COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells

Jung, In Duk; Jeong, Yoong Ki; Lee, Chang Min; Noh, Kyung Tae; Jeong, Soo Kyung; Chun, Sung Hak; Choi, Oksoon Hong; Park, Won Sun; Han, Jin; Shin, Yong Kyoo; Kim, Han Wool; Yun, Cheol Heui; Park, Yeong Min

doi:10.1016/j.intimp.2010.04.006

Cited by 44 publications

(38 citation statements)

References 42 publications

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“…Finally, in an in vitro and in vivo investigation, curcumin delivered to mice significantly attenuated LPS-induced increases in IDO expression in bone marrow-derived dendritic cells (Jung et al, 2010).…”

Section: Effects Of Curcumin On Immune Pathways <<mentioning

confidence: 91%

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

2012

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Curcumin is the principal curcuminoid of the popular Indian spice turmeric and has attracted increasing attention for the treatment of a range of conditions. Research into its potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. Research completed to date on the multiple effects of curcumin is reviewed in this paper, with a specific emphasis on the biological systems that are compromised in depression. The antidepressant effects of curcumin in animal models of depression are summarised, and its influence on neurotransmitters such as serotonin and dopamine is detailed. The effects of curcumin in moderating hypothalamus-pituitary-adrenal (HPA) disturbances, lowering inflammation, and protecting against oxidative stress, mitochondrial damage, neuroprogression and intestinal hyperpermeability, all of which are compromised in major depressive disorder, are also summarised. With increasing interest in natural treatments for depression, and efforts to enhance current treatment outcomes, curcumin is presented as a promising novel, adjunctive or stand-alone natural antidepressant.

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Section: Effects Of Curcumin On Immune Pathways <<mentioning

confidence: 91%

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

2012

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“…2F). Although PGE 2 was reported to promote immune tolerance through the enhancement of downstream IDO expression and activity (40)(41)(42), this redundancy suggests that MSC-secreted PGE 2 promotes the ontogeny of T R 1-like cells either directly or through IDO. However, in this study, the role of IDO in concerted immunomodulation of MSCs was investigated only by adding an IDO inhibitor in allogeneic MLR in vitro.…”

Section: Mscs Convert Cd4 + Cells Into Immunosuppressive T R 1-like Cmentioning

confidence: 99%

Prostaglandin E2 Potentiates Mesenchymal Stem Cell–Induced IL-10+IFN-γ+CD4+ Regulatory T Cells To Control Transplant Arteriosclerosis

Hsu

Lin

Chiang

et al. 2013

The Journal of Immunology

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Mesenchymal stem cells (MSCs) are known for their immunomodulatory functions. We previously demonstrated that bone marrow–derived MSCs effectively control transplant arteriosclerosis (TA) by enhancing IL-10+ and IFN-γ+ cells. The objective of this study is to elucidate the mechanism by which MSCs induce IL-10+IFN-γ+CD4+ regulatory T type 1 (TR1)–like cells. In an MLR system using porcine PBMCs, MSC-induced IL-10+IFN-γ+CD4+ cells, which confer resistance to allogeneic proliferation in an IL-10–dependent manner, resemble TR1-like cells. Both cyclooxygenase-derived PGE2 and IDO help to induce TR1-like cells by MSCs. MSCs constitutively secrete PGE2, which is augmented in allogeneic reactions. However, TR1-like cells were deficient in PGE2 and 4-fold less potent than were MSCs in suppressing MLR. PGE2 mimetic supplements can enhance the immunosuppressive potency of TR1-like cells. In a porcine model of allogeneic femoral arterial transplantation, MSC-induced TR1-like cells combined with PGE2, but not either alone, significantly reduced TA at the end of 6 wk (percentage of luminal area stenosis: TR1-like cells + PGE2: 11 ± 10%; PGE2 alone: 93 ± 8.7%; TR1-like cells alone: 88 ± 2.4% versus untreated 94 ± 0.9%, p < 0.001). These findings indicate that PGE2 helps MSC-induced IL-10+IFN-γ+CD4+ TR1-like cells inhibit TA. PGE2 combined with MSC-induced TR1-like cells represents a new approach for achieving immune tolerance.

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“…The enhanced prostaglandin E2 level by curcumin was attributed to the suppression of LPS-induced IDO production in this study. The curcumin or prostaglandin E2 treated DCs showed reduced proliferation of OVAspecific CD8 + T cells that was induced by LPS [36]. Although intravenous LPS (3 μg) injection reduces the splenic blood flow by 31% and reduces the access of Ag to the mouse spleen [37], a high dose of LPS (1.5 mg/kg body weight, i.p.)…”

Section: Immunoinhibitory Action Of Curcumin On Dendritic Cells (Dcs)mentioning

confidence: 99%

Immunomodulatory and therapeutic activity of curcumin

Srivastava

Singh²,

Dubey

et al. 2011

International Immunopharmacology

190

108

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COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells

Cited by 44 publications

References 42 publications

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Prostaglandin E2 Potentiates Mesenchymal Stem Cell–Induced IL-10+IFN-γ+CD4+ Regulatory T Cells To Control Transplant Arteriosclerosis

Immunomodulatory and therapeutic activity of curcumin

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