Coxsackie Viral Infections

Lerner, A. Martin; Finland, Maxwell

doi:10.1001/archinte.1961.03620090001001

Cited by 13 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,3 Enterovirus is the leading causative virus, especially Coxsackie virus A7, A9, and A23 and Coxsackie virus B serotypes, which are frequently implicated in cases of meningoencephalitis, is often associated with transverse myelitis. 4,5 The disease is rarely recurrent and is an infrequent harbinger of multiple sclerosis. The onset of symptoms is rarely rapid, and they usually evolve over one to three weeks, smoothly or stepwise, with severe back pain followed by paralysis.…”

Section: Introductionmentioning

confidence: 99%

Acute transverse myelitis due to Coxsackie virus

Starakis

Marangos

Giali

et al. 2005

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Acute transverse myelitis due to Coxsackie virus

Starakis

Marangos

Giali

et al. 2005

Journal of Clinical Neuroscience

View full text Add to dashboard Cite

“…Infection in the newborn mouse is lethal only if initiated during the first 10 days of life with Coxsackie A viruses, or during the first 48 hours after birth with Coxsackie B viruses (2). Human adults, on the other hand, are frequently infected with Coxsackie viruses although the resulting illnesses are usually less severe than in infants and children (3)(4)(5). The increasing numbers of reports of the great variety of manifestations of Coxsackie virus infections in humans would seem to indicate that they have much in common with those described in suckling mice (5).…”

mentioning

confidence: 99%

“…Human adults, on the other hand, are frequently infected with Coxsackie viruses although the resulting illnesses are usually less severe than in infants and children (3)(4)(5). The increasing numbers of reports of the great variety of manifestations of Coxsackie virus infections in humans would seem to indicate that they have much in common with those described in suckling mice (5). However, whereas infections with Coxsackie B viruses in adult mice have been described, very little has been reported about the effects of Coxsackie A viruses in the adult mouse.…”

mentioning

confidence: 99%

Age and Susceptibility of Mice to Coxsackie a Viruses

Lerner

Levin

Finland

1962

The Journal of Experimental Medicine

Self Cite

View full text Add to dashboard Cite

Mice varying in age from 1 day to 8 months were inoculated intraperitoneally with Coxsackie A virus, type 9 and studies were made of the quantity of virus in striated muscle and myocardium, the presence of neutralizing antibody in the serum, and the pathological changes in the tissues. The hind limbs of young (1- to 20-day-old) mice yielded high titers of virus and showed diffuse myositis, whereas only low yields of virus and focal myositis were obtained in older mice. In the 20-day-old mice the skeletal lesions were not accompanied by manifest symptoms and histologically showed evidence of regeneration progressing from the 3rd to the 11th day after inoculation. Older mice showed no symptoms and only focal myositis and low yields of virus were found in their hind limbs. Coxsackie A9 virus replicated to relatively low titers in the hearts of young (1- to 40-day-old) mice without producing any demonstrable lesions whereas frank myocarditis with high yields of virus were demonstrated in mice infected at 8 months of age. The data suggest that at least for the 2 strains used, the adult mouse should be considered susceptible to subclinical infection with Coxsackie A9 virus. Neither subclinical infection, nor antibody formation was demonstrable in young adult mice inoculated with a strain of Coxsackie A4 virus.

show abstract

Hepatitis Associated with a Coxsackie B5 Virus Infection During Late Pregnancy

O'Shaughnessey¹

1962

JAMA

View full text Add to dashboard Cite

A 21-year-old white female was admitted to Charity Hospital of Louisiana on Oct. 23, 1959, with a diagnosis of "meningitis." The patient was 7 months pregnant (gravida 6, para 5). She had been in good health until 7 days prior to admission, when she developed a generalized headache, malaise, and a low-grade fever. Her physician felt that she had "flu" and treated her with tetracycline, 250 mg. every 6 hours. Two days later she developed projectile vomiting without nausea. At this time she was admitted to a private hospital and treated with intravenous fluids and "shots." Three days before admission, her speech became slurred and indistinct, and she exhibited confusion, restlessness, and athetoid movements of the right hand. She also developed marked injection of the eonjunctivae associated with inability to close her eyelids. Laboratory examination at that time disclosed: hematocrit, 37 mm.; white blood cells, 12,650 per cubic millimeter; neutrophils, 67 per cent; basophils, 1 per cent; monocytes, 2 per cent; and lymphocytes, 30 per cent. A spinal tap revealed an opening pressure of 180 mm. of water. The fluid contained 211 white blood cells per cubic millimeter with a differen¬ tial count of 60 per cent lymphocytes and 40 per cent neutrophils. The cerebrospinal fluid protein was 90 mg. per cent.The patient was transferred to the Contagious Disease Unit of Charity Hospital, where it was learned that she lived in rural Louisiana, near a swamp and bayou. Rats had been seen in the vicinity. There was an outdoor privy as well as an indoor toilet. Drinking water was obtained from the purified city system. There had been no contacts with individuals known to be ill, and her past medical history was essentially negative.Physical examination revealed a well-developed, wellnourished, pregnant, white female who was acutely ill, restless, irritable, and mentally dull. Blood pressure level was 110/70 mm. Hg; pulse, 96 beats per minute; respira¬ tions, 24 per minute. The oral temperature was 98°F.(36.7°C. ). Both eyelids were held partially open and could not be closed voluntarily. There was marked injection of the conjunctivae. The eyes tended to remain in an upward gaze, but the patient could voluntarily move them to a central position. However, attempts to deviate the eyes laterally resulted in coarse, jerking, nystagmoid movements. The pupils were equal and reacted to light. The fundi could not be examined adequately due to the patient's inability to cooperate. There was moderate pharyngeal injection without exúdate. Slight nuchal rigidity was pres¬ ent. The speech was slurred and indistinct. The liver and spleen were not palpable, but the uterus was enlarged to 2M¡ finger breadths above the umbilicus. Fetal heart tones at 140 beats per minute were audible in the left lower quadrant. Neurological abnormalities included bilateral Babinski responses and absence of the biceps, triceps, supinator, and abdominal reflexes. The ankle jerks were present, and knee jerks were hyperactive bilaterally. There was no impairment of sens...

show abstract

Coxsackie Viral Infections

Cited by 13 publications

References 27 publications

Acute transverse myelitis due to Coxsackie virus

Acute transverse myelitis due to Coxsackie virus

Age and Susceptibility of Mice to Coxsackie a Viruses

Hepatitis Associated with a Coxsackie B5 Virus Infection During Late Pregnancy

Contact Info

Product

Resources

About