CpG Induces Th1 Response in Neonatal Mice but Does Not Suppress Anaphylactic IgG1 Response: Possible Role of Low TLR-9 Expression

Brito, Cyro Alves de; Fusaro, Ana Elisa; Victor, Jefferson Russo; Goldoni, Adriana Letícia; Rigato, Paula Ordonhez; Duarte, Alberto J. S.; Sato, Maria Notomi

doi:10.1016/j.clim.2007.03.403

Cited by 2 publications

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“…Our group has been investigating adoptive maternal-foetal immune interactions in the context of allergy regulation. [1][2][3][4][5][6][7][8][9][10] The potential of IgG antibodies as allergy regulators has been discussed for decades. In the early 80s, direct evidence that maternal IgG can suppress IgE production in offspring was obtained in a murine model of ovalbumin (OVA) immunization.…”

Section: Introductionmentioning

confidence: 99%

Low doses of IgG from atopic individuals can modulatein vitroIFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach

Sgnotto

Oliveira

Lira

et al. 2017

Human Vaccines & Immunotherapeutics

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The regulatory effect of allergic responses induced by IgG antibodies on human intra-thymic cells has not been reported in the literature. The aim of this study was to evaluate the possible differential effect of purified IgG from atopic and non-atopic individuals on human intra-thymic αβT cell cytokine production. Thymic tissues were obtained from 14 patients who were less than 7 d old. Additionally, blood samples were collected from atopic and non-atopic volunteers. Thymocytes and peripheral blood mononuclear cells were cultured with purified atopic or non-atopic IgG, and intracellular cytokine production was assessed. Purified IgG did not influence the frequency or viability of human intra-thymic αβT cells. Purified non-atopic IgG induced greater IFN-γ production by intra-thymic CD4+CD8+ T cells than did the mock treatment and atopic IgG. A similar effect of purified non-atopic IgG on TCD8 cells was observed compared with the mock treatment. Atopic IgG inhibited IFN-γ and TGF-β production by intra-thymic TCD4 cells. Treatment with intravenous immunoglobulin resulted in intermediate levels of IFN-γ and TGF-β in intra-thymic TCD4 cells compared with treatment with atopic and non-atopic IgG. Peripheral TCD4 cells from non-atopic individuals produced IFN-γ only in response to atopic IgG. This report describes novel evidence revealing that IgG from atopic individuals may influence intracellular IFN-γ production by intra-thymic αβT cells in a manner that may favor allergy development.

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Section: Introductionmentioning

confidence: 99%

Low doses of IgG from atopic individuals can modulatein vitroIFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach

Sgnotto

Oliveira

Lira

et al. 2017

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

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Immune Adjuvants in Early Life: Targeting the Innate Immune System to Overcome Impaired Adaptive Response

2009

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The neonatal phase is a transitory period characterized by an absence of memory cells, favoring a slow adaptive response prone to tolerance effects and the development of Th2-type responses. However, when appropriately stimulated, neonates may achieve an immune response comparable with adult counterparts. One strategy to stimulate the immunological response of neonates or children in early infancy has been to explore natural or synthetic ligands of cell receptors to stimulate innate immunity. The use of adjuvants for activating different cell receptors may be the key to enhancing neonatal adaptive immunity. This review highlights recent advances in the emerging field of molecular adjuvants of innate immune response and their implications for the development of immunotherapies, with particular focus on the neonatal period.

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CpG Induces Th1 Response in Neonatal Mice but Does Not Suppress Anaphylactic IgG1 Response: Possible Role of Low TLR-9 Expression

Cited by 2 publications

References 0 publications

Low doses of IgG from atopic individuals can modulatein vitroIFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach

Low doses of IgG from atopic individuals can modulatein vitroIFN-γ production by human intra-thymic TCD4 and TCD8 cells: An IVIg comparative approach

Immune Adjuvants in Early Life: Targeting the Innate Immune System to Overcome Impaired Adaptive Response

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