CPT1a regulates the delivery of extracellular fatty acids for cardiolipin turnover in prostate cancer cells
Nancy T Santiappillai,
Mariam F Hakeem-Sanni,
Anabel Withy
et al.
Abstract:Mitochondrial fatty acid oxidation (FAO) has been proposed to be a major bioenergetic pathway in prostate cancer. However, this concept fails to consider FAO relative to other mitochondrial substrates. Here, we found extracellular long-chain fatty acids (LCFAs), including palmitate, stearate, oleate, linoleate, linolenate, are minor sources of carbon entering the TCA cycle compared to glucose and glutamine in prostate cancer cells, despite being assimilated in the mitochondria as acyl-carnitines. In contrast, … Show more
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