Abstract:Understanding epigenetic differences that distinguish neurons and glia is of fundamental importance to the nascent field of neuroepigenetics. A recent study (Lister & Mukamel, et al., Science 2013) used genome‐wide bisulfite sequencing to survey differences in DNA methylation between these two cell types, in both humans and mice. That study minimized the importance of cell type‐specific differences in CpG methylation, claiming these are restricted to localized genomic regions, and instead emphasized that w… Show more
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