COX-2 CA-Haplotype Is a Risk Factor for the Development of Esophageal Adenocarcinoma

Moons, Leon M.G.; Kuipers, Ernst J.; Rygiel, Agnieszka Magdalena; Groothuismink, A.; Geldof, Han; Bode, W. A.; Krishnadath, Kausilia K.; Bergman, Jacques J.G.H.M.; Vliet, Arnoud H. M. van; Siersema, Peter D.; Kusters, Johannes G.

doi:10.1111/j.1572-0241.2007.01373.x

Cited by 38 publications

(31 citation statements)

References 41 publications

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“…In addition, the COX-2 polymorphism data in our patients are very similar to the recently reported COX-2 -765 and -1195 genotype distributions in Dutch esophageal adenocarcinoma patients by Moons et al [17] , except for the -1195 GG genotype, which was present in 8.0% of our patients vs only 2.0% in the patients in the study by Moons et al [17] .…”

Section: Discussionsupporting

confidence: 72%

“…Analyzing the COX-2 haplotypes showed that the GG/GG haplotype was present more often in the esophageal carcinoma group, which again is not in accordance with the results of Zhang et al [12] and Moons et al [17] , who both found that the CA containing haplotypes carried the highest risk. Since the results of Zhang et al [12] and Moons et al [17] on different types of tumors (squamous cell carcinoma vs adenocarcinoma, respectively) are very similar, and more or less contradict our results, it was of interest to compare the haplotype distribution between our patients with squamous cell carcinoma vs adenocarcinoma.…”

Section: Discussioncontrasting

confidence: 44%

“…The distribution of the -765 genotypes in the control group was not found to be significantly different when compared to the esophageal carcinoma group, whereas Moons et al [17] reported a significantly different -765 CC genotype distribution between a Dutch esophageal carcinoma group (n = 140) and a Barrett's esophagus (n = 255) or reflux esophagitis (n = 240) patient group. It should be noted, however, that the number of -765 CC genotype individuals in these patient groups was very low, being seven, four and zero individuals, respectively [17] .…”

Section: Discussionmentioning

confidence: 89%

“…Since the results of Zhang et al [12] and Moons et al [17] on different types of tumors (squamous cell carcinoma vs adenocarcinoma, respectively) are very similar, and more or less contradict our results, it was of interest to compare the haplotype distribution between our patients with squamous cell carcinoma vs adenocarcinoma. However, no significant differences were found.…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted, however, that the number of -765 CC genotype individuals in these patient groups was very low, being seven, four and zero individuals, respectively [17] . Two main reasons for the difference in results between the two Dutch studies are as follows: firstly, our study was performed on a larger patient population than the study by Moons et al [17] (252 vs 140 patients), and secondly in our study, similar to the study by Zhang et al [12] , a comparison between patients with esophageal cancer and healthy controls was made, in contrast to the study by Moons et al [17] where patients with Barrett's esophagus or reflux esophagitis, both of which are at risk for esophagus carcinoma, were used for comparison.…”

Section: Discussionmentioning

confidence: 99%

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Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

Kristinsson¹,

Westerveld²,

Morsche³

et al. 2009

WJG

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AIM:To determine whether -1195 A →G and/or -765 G →C polymorphisms in Cyclooxygenase-2 (COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. RESULTS: T h e d i s t r i b u t i o n o f t h e -

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Section: Discussionsupporting

confidence: 72%

Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

Kristinsson¹,

Westerveld²,

Morsche³

et al. 2009

WJG

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Molecular biology of Barrett's esophagus and esophageal adenocarcinoma

Noorani

Fitzgerald

2015

Esophageal Cancer and Barrett's Esophagus

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Cyclooxygenase‐2 gene polymorphisms reduce the risk of oral premalignant lesions

Pu¹,

Lippman²,

Yang³

et al. 2009

Cancer

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BACKGROUND: Oral premalignant lesions (OPLs) have the potential to transform into malignant oral cancers. Overexpression of the cyclooxygenase‐2 gene (COX‐2) is observed frequently in OPLs and oral cancers, suggesting that this gene may play an important role in the progression of oral cancer. Single‐nucleotide polymorphisms of COX‐2 have been associated with the risk of multiple cancers; however, to date, their effects on OPL susceptibility have not been evaluated sufficiently. METHODS: The authors conducted a case‐control study that included 147 patients with OPL and a group of 147 healthy, matched controls. The effects of 3 potentially functional COX‐2 polymorphisms on the risk of OPL were evaluated: the −765 G→C polymorphism (rs20417), the exon 10 +837 T→C polymorphism (rs5275), and the exon 10 −90 C→T polymorphism (rs689470). RESULTS: The variant‐containing genotypes of COX‐2 exon 10 +837T→C variant were associated with a significantly reduced risk of OPL (odds ratio [OR], 0.48; 95% confidence interval [95% CI], 0.28‐0.80). This protective effect also was significant in men, younger individuals, ever smokers, and ever drinkers. Consistently, a common halotype WMW (in the following order: −765G→C, exon 10 +837T→C, and exon 10 −90C→T; w, widetype; M, variable allele) and a common diplotype (WWW/WMW) that contained the variant allele of exon 10 +837T→C, both were associated with a reduced risk of OPL (WMW: OR, 0.55; 95% CI, 0.33‐0.93; WWW/WMW: OR, 0.44; 95% CI, 0.22‐0.89). In addition, using never smokers with the variant‐containing genotypes as the reference group, interaction effects were observed between specific COX‐2 variants and tobacco smoking in the modulation of OPL risk. CONCLUSIONS: Overall, the current results provided the first epidemiologic evidence indicating that potentially functional polymorphisms of the COX‐2 gene may have an impact on individual susceptibility to OPLs. Cancer 2009. © 2009 American Cancer Society.

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COX-2 CA-Haplotype Is a Risk Factor for the Development of Esophageal Adenocarcinoma

Abstract: The COX-2 CA-haplotype is more frequently observed in patients with EAC than in patients with BE and reflux esophagitis. These data suggest a direct link between COX-2 activity and neoplastic progression in patients with BE and reflux esophagitis.

Cited by 38 publications

References 41 publications

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma

Molecular biology of Barrett's esophagus and esophageal adenocarcinoma

Cyclooxygenase‐2 gene polymorphisms reduce the risk of oral premalignant lesions

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