The objectives of this work were to determine the effects of tillage depths, manure types, and the nature of their relationships with some performance indices and Grain Yield of red Cowpea (Vigna unguiculata L.). The experiment was laid out on a Split plot design; with Tillage depth (Zero, Shallow, and Deep Tillage) as main the plot, while Manure Type (No Manure, Cow Dung and Poultry Manure) was assigned to subplots. Upon analyses using R-Software, Plots treated with Poultry Manure showed the highest positive response compared to no manure and cow dung in terms of growth parameters, above ground biomass (523.3 Kgha-1), and Grain Yield (696.0 Kgha-1). Zero Tillage performed better than shallow and deep tillage. It was concluded that interaction between zero tillage and poultry manure proved the best to improve cowpea grain yield with value of (1063.8 Kgha-1), above ground biomass (766.7 Kgha-1), and can increase farmer's income and feed for their livestock. Pearson's Multiple Linear Correlation indicated high positive relationship between organic manure and all Cowpea parameters measured (r ≥ +0.65 ≤ +0.92). Tillage depth was found to significantly correlate with Pod length (r =-0.36*) and Single Pod Weight (r =-0.40*) at P ≤ 0.05 in a negative passion.