CpG island methylation and expression of tumour-associated genes in lung carcinoma

Dammann, Reinhard; Strunnikova, M.; Schagdarsurengin, Undraga; Rastetter, Matthias; Papritz, Mirko; Hattenhorst, Uwe; Hofmann, Hans‐Stefan; Silber, Rolf-Edgar; Burdach, Stefan; Hansen, Gesine

doi:10.1016/j.ejca.2005.02.020

Cited by 141 publications

(112 citation statements)

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“…The OR in the autologous control subgroup was 17.69 (95%CI, 12.51-25.02; P < 0.001) and the OR in the heterogeneous control subgroup was 32.43 (95%CI, 12.44-84.53; P < 0.001) (Figure 2). In the subgroup analysis of ethnicity, the OR for the Caucasian subgroup was 26.55 (95% CI, 10.86-64.88; P < 0.001) from 4 studies Guo et al, 2004;Wang et al, 2004;Dammann et al, 2005), for the Asian subgroup was 20.94 (95% CI, 14.41-30.43; P <0.001) from 14 studies Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Kim et al, 2007;Yanagawa et al, 2007;Yang et al, 2007;Liu et al, 2008;Lin et al, 2009;Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011;Li et al, 2012) (Figure 2).…”

Section: Subgroup Analysismentioning

confidence: 94%

“…To date, the prevalence of RASSF1A methylation is exhibited in 30-40% of NSCLC, and is mainly detected by methylation-specific PCR (MSP) analysis Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Yanagawa et al, 2007;Yang et al, 2007;Liu et al, 2008;Lin et al, 2009;Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011;. However, association of RASSF1A promoter methylation with NSCLC have mostly been investigated in studies with small sample sizes or other limitations in study design, leading to conflicting results, especially in the relationship between RASSF1A promoter methylation and clinicopathologic features among NSCLC.…”

Section: Associations Between Rassf1a Promoter Methylation and Nsclc:mentioning

confidence: 99%

“…Moreover, one was excluded as a duplicate publication . Ultimately, 19 publications met the inclusion criteria (Figure 1) Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Kim et al, 2007;Yanagawa et al, 2007;Yang et al, 2007;Liu et al, 2008;Lin et al, 2009;Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011;Li et al, 2012) and were included in the meta-analysis. Detailed characteristics of the 19 studies are listed in Table 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Detailed characteristics of the 19 studies are listed in Table 1. Overall, 5 of the included articles were published in Chinese Peng et al, 2010;Zhang et al, 2010;Kang et al, 2011;Song et al, 2011), and the others were published in English Toyooka et al, 2003;Guo et al, 2004;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Yanagawa et al, 2007;Liu et al, 2008;Li et al, 2012). The aforementioned 19 studies provided data regarding RASSF1A promoter methylation in 2063 cases of NSCLC tissues and 1184 controls of non-tumor tissues, with a total sample size of 3247 cases.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Controls were mainly matched for sex and age. Among the controls, 14 studies were autogenous (tissues from corresponding adjacent normal tissues) Toyooka et al, 2003;Wang et al, 2004;Choi et al, 2005;Dammann et al, 2005;Ito et al, 2005;Chen et al, 2006;Hsu et al, 2007;Kim et al, 2007;Yanagawa et al, 2007;Liu et al, 2008;Song et al, 2011), and 5 were heterogeneous (tissues from non-cancerous respiratory diseases) (Lin et …”

Section: Study Characteristicsmentioning

confidence: 99%

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Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Liu¹,

Tan²,

Guo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: RASSF1A has been reported to be a candidate tumor suppressor in non-small cell lung cancer (NSCLC). However, the association between RASSF1A promoter methylation and NSCLC remains unclear, particularly in regarding links to clinicopathologic features. Methods: Eligible studies were identified through searching PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure (CNKI) databases. Studies were pooled and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated. Funnel plots were also performed to evaluate publication bias. Keywords: RAS associations domain family protein 1A -non-small cell lung cancer -methylation -odds ratio

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Section: Subgroup Analysismentioning

confidence: 94%

Section: Associations Between Rassf1a Promoter Methylation and Nsclc:mentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Liu¹,

Tan²,

Guo³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Microtubule‐damaging agents enhance RASSF1A‐induced cell death in lung cancer cell lines

Whang¹,

Park²,

Jung³

et al. 2009

Cancer

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Objective To summarize research pertaining to work disability in lupus patients, discuss challenges patients face applying for federal disability assistance in the US, and make recommendations for clinical and health policy research. Methods We searched Medline for articles on work or disability in lupus patients and gathered information from the Social Security Administration and the National Organization of Social Security Claimants' Representatives. Results We found 12 publications with employment‐related data; 6 included analysis of predictors of work status. The prevalence of inability to work or cessation of work was 15–51% in these studies (3–15 years after diagnosis); 20–32% of patients received disability benefits. Lower education level, higher disease activity, higher disease damage, older age, and higher physical job strain were independent predictors of work disability or work cessation in at least 2 studies. Lupus patients may be less successful than patients with other diseases when applying for federal disability assistance, possibly because medical records may not accurately reflect functional limitations. In addition, symptoms contributing to work disability (e.g., fatigue, pain, neurocognitive dysfunction) may be difficult to assess and quantify. Conclusion Work disability in lupus patients is common. Additional research on risk factors for work disability in lupus patients and on strategies for reducing the impact of these factors on work‐related activities is needed. The development of better measures and rating scales for the symptoms responsible for work disability in lupus patients and studies of factors influencing the success of obtaining federal disability benefits would also be useful.

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Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer

Jin

Zhao

Cheng

et al. 2013

Cancer

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Endoglin (ENG) is a 180-kDa transmembrane glycoprotein that functions as a component of the transforming growth factor-β receptor complex. Recently, ENG promoter hypermethylation was reported in several human cancers. We examined ENG promoter hypermethylation using real-time quantitative methylation-specific PCR in 260 human esophageal tissues. ENG hypermethylation showed highly discriminative receiver-operator characteristic curve profiles, clearly distinguishing esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) from normal esophagus (N) (p<0.01). Interestingly, ENG normalized methylation values were significantly higher in ESCC than in N (p<0.01) or EAC (p<0.01). ENG hypermethylation frequency was 46.2% in ESCC and 11.9% in N, but increased early and sequentially during EAC-associated neoplastic progression, to 13.3% in Barrett’s metaplasia (BE), 25% in dysplastic BE (D), and 26.9% in frank EAC. ENG hypermethylation was significantly higher in N from ESCC patients (mean = 0.0186) than in N from EAC patients (mean = 0.0117; p < 0.05). Treatment of KYSE220 ESCC cells with the demethylating agent, 5-aza-2′-deoxycytidine, reversed ENG methylation and reactivated ENG mRNA expression. We conclude that promoter hypermethylation of ENG is a frequent, tissue-specific event in human ESCC and exhibits a field defect with promising biomarker potential for the early detection of ESCC. In addition, ENG hypermethylation occurs in a subset of human EAC, and early during BE-associated esophageal neoplastic progression.

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CpG island methylation and expression of tumour-associated genes in lung carcinoma

Cited by 141 publications

References 32 publications

Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Associations Between RASSF1A Promoter Methylation and NSCLC: A Meta-analysis of Published Data

Microtubule‐damaging agents enhance RASSF1A‐induced cell death in lung cancer cell lines

Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer

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