CPAP and behavioral therapies in patients with obstructive sleep apnea: Effects on daytime sleepiness, mood, and cognitive function

Sánchez, Ana María; Martínez, Pilar; Miró, Elena; Bardwell, Wayne A.; Buela-Casal, Gualberto

doi:10.1016/j.smrv.2008.07.002

Cited by 132 publications

(93 citation statements)

References 73 publications

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“…Most studies found improvement in attention and vigilance after CPAP treatment, while improvement in executive function was less reported [9]. Similar to these findings, improvement in attention domain with no change in executive, working memory and planning domain were also found in our poor and good compliant groups, both after one-night and three-month treatment.…”

Section: Discussionsupporting

confidence: 85%

“…Most of neurocognitive studies evaluate at least 4 weeks after CPAP treatment [9]. Orth et al report improvement of reaction time in 2 and 42 days of CPAP treatment on their study for good compliant patients [27].…”

Section: Discussionmentioning

confidence: 99%

“…However, the compliance of CPAP treatment in most sleep center is as low as 30-60 % [8]. The effects of CPAP treatment on the cognitive function are controversial with various results [2,4,[9][10][11]. Various CPAP compliances, different measurement tools and condition are factors confounding these results [9].…”

Section: Introductionmentioning

confidence: 99%

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Immediate and Long-term Neurocognitive Outcome in Patients with Obstructive Sleep Apnea Syndrome After Continuous Positive Airway Pressure Treatment

Lin

Chou

Kao

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Neurocognitive dysfunction is a major clinical consequence in patients with obstructive sleep apnea syndrome (OSAS). The effects of continuous positive airway pressure (CPAP) treatment, as the gold standard of treatment in OSAS, on this major complication are controversial. The duration and compliance of CPAP are thought to be important factors but evidence is lacking. This study is designed to evaluate the effects of immediate (one night), long-term (3 months) influence and the compliances of CPAP treatment on the neurocognitive function in OSAS patients. We enrolled newly diagnosed severe OSAS patients. Neurocognitive function test battery, CANTAB (Cambridge Neuropsychological Test Automated Battery), was performed before, one night and 3 months of CPAP treatment. Patients with CPAP compliance rate C 70 % and \ 50 % were grouped into good and poor adherence subjects, respectively. Fourteen patients were enrolled in final analyses. Six of them were in poor compliant group. Improvements in attention domain were found in all subjects after one-night treatment and maintained till threemonth follow-up. Additional improvements in some attention performances and visual memory performances were gained only after three-month treatment. Significant changes of decision-making and response control function were found between good and poor compliance groups after three-month treatment. CPAP can improve some neurocognitive function at the very first day used. Longer treatment of CPAP can additionally improve some other neurocognitive functions. Compliance of CPAP has influence on the recovery of neurocognitive functions in patients with severe OSAS.Electronic supplementary material The online version of this article

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Immediate and Long-term Neurocognitive Outcome in Patients with Obstructive Sleep Apnea Syndrome After Continuous Positive Airway Pressure Treatment

Lin

Chou

Kao

et al. 2014

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…There is considerable evidence that CPAP use reduces cardiovascular morbidity, mortality, and road traffic accidents traffic consequences in patients with OSA. [18][19][20][21][22] Despite the severity of the consequences of OHS, CPAP may improve the symptoms and selected clinical variables of the disease [23][24][25][26] ; however, data showing positive effects on prospective cardiovascular or other variables are limited and prospective studies are awaited.…”

mentioning

confidence: 99%

Morbidity prior to a Diagnosis of Sleep-Disordered Breathing: A Controlled National Study

Jennum

Ibsen²,

Kjellberg³

2013

Journal of Clinical Sleep Medicine

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“…Excessive daytime sleepiness (EDS) is the most common symptom observed during wakefulness in these patients, which may have induced the initial studies to consider cognitive impairment as being entirely secondary to EDS. More recent investigations, however, have shown that neuronal damage determined by intermittent hypoxia may affect performance on neuropsychological tests 11 . This theory has been recently supported by a study using functional neuroimaging associated with neuropsychological testing in patients with OSA 12 .…”

mentioning

confidence: 99%

Impact of obstructive sleep apnea on cognitive performance

Bawden

Oliveira²,

Caramelli

2011

Arq. Neuro-Psiquiatr.

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Objective: To evaluate the impact of obstructive sleep apnea (OSA) on cognition. Method: We compared the performance of 17 patients with polysomnographic diagnosis of OSA in brief cognitive tests to that of 20 healthy controls, matched for age and education. The testing battery included the Mini-Mental State Examination (MMSE), Brief Cognitive Screening Battery (BCSB), Digit-Symbol (DS) and Phonemic Verbal Fluency (FAS). Anthropometric measures and scores from the Epworth Sleepiness Scale were also recorded. Results: OSA patients performed significantly worse than controls in the MMSE, in memory items from the BCSB, in DS and also in FAS. OSA patients also exhibited higher body mass index, increased neck circumference and higher scores in Epworth Sleepiness Scale than controls. Conclusion: OSA significantly impairs cognitive performance, especially within the domains of attention, memory and executive functioning. These deficits may be detected by brief and easy-to-administer cognitive tests. Obstructive sleep apnea (OSA) is a disorder associated with episodic sleep disruptions in airway patency, followed by reduction of oxygen saturation and arousals throughout the night. In result of the chronic deprivation of sleep which it determines, OSA can lead to impairment of productivity at work, traffic accidents and also to endocrine and cardiovascular diseases [1][2][3][4][5] .The prevalence of OSA is estimated to range from 2% to 4% of the population aged 30 to 60 years, according to the first major US population-based study con-

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CPAP and behavioral therapies in patients with obstructive sleep apnea: Effects on daytime sleepiness, mood, and cognitive function

Cited by 132 publications

References 73 publications

Immediate and Long-term Neurocognitive Outcome in Patients with Obstructive Sleep Apnea Syndrome After Continuous Positive Airway Pressure Treatment

Immediate and Long-term Neurocognitive Outcome in Patients with Obstructive Sleep Apnea Syndrome After Continuous Positive Airway Pressure Treatment

Morbidity prior to a Diagnosis of Sleep-Disordered Breathing: A Controlled National Study

Impact of obstructive sleep apnea on cognitive performance

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