Coxsackievirus and adenovirus receptor (CAR)-positive immature osteoblasts as targets of adenovirus-mediated gene transfer for fracture healing

Expression of coxsackievirus and adenovirus receptor in human lung cancer: Possible clinical significance

“…This provides a physiological explanation for the downregulation of CAR observed in malignant glioma cells [26] . Downregulation of CAR has similarly been observed in other tumor types, including ovarian cancer [27,28] , melanoma [29] , head and neck cancer [27,[29][30][31][32] , malignant glioma [21] , musculoskeletal tumors [33] , immature osteoblasts [34] , human rhabdomyosarcoma [35] and bladder cancer [5,36] . Similarly, when compared with normal prostate, CAR expression decreased in prostate carcinoma specimens of all Gleason scores [37] .…”

High-Level Expression of the Coxsackievirus and Adenovirus Receptor Messenger RNA in Osteosarcoma, Ewing’s Sarcoma, and Benign Neurogenic Tumors among Musculoskeletal Tumors

“…Our previous study (1) showed that a high level of CAR expression had been observed in most osteosarcoma cell lines. Ito et al (27) reported that immature osteoblasts in a rib fracture model had expressed a high level of CAR. These results implied that CAR mRNA is expressed in osteogenic cells.…”

Osteogenic gene regulation and relative acceleration of healing by adenoviral‐mediated transfer of human BMP‐2 or ‐6 in equine osteotomy and ostectomy models

“…15 In addition, delayed injection may coincide with peak expression of adenovirus receptor on immature osteoblasts and support more efficient adenoviral gene deliver. 23 Injection of Ad-BMP-2 at the time of surgery can, however, effectively enhance bone healing in rodent models, 3,4 even if the outcome is less than optimal. It has also been noted that Ad-BMP-6 vector delivered into an ulna osteotomy in rabbits resulted in undesirable migration of the vector and heterotopic bone formation.…”