CPVT and Complete Atrio-Ventricular Block: The Flipside of the Same Coin

Petrungaro, Mattia; Scarà, Antonio; Borrelli, Alessio; Sciarra, Luigi

doi:10.3390/jcdd10030097

Cited by 1 publication

(1 citation statement)

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“…Approximately 50–65% of CPVT-type 1 cases are associated with RYR2 gene mutation. Petrungaro et al found that CPVT can also give cardiac rhythm disturbances and be associated with overlap syndromes with non-compact myocardium in which patient presented with atrioventricular (AV) block ( 3 ). Although, intravenous adrenaline is the first choice of pharmaceutical therapy in cardiac resuscitation, the use of adrenaline in patient with RYR2 gene receptor mutation will lead to CPVT and death.…”

Section: Introductionmentioning

confidence: 99%

RYR2 receptor gene mutation associated with catecholaminergic polymorphic ventricular tachycardia in children: a case report & literature review

Abdullah,

Ali

2024

Transl Pediatr

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Background Ryanodine receptor 2 ( RYR2 ) gene mutation causing catecholaminergic polymorphic ventricular tachycardia (CPVT) is one of the identified causes of sudden death in adults and children. Case Description We report a case of RYR2 gene mutation presented with cardiac arrest and recurrent syncopal attack with accidental finding of cardiac tumour. For the systematic review, we used four databases (Scopus, PubMed, Ovid and Google Scholar) to search articles with the terms “ RYR2 gene mutation” and “catecholaminergic polymorphic ventricular tachycardia (CPVT)”. Fourteen studies were chosen and reviewed together with our reported patient. Most of the patients presented initially with syncopal attack and developed cardiac arrest later. Some of them presented with both syncopal attack and seizures precipitated by exercise or stress. We found that 43.8% of patients shared similar variants or coding effects in RYR2 gene mutation. Demographically, the mean age at presentation is 11 years old with 53% of reported cases were male. Conclusions Refractory arrhythmias cardiac arrest not responding to adrenaline should raise the suspicion towards RYR2 gene mutations. Recognition of this condition is important as it affects the outcome of resuscitation. Untimely diagnosis of RYR2 gene mutations with appropriate use of pharmacological agents during resuscitation is important to ensure a better outcome.

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Section: Introductionmentioning

confidence: 99%