Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

Miao, Yang‐Bao; Xu, Ting; Gong, Ya‐Jun; Chen, A J; Zou, Liang; Jiang, Tao; Shi, Yi

doi:10.1186/s12951-023-01991-3

Cited by 9 publications

(4 citation statements)

References 163 publications

(128 reference statements)

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“…Meanwhile, synthetic counterparts span a diverse array, embracing molecules, polymers (ranging from polymers to polymer micelles and hydrogels), as well as single-molecule nanoregulators like microemulsions, shell-nucleus nanostructures, porous solids, and nanotubes. These sophisticated entities predominantly serve catalytic functions, engage in drug delivery at the nano-level, and act as biosensors [ 101 – 103 ].…”

Section: Nanoregulator Design For Dynamic Restorationmentioning

confidence: 99%

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Jiang,

Zhang,

et al. 2024

J Nanobiotechnol

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The cryopreservation and transplantation of ovarian tissue underscore its paramount importance in safeguarding reproductive capacity and ameliorating reproductive disorders. However, challenges persist in ovarian tissue cryopreservation and transplantation (OTC-T), including the risk of tissue damage and dysfunction. Consequently, there has been a compelling exploration into the realm of nanoregulators to refine and enhance these procedures. This review embarks on a meticulous examination of the intricate anatomical structure of the ovary and its microenvironment, thereby establishing a robust groundwork for the development of nanomodulators. It systematically categorizes nanoregulators and delves deeply into their functions and mechanisms, meticulously tailored for optimizing ovarian tissue cryopreservation and transplantation. Furthermore, the review imparts valuable insights into the practical applications and obstacles encountered in clinical settings associated with OTC-T. Moreover, the review advocates for the utilization of microbially derived nanomodulators as a potent therapeutic intervention in ovarian tissue cryopreservation. The progression of these approaches holds the promise of seamlessly integrating nanoregulators into OTC-T practices, thereby heralding a new era of expansive applications and auspicious prospects in this pivotal domain. Graphical Abstract

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Section: Nanoregulator Design For Dynamic Restorationmentioning

confidence: 99%

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Jiang,

Zhang,

et al. 2024

J Nanobiotechnol

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“…One of the drug administration strategies includes absorption enhancers (usually formulation ingredients) that temporarily eliminate the intestinal barrier while causing minor tissue damage, allowing medicine to enter the bloodstream or lymphatic system. [86,87] Acute epithelial damage has been linked to intestinal permeation enhancement. [88,89] However, research indicates that some enhancing substances may be able to temporarily increase intestinal drug absorption without significant damage or having any negative side effects.…”

Section: Strategies To Overcome the Disadvantagesmentioning

confidence: 99%

Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges

Lalani,

Tivari,

Jain

et al. 2024

Peptide Science

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In the realm of therapeutic peptides, tremendous progress has been achieved in the last two decades. The building block of peptides that is, ‘Amino Acid’ has been modified by various chemical modifications such as side‐chain alteration in linear peptides, cyclization, back‐bone modification, pro‐drug moiety, conjugation with heterocycles, and natural products to make peptides a foremost candidate as a therapeutic drug. Since the advent of insulin in 1922, peptides have immensely affected the development of the pharmaceutical industry giving rise to the peptide‐based drug industry. In recent years, peptides having antimicrobial, antiviral, anti‐tumor, anti‐inflammatory, anti‐aging, and antioxidant properties have developed. Also, it has now entered as a potent candidate in the field of oncology and also become a valuable tool as a radiolabeled peptide for the detection of various diseases. Generally, peptides were extracted from natural sources in the olden days, but presently work is directed towards finding alternate and sustainable ways for developing synthetic peptides. The present review covers the discussion about the historic evaluation of peptides, available effective synthetic processes, current advancements, use of bioinformatic tools, computational strategies, and the methodology to overcome the barrier for making peptides the potent candidate for the future world.

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“…The pH of the gastrointestinal (GI) tract plays a crucial role in oral drug delivery and the absorption of medications. The GI tract consists of various regions, each with a distinct pH environment [ 25 ].…”

Section: Oral Drug Deliverymentioning

confidence: 99%

Chitosan in Oral Drug Delivery Formulations: A Review

Sangnim,

Dheer,

Jangra

et al. 2023

Pharmaceutics

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Nanoformulations have become increasingly useful as drug delivery technologies in recent decades. As therapeutics, oral administration is the most common delivery method, although it is not always the most effective route because of challenges with swallowing, gastrointestinal discomfort, low solubility, and poor absorption. One of the most significant barriers that medications must overcome to exert a therapeutic effect is the impact of the first hepatic transit. Studies have shown that controlled-release systems using nanoparticles composed of biodegradable natural polymers significantly improve oral administration, which is why these materials have attracted significant attention. Chitosan possesses a wide variety of properties and functions in the pharmaceutical as well as healthcare industries. Drug encapsulation and transport within the body are two of its most important features. Moreover, chitosan can enhance drug efficacy by facilitating drug interaction with target cells. Based on its physicochemical properties, chitosan can potentially be synthesized into nanoparticles, and this review summarizes recent advances and applications of orally delivered chitosan nanoparticle interventions.

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Cracking the intestinal lymphatic system window utilizing oral delivery vehicles for precise therapy

Cited by 9 publications

References 163 publications

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

De novo design of a nanoregulator for the dynamic restoration of ovarian tissue in cryopreservation and transplantation

Review on therapeutic potential of peptides: Advancements in synthesis methods, linear and cyclic peptides, and strategies for overcoming challenges

Chitosan in Oral Drug Delivery Formulations: A Review

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