Cowries derived aragonite as raw biomaterials for bone regenerative medicine

Akilal, N.; Lemaire, Flora; Bercu, Nicolas Bogdan; Sayen, Stéphanie; Gangloff, Sophie C.; Khelfaoui, Youcef; Rammal, Hassan; Kerdjoudj, Halima

doi:10.1016/j.msec.2018.10.039

Cited by 17 publications

(10 citation statements)

References 18 publications

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“…Dessa forma, a fim de potencializar os efeitos das ondas ultrassônicas, sugere-se uma possível associação desse recurso terapêutico a um arcabouço tridimensional, que servirá de maior suporte estrutural e mecânico, potencializará o crescimento celular e induzirá a diferenciação celular. 16,30 Conclusão O ultrassom terapêutico estimulou o reparo do defeito ósseo crítico, e o tempo mais longo de exposição promoveu maior estímulo osteogênico.…”

Section: Discussionunclassified

Análise comparativa do efeito de dois protocolos de ultrassom terapêutico para regeneração de defeito ósseo crítico

Daltro

Barreto

Almeida

et al. 2020

Rev Bras Ortop (Sao Paulo)

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Resumo Objetivo Comparar o efeito de dois protocolos de ultrassom terapêutico com diferentes tempos de exposição para regeneração de defeito ósseo crítico. Métodos Foram utilizados 45 ratos, machos, distribuídos em três grupos: grupo ultrassom terapêutico 5 minutos (GUS 5); grupo ultrassom terapêutico 10 minutos (GUS 10); e grupo controle (GC). Em todos os grupos, confeccionou-se um defeito ósseo crítico, com 8,5 mm de diâmetro, na região da calvária. O protocolo foi iniciado no 1° dia do pós-operatório, no GUS 5 e no GUS 10, com ultrassom terapêutico na frequência de 1,0 MHz, modo pulsado, 5 vezes por semana, nos períodos de 15, 30, e 60 dias. Resultados Dentre os grupos experimentais, houve maior neoformação de matriz osteoide no GUS 10, seguido do GUS 5 quando comparados ao GC, no qual a neoformação foi restrita à região de borda. O uso do ultrassom promoveu aumento na espessura da matriz conjuntiva, proliferação de capilares, alinhamento das fibras colágenas, redução do edema e do processo inflamatório, tendo sido mais significativo no tempo de 10 minutos. Conclusão O ultrassom terapêutico estimulou o reparo do defeito ósseo crítico, e o maior tempo de exposição promoveu maior estímulo osteogênico.

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Section: Discussionunclassified

Análise comparativa do efeito de dois protocolos de ultrassom terapêutico para regeneração de defeito ósseo crítico

Daltro

Barreto

Almeida

et al. 2020

Rev Bras Ortop (Sao Paulo)

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“…In fact, the unique feature of this novel scaffold is its ability to restore the subchondral bone, as documented by extensive in vitro studies, which showed not only its osteoinductive and osteoconductive capabilities but also unique osteotransductive properties, that is, the formation of bone through the direct deposition of bone trabeculae on the scaffold material. 1,15,20,34,43 The chondrogenic potential of the articular phase of the scaffold has been studied in another ex vivo trial, 5 and these findings were also confirmed in a goat model in which the scaffold was able to restore the entire osteochondral unit even in extremely large defects. 26-28…”

mentioning

confidence: 87%

Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study

et al. 2021

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Background: Osteoarthritis (OA) is considered a contraindication to most cartilage repair techniques. Several regenerative approaches have been attempted with the aim of delaying or preventing joint replacement, with controversial results. Currently, there is a paucity of data on the use of single-step techniques, such as cell-free biomimetic scaffolds, for the treatment of joint surface lesions (JSLs) in OA knees. Purpose: To present the 2-year follow-up clinical and radiological outcomes after implantation of a novel, cell-free aragonite-based scaffold for the treatment of JSLs in patients with mild to moderate knee OA in a multicenter prospective study. Study Design: Case series; Level of evidence, 4. Methods: A total of 86 patients, 60 male and 26 female, with a mean age of 37.4 ± 10.0 years, mild to moderate knee OA, and a mean defect size of 3.0 ± 1.7 cm2, were recruited at 8 medical centers according to the following criteria: radiographic mild to moderate knee OA (Kellgren-Lawrence grade 2 or 3); up to 3 treatable chondral/osteochondral defects (International Cartilage Repair Society grades 3 and 4) on the femoral condyles or trochlea; a total defect size ≤7 cm2; and no concurrent knee instability, severe axial malalignment, or systemic arthropathy. All patients were evaluated at baseline and at 6, 12, 18, and 24 months after implantation using the Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Documentation Committee (IKDC) subjective score. Additionally, magnetic resonance imaging (MRI) was performed to assess the amount of cartilage defect filling at the repaired site. Results: Significant improvement on all KOOS subscales was recorded from baseline (Pain: 49.6 ± 13.1; Activities of Daily Living [ADL]: 56.1 ± 18.4; Sport: 22.8 ± 18.8; Quality of Life [QoL]: 23.5 ± 16.5; Symptoms: 55.4 ± 19.9) to the 24 months’ follow-up (Pain: 79.5 ± 21.1 [ P < .001]; ADL: 84.1 ± 21.4 [ P < .001]; Sport: 60.8 ± 31.9 [ P < .001]; QoL: 54.9 ± 30.4 [ P < .001]; Symptoms: 77.7 ± 21.2 [ P < .001]). The IKDC subjective score showed a similar trend and improved from 37.8 ± 14.7 at baseline to 65.8 ± 23.5 at 24 months ( P < .001). MRI showed a significant increase in defect filling over time: up to 78.7% ± 25.3% of surface coverage after 24 months. Treatment failure requiring revision surgery occurred in 8 patients (9.3%). Conclusion: The use of an aragonite-based osteochondral scaffold in patients with JSLs and mild to moderate knee OA provided significant clinical improvement at the 24-month follow-up, as reported by the patients. These findings were associated with good cartilage defect filling, as observed on MRI.

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“…17 The higher density of aragonite identifies it as a good biomedical material and finds application in bone regenerative medicine. 18 Numerous studies demonstrated that aragonite characteristics depend on experimental conditions and synthesis protocols. Calcium chloride and sodium carbonate salt solutions are the raw materials, and later strontium, 19 lithium, 20 and bromide 21 were added to produce aragonite crystals.…”

Section: Introductionmentioning

confidence: 99%

Effect of the magnetic field produced by a Halbach array magnetizer on water UV absorption, removal of scale and change in calcium carbonate polymorphs

2022

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Cowries derived aragonite as raw biomaterials for bone regenerative medicine

Cited by 17 publications

References 18 publications

Análise comparativa do efeito de dois protocolos de ultrassom terapêutico para regeneração de defeito ósseo crítico

Análise comparativa do efeito de dois protocolos de ultrassom terapêutico para regeneração de defeito ósseo crítico

Aragonite-Based Scaffold for the Treatment of Joint Surface Lesions in Mild to Moderate Osteoarthritic Knees: Results of a 2-Year Multicenter Prospective Study

Effect of the magnetic field produced by a Halbach array magnetizer on water UV absorption, removal of scale and change in calcium carbonate polymorphs

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