CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer

Liu, Zeyi; Zhao, Jun; Chen, Xiaofeng; Li, Wenwen; Liu, Rengyun; Li, Zhe; Liu, Xia; Peng, Xiaobei; Xu, Ke; Chen, Jun; Liu, Hongyu; Zhou, Qinghua; Zhang, Hong Tao

doi:10.1016/j.lungcan.2008.02.005

Cited by 53 publications

(63 citation statements)

References 38 publications

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“…To date, the prevalence of RASSF1A methylation is exhibited in 30-40% of NSCLC, and is mainly detected by methylation-specific PCR (MSP) analysis Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Yanagawa et al, 2007;Yang et al, 2007;Liu et al, 2008;Lin et al, 2009;Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011;. However, association of RASSF1A promoter methylation with NSCLC have mostly been investigated in studies with small sample sizes or other limitations in study design, leading to conflicting results, especially in the relationship between RASSF1A promoter methylation and clinicopathologic features among NSCLC.…”

Section: Associations Between Rassf1a Promoter Methylation and Nsclc:mentioning

confidence: 99%

“…Moreover, one was excluded as a duplicate publication . Ultimately, 19 publications met the inclusion criteria (Figure 1) Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Kim et al, 2007;Yanagawa et al, 2007;Yang et al, 2007;Liu et al, 2008;Lin et al, 2009;Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011;Li et al, 2012) and were included in the meta-analysis. Detailed characteristics of the 19 studies are listed in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Detailed characteristics of the 19 studies are listed in Table 1. Overall, 5 of the included articles were published in Chinese Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011), and the others were published in English Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Yanagawa et al, 2007;Liu et al, 2008;Li et al, 2012). The aforementioned 19 studies provided data regarding RASSF1A promoter methylation in 2063 cases of NSCLC tissues and 1184 controls of non-tumor tissues, with a total sample size of 3247 cases.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Controls were mainly matched for sex and age. Among the controls, 14 studies were autogenous (tissues from corresponding adjacent normal tissues) Toyooka et al, 2003;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Kim et al, 2007;Yanagawa et al, 2007;Liu et al, 2008;Song et al, 2011), and 5 were heterogeneous (tissues from non-cancerous respiratory diseases) (Lin et …”

Section: Study Characteristicsmentioning

confidence: 99%

“…14 studies calculated the OR of RASSF1A promoter methylation in NSCLC cases and autogenous controls Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Kim et al, 2007;Yanagawa et al, 2007;Yang et al, 2007;Liu et al, 2008;Song et al, 2011), and the other 5 studies involved heterogeneous tissue as controls Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Li et al, 2012). The OR in the autologous control subgroup was 17.69 (95%CI, 12.51-25.02; P < 0.001) and the OR in the heterogeneous control subgroup was 32.43 (95%CI, 12.44-84.53; P < 0.001) (Figure 2).…”

Section: Subgroup Analysismentioning

confidence: 99%

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Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Liu¹,

Tan²,

Guo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: RASSF1A has been reported to be a candidate tumor suppressor in non-small cell lung cancer (NSCLC). However, the association between RASSF1A promoter methylation and NSCLC remains unclear, particularly in regarding links to clinicopathologic features. Methods: Eligible studies were identified through searching PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases. Studies were pooled and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also performed to evaluate publication bias. Keywords: RAS associations domain family protein 1A -non-small cell lung cancer -methylation -odds ratio

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Section: Associations Between Rassf1a Promoter Methylation and Nsclc:mentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Subgroup Analysismentioning

confidence: 99%

See 3 more Smart Citations

Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Liu¹,

Tan²,

Guo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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DNA Methylation and Nonsmall Cell Lung Cancer

Lü

Zhang

2011

The Anatomical Record

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Lung cancer is the leading cause of cancer-related death in men and women worldwide. Owing to the scarcity of effective tools for early detection and therapy strategies, the 5-year survival rate of lung cancer is very poor. Because the accumulation of multiple genetic and/or epigenetic changes, including DNA methylation, has been suggested to contribute to development and progression of human cancers, improved understanding of the relationship between DNA methylation and lung cancer will provide new insights for identifying promising biomarkers for diagnosis, prognosis, and treatment of lung cancer. Here, we present a relatively comprehensive review of DNA methylation and lung cancer, discuss DNA methylation changes in carcinogenesis and metastasis of lung cancer, and explore the association of microRNA with DNA methylation. Additionally, we outline the applications of DNA methylation in clinical practice, such as diagnosis, prognosis, and therapy of lung cancer. Anat Rec, 294:1787Rec, 294: -1795Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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Hypermethylation of CpG islands is associated with increasing chromosomal damage in chinese lead‐exposed workers

Zhang

et al. 2018

Environ and Mol Mutagen

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Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppressor genes (TSGs) post lead exposure. In the study, 147 lead-exposed workers were divided into two groups according to their B-Pb P value, with other 50 lead-unexposed workers as a control group. The cytokinesis-blocked micronucleus (CBMN) assay was performed to detect chromosomal damage of PBLs of both lead-exposed and -unexposed workers. The methylation-specific polymerase chain reaction (MSP-PCR) was further used to examine the methylation status of six TSGs (GSTP1, hMLH1, MGMT, p14, p15, and p16). Results showed that MN frequencies of high B-Pb workers 8.1 ± 3.1‰ and low B-Pb workers 5.7 ± 2.3‰ were significantly higher than that of control group 2.8 ± 1.9‰ (P < 0.01), while the MN frequency of high B-Pb workers was also higher than that of the low B-Pb workers (P < 0.01). The MN frequency in PBLs of lead-exposed group with the methylated TSGs was significantly higher than that in PBLs with the unmethylated TSGs (P < 0.05). Notably, the CpG island methylator phenotype (CIMP) correlated with chromosome damage (P < 0.05). Additionally, workers with high B-Pb had higher chromosome damage than those with low B-Pb (P < 0.05). Taken altogether, the results suggest that lead-exposed workers with CIMP positive and high B-Pb have a higher risk of being vulnerable to tumorigenesis. Environ. Mol. Mutagen. 59:549-556, 2018. © 2018 Wiley Periodicals, Inc.

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CpG island methylator phenotype involving tumor suppressor genes located on chromosome 3p in non-small cell lung cancer

Cited by 53 publications

References 38 publications

Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

DNA Methylation and Nonsmall Cell Lung Cancer

Hypermethylation of CpG islands is associated with increasing chromosomal damage in chinese lead‐exposed workers

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