Coxsackie B2 virus fatal meningoencephalitis in a student

Carvalho, Eduardo S.; Abramczyk, Marcelo Luiz; Brezolin, Antonio U.; Souza, Denise F. C.; Inocêncio, Lilian A.; Paiva, Terezinha Maria de

doi:10.2223/jped.63

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Enteroviral meningoencephalitis is relatively well documented around the world, although most studies have focused on ‘epidemic’ EV-types rather than ‘sporadic’ ones, such as CVB2. To date, only one case of CVB2 causing meningoencephalitis has been reported in Brazil, based on serological evidence 5 . Thus, information regarding the molecular epidemiology of this agent is limited.…”

Section: Introductionmentioning

confidence: 99%

Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018

Sousa

Machado

Burlandy

et al. 2021

Rev. Soc. Bras. Med. Trop.

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Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections.

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Section: Introductionmentioning

confidence: 99%

Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018

Sousa

Machado

Burlandy

et al. 2021

Rev. Soc. Bras. Med. Trop.

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Laboratory Aids for Diagnosis of Neonatal Sepsis

Weinberg¹,

D’Angio²

2011

Infectious Diseases of the Fetus and Newborn

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Enteroviral meningitis at a pediatric hospital in Dakar (Senegal)

Lamine Dia,

et al. 2020

JPNC

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Introduction: Enteroviral meningitis is the main cause of meningitis for all causes combined. They are frequent and most often benign, but underdiagnosed due to the limited technical platforms of laboratories. This is why we deemed it important to carry out this study aimed at determination of the role of these viruses in aseptic meningitis at the pediatric hospital of Diamniadio in Dakar. Materials and methods: This was a prospective study covering the period from the 1st of January to the 31st of August 2017 involving 30 patients from the children’s hospital of Diamniadio. The cytochemical tests and the assessments of soluble antigens in the CSFs were carried out at the laboratory of the hospital of Diamniadio. The virological tests were carried out at the Pasteur Institute of Dakar. Results: All up, 30 aseptic CSFs were received by the laboratory during the study period. The patients were aged from 0 to 15 years. The analysis of the CSFs found an average protein concentration level of 1.15g/L and an average glucose level of 0.52g/L. No microbial organisms were detected by conventional bacteriological analyses. The virological analyses, on the other hand, allowed 9 Enteroviruses and 1 cytomegalovirus (CMV) to be found in the CSFs. Conclusion: Enteroviruses constitute a significant part of the etiologies of viral meningitis in Senegal. Larger scale studies are needed, however, to obtain a more accurate indication of the viral causes of meningitis in Senegal.

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Coxsackie B2 virus fatal meningoencephalitis in a student

Cited by 3 publications

References 15 publications

Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018

Detection and characterization of a coxsackievirus B2 strain associated with acute meningoencephalitis, Brazil, 2018

Laboratory Aids for Diagnosis of Neonatal Sepsis

Enteroviral meningitis at a pediatric hospital in Dakar (Senegal)

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