To my father and mother, who have sown the seed of learning in me and my siblings. I am profoundly grateful for all the time and love invested in me. Thank you for constantly provoking me to dream and supporting me to achieve.To my lovely wife, who has constantly been my strength and reason to seek improvement. You have been changing my life daily and for the better.To my siblings, Fernanda, Rafael, and Renata, I am blessed to have friends and partners such as you three; you are an inspiration to everything I have been doing.To my daughter, you are the joy of my life.
ACKNOWLEDGMENTSTo Dr. Davi Noboru Nakano, who patiently guided me into resuming my academic journey. He has been a valuable mentor, imparting invaluable knowledge and significantly contributing to my scientific and intellectual development.To my master's colleagues at PPGEP-USP, I am fortunate to have had the opportunity to work alongside such dedicated and talented individuals, and their impact on my academic journey is significant to me.