COX-2 Inhibitors

Houston, Avril Melissa; Teach, Stephen J.

doi:10.1097/01.pec.0000133618.36861.73

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…Many patients demonstrate side effects of nonsteroidal anti-inflammatory drugs [7–9]. At the same time, a limited number of papers point to the effectiveness of deep tissue massage.…”

Section: Introductionmentioning

confidence: 99%

Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

Majchrzycki

Kocur

Kotwicki

2014

The Scientific World Journal

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Objective. To investigate whether chronic low back pain therapy with deep tissue massage (DTM) gives similar results to combined therapy consisting of DTM and non-steroid anti-inflammatory drugs (NSAID). Design. Prospective controlled randomized single blinded trial. Settings. Ambulatory care of rehabilitation. Participants. 59 patients, age 51.8 ± 9.0 years, with chronic low back pain. Interventions. 2 weeks of DTM in the treatment group (TG) versus 2 weeks of DTM combined with NSAID in the control group (CG). Main Outcome Measures. Visual analogue scale, Oswestry disability index (ODI), and Roland-Morris questionnaire (RM). Results. In both the TG and the CG, a significant pain reduction and function improvement were observed. VAS decreased from 58.3 ± 18.2 to 42.2 ± 21.1 (TG) and from 51.8 ± 18.8 to 30.6 ± 21.9 (CG). RM value decreased from 9.8 ± 5.1 to 6.4 ± 4.4 (TG), and from 9.3 ± 5.5 to 6.1 ± 4.6 (CG). ODI value decreased from 29.2 ± 17.3 to 21.4 ± 15.1 (TG) and from 21.4 ± 9.4 to 16.6 ± 9.4 (CG). All pre-post-treatment differences were significant; however, there was no significant difference between the TG and the CG. Conclusion. DTM had a positive effect on reducing pain in patients with chronic low back pain. Concurrent use of DTM and NSAID contributed to low back pain reduction in a similar degree that the DTM did.

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“…Many patients demonstrate side effects of nonsteroidal anti-inflammatory drugs [7–9]. At the same time, a limited number of papers point to the effectiveness of deep tissue massage.…”

Section: Introductionmentioning

confidence: 99%

Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

Majchrzycki

Kocur

Kotwicki

2014

The Scientific World Journal

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“…There are two isoforms of cyclooxygenases: cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) [2]. COX-1 is expressed constitutively in most tissues and responsible for various physiological functions [3].…”

Section: Introductionmentioning

confidence: 99%

Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth

et al. 2014

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Activating enhancer-binding protein-2α (AP-2α) regulates the expression of many cancer-related genes. Here, we demonstrated a novel mechanism by which AP-2α up-regulated cyclooxygenase-2 (COX-2) expression to promote the growth of nasopharyngeal carcinomas (NPCs). High expression of AP-2α in NPC cell lines and tumor tissues from NPC patients was detected and significantly correlated with COX-2 expression. Overexpression of AP-2α and COX-2 in tumor tissues was associated with advanced tumor stage, clinical progression, and short survival of patients with NPCs. Knockdown of AP-2α by siRNA markedly inhibited COX-2 expression and PGE2 production in NPC cells. Exogenous expression of AP-2α up-regulated the COX-2 and PGE2. Knockdown of AP-2α also significantly suppressed cell proliferation in NPC cells in vitro and tumor growth in a NPC xenograft mouse model. Moreover, we found that p300 played an important role in the AP-2α/COX-2 pathway. AP-2α could co-localize and interact with p300 in NPC cells. Overexpression of the p300, but not its histone acetyltransferase (HAT) domain deletion mutant, promoted the acetylation of AP-2α and its binding on the COX-2 promoter, thereby up-regulated COX-2 expression. Our results indicate that AP-2α activates COX-2 expression to promote NPC growth and suggest that the AP-2α/COX-2 signaling is a potential therapeutic target for NPC treatment.

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“…4. Nonsteroidal anti-inflammatory drugs (NSAIDs) [46][47][48][49] Sodium salicylate was the first NSAID discovered in 1763 [45]. NSAIDs have been especially used to treat pain and inflammation from medical conditions such as arthritis, menstrual cramps and other types of short-term pain.…”

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confidence: 99%

A Randomized Controlled Trial on the Effectiveness of Court-Type Traditional Thai Massage Versus Topical Diclofenac to Treat Frozen Shoulder

Tankitjanon

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This study aims to evaluate the effectiveness of the court-type traditional Thai massage (CTTM) in treating patients suffering from frozen shoulder in comparison with topical diclofenac (TD). A randomized controlled trial was conducted at the Thai Traditional Medical Service Center, Sukhothai Thammatirat University, Nonthaburi province. The participants of idiopathic frozen shoulder were diagnosed by the orthopedic doctor. Sixty female patients aged were randomly assigned to receive CTTM (treatment group, n=30) and TD (control group, n=30). CTTM was performed for 12 sessions during a 1?6 week period, and followed up at week 8th, 10th. TD was administered 5 g three times a day for 6 weeks, and followed up at week 8th, 10th. The outcomes of this research were assessed by shoulder range of motion (SROM), pain intensity (by VAS), Disabilities of the Arm, Shoulder and Hand (DASH), shoulder function assessment (by VAS) and quality of life (QoL). Descriptive statistics was used as percentage, mean and standard deviation. Inferential statistics was used by repeated ANOVA, Friedman test, paired t-test and student t-test. The results found that the comparison within the same group in both CTTM and TD groups showed the significant improvement of SROM (P<0.05) but the average values of SROM of CTTM group at week2 nd week4th and week6 th were significantly better than those of TD group (p<0.05). Both CTTM and TD groups showed the significant relief pain intensity at week2 nd week4th and week6 th (P<0.05), but VAS scores of CTTM group were significantly better than those of TD group. DASH and VAS (shoulder function assessment) score significantly decreased after treatment (p < 0.0001). In addition, the scores between CTTM and TD groups after treatment were not significantly different. The overall picture of quality scores indicated that both CTTM and TD showed significant improvement of QoL within the same group (P<0.05). In addition, the scores of QoL between CTTM and TD groups after treatment showed that CTTM group was significantly better than TD group. Both CTTM and TD were capable to heal frozen shoulder and demonstrated a positive effect but CTTM could cure frozen shoulder better than TD. The side effects of CTTM were not found.

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COX-2 Inhibitors

Cited by 9 publications

References 41 publications

Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

Deep Tissue Massage and Nonsteroidal Anti-Inflammatory Drugs for Low Back Pain: A Prospective Randomized Trial

Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth

A Randomized Controlled Trial on the Effectiveness of Court-Type Traditional Thai Massage Versus Topical Diclofenac to Treat Frozen Shoulder

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