Abstract:BackgroundCardiotoxicity is a known risk of anthracycline treatment. The probability of developing impaired myocardial function is estimated to be 1–2% at a total cumulative dose of 300 mg/m2
of doxorubicin, whereas the risk dramatically increases (5–20%) when the doxorubicin cumulative dose (DCD) exceeds 450–500 mg/m2
. Although cardiotoxicity may also occur at lower doses, depending on age and pre-existing heart disease, this is considered to be the threshold above which the use of doxorubicin is contraindi… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.