CRAFTing Delivery of Membrane Proteins into Protocells using Nanodiscs
Piotr Stępień,
Sylwia Świątek,
Manuel Yamil Yusef Robles
et al.
Abstract:For the successful
generative engineering of functional artificial
cells, a convenient and controllable means of delivering membrane
proteins into membrane lipid bilayers is necessary. Here we report
a delivery system that achieves this by employing membrane protein-carrying
nanodiscs and the calcium-dependent fusion of phosphatidylserine lipid
membranes. We show that lipid nanodiscs can fuse a transported lipid
bilayer with the lipid bilayers of small unilamellar vesicles (SUVs)
or giant unilamellar vesicles … Show more
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