Cracking the Code: Reprogramming the Genetic Script in Prokaryotes and Eukaryotes to Harness the Power of Noncanonical Amino Acids
Cosimo Jann,
Sabrina Giofré,
Rajanya Bhattacharjee
et al.
Abstract:Over 500 natural
and synthetic amino acids have been genetically
encoded in the last two decades. Incorporating these noncanonical
amino acids into proteins enables many powerful applications, ranging
from basic research to biotechnology, materials science, and medicine.
However, major challenges remain to unleash the full potential of
genetic code expansion across disciplines. Here, we provide an overview
of diverse genetic code expansion methodologies and systems and their
final applications in prokaryotes a… Show more
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