This study was designed to test the consumption of a CBE-enriched diet (2%) for 28 days and to compare the antioxidant status of nonobese and obese mice in a model with monosodium glutamate-induced obesity.…”

Section: The Role Of Anthocyanins In Obesity: Animal Studiesmentioning

confidence: 99%

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Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies

Azzini

Giacometti

Russo

2017

Oxidative Medicine and Cellular Longevity

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The natural phytochemicals present in foods, including anthocyanins, might play a role in attenuating obesity by producing a decrease in weight and adipose tissue. This review focused on current knowledge about anthocyanins' role in obesity and its related comorbidities reported in animal models and humans. We summarized their target identification and mechanism of action through several pathways and their final effects on health and well-being. Into consideration of ongoing researches, we highlighted the following key points: a healthy relationship between anthocyanin supplementation and antiobesity effects suffers of the same pros and cons evidenced when the beneficial responses to other phytochemical treatments towards different degenerative diseases have been considered; the different dosage applied in animal versus clinical studies; the complex metabolism and biotransformation to which anthocyanins and phytochemicals are subjected in the intestine and tissues; the possibility that different components present in the supplemented mixtures can interact generating antagonistic, synergistic, or additive effects difficult to predict, and the difference between prevention and therapy. The evolution of the field must seriously consider the need to establish new and adequate cellular and animal models which may, in turn, allow the design of more efficient and prevention-targeted clinical studies.

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Section: The Role Of Anthocyanins In Obesity: Animal Studiesmentioning

confidence: 99%

Section: The Role Of Anthocyanins In Obesity: Animal Studiesmentioning

confidence: 99%

Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies

Azzini

Giacometti

Russo

2017

Oxidative Medicine and Cellular Longevity

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show abstract

“…According the study conducted by Boušová et al (2015), the cranberry extract (2%) was given to obese and non-obese mice for 4 weeks. The plasma thiol content and glutathione S-transferase enzyme function were increased in both groups and, MDA content in the blood was lowered while the enzymes catalase and liver quinone oxidoreductase increased in the obese mice.…”

Section: Anthocyanin-rich Fruit and Vegetablesmentioning

confidence: 99%

Obesity-associated Pathways of Anthocyanins

et al. 2021

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Anthocyanins have a great potential for human health, as a subgroup of phenolic compounds. Interactions of anthocyanin involved in digestion and thus in obesity consist of inhibition of pancreatic lipase, regulation of lipolysis and lipogenesis, activation of an activated protein kinase enzyme, controlling of digestion hormones (leptin, insulin, ghrelin, cholecystokinin, GIP, GLP-1). Anthocyanins are the compounds that can control metabolic syndrome and obesity by ameliorating lipid metabolism, increasing energy expenditure, suppressing food intake and inhibiting lipid absorption. In addition, the interactions with other compounds during the processing and/or in the intestinal canal can change their absorption capability and bioavailability. Activation of mitogen-activated protein kinase and cyclooxygenase (COX) enzymes, inflammatory cytokines signaling, free-radical scavenging activity are among the primary functions of anthocyanins playing role in the basic metabolic pathways. Anthocyanins also interact with gut microbiota that plays a role in many metabolic pathways. In the review, the effects of anthocyanins on the obesity-associated mechanisms in the metabolism are considered and summarized under the light of recent researches.

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“…Administration of cranberry extract resulted in beneficial changes of serum oxidative stress parameters in rats treated with model pro-oxidant, carbon tetrachloride [6]. Oxidative stress-induced in rats by a high-fat cholesterol diet [7] and obesity [8] was attenuated by several weeks of consumption cranberry preparations. Clinical studies have demonstrated that cranberry products can protect against some chronic disorders by reducing cardiovascular risk factors, improving glucoregulation and endothelial function, reducing biomarkers of metabolic syndrome and downregulating inflammatory biomarkers [2,[9][10][11].…”

Section: Introductionmentioning

confidence: 95%

Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats?

et al. 2021

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The high polyphenols content of cranberry accounts for its strong antioxidant activity underlying the beneficial health effects of this fruit. Rotenone (ROT) is a specific inhibitor of mitochondrial complex I in the brain which leads to the generation of oxidative stress. To date, there are few data indicating that toxicity of ROT is not limited to the brain but can also affect other tissues. We aimed to examine whether ROT-induced oxidative stress could be counteracted by cranberry juice not only in the brain but also in the liver and kidney. Wistar rats were given the combined treatment with ROT and cranberry juice (CJ) for 35 days. Parameters of antioxidant status were determined in the organs. ROT enhanced lipid peroxidation solely in the brain. The increase in the DNA damage was noticed in all organs examined and in leukocytes. The beneficial effect of CJ on these parameters appeared only in the brain. Additionally, CJ decreased the activity of serum hepatic enzymes. The effect of CJ on antioxidant enzymes was not consistent, however, in some organs, CJ reversed changes evoked by ROT. Summing up, ROT can cause oxidative damage not only in the brain but also in other organs. CJ demonstrated a protective effect against ROT-induced toxicity.

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Cranberry extract–enriched diets increase NAD(P)H:quinone oxidoreductase and catalase activities in obese but not in nonobese mice

Cited by 7 publications

References 48 publications

Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies

Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies

Obesity-associated Pathways of Anthocyanins

Can Cranberry Juice Protect against Rotenone-Induced Toxicity in Rats?

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