Uncertainty quantification (UQ) due to seismic ground motions variability is an important task in riskinformed condition assessment of infrastructures. Since performing multiple dynamic analyses is computationally expensive, it is valuable to develop a series of forecasting models based on the unique ground motion characteristics. This paper discusses the application of six different machine learning techniques on forecasting the structural behavior of gravity dams. Various time-, frequency-, and intensity-dependent characteristics are extracted from ground motion signals and used in machine learning. A large set of about 2,000 real ground motions are used, each includes about 35 meta-features. The major outcome of this study is to show the applicability of meta-modeling-based UQ in seismic safety evaluation of dams. As an intermediary result, the advantages of different machine learning algorithms, as well as meta-feature selection possibility is discussed for the current dataset. This paper proposes a feasibility study to reduce the computational costs in UQ of large-scale infrastructural systems.