Cowdriosis/Heartwater

Stachurski, Frédéric; Gueye, Arona; Vachiéry, Nathalie

doi:10.1007/978-3-030-25385-1_22

Cited by 2 publications

(4 citation statements)

References 55 publications

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“…Ehrlichia ruminantium is a tick-borne rickettsia causing heartwater in domestic (goats, sheep, cattle) and wild (antelopes, giraffes, buffaloes) ruminants (Dumler et al, 2001). Among domestic animals, sheep and goats are more susceptible to heartwater than cattle, with high lethality (up to 80%) recorded in sheep (Stachurski et al, 2019). As the animals transferred from healthy to enzootic regions are highly susceptible (Adakal et al, 2002), heartwater heavily handicaps the genetic amelioration programs of African livestock.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, both R. microplus and the native West-African tick vector, Amblyomma variegatum, co-contribute to the bacterial transmission there (Some et al, 2023(Some et al, a, 2023. Aside this very recent situation, E. ruminantium is vectored to wildlife and domestic animals by African Amblyomma species with non-overlapping distribution, among which A. variegatum has got the largest geographical distribution (Stachurski et al, 2019). Preventing the transmission of E. ruminantium revealed to be difficult given the limits that were faced by several control approaches, ranging from tick control to livestock vaccination.…”

Section: Introductionmentioning

confidence: 99%

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Genetic structure of <i>Ehrlichia ruminantium</i> based on Multilocus Sequence Typing: particularities of strains from West-Africa

Biguezoton,

Adakal,

Farougou

et al. 2024

Int. J. Bio. Chem. Sci

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Ehrlichia ruminantium is the tick-borne rickettsia causing heartwater to wild and domestic ruminants. Previously, Multilocus Sequence Typing of this pathogen (MLST) highlighted the co-circulation of two genotypic groups within nearby villages from Burkina Faso where vaccination assays had been previously recurrently performed. In the present study the laboratory strains that had been involved in vaccination assays, which evidenced their close relationships with strains that were later involved in local outbursts, were genotyped. Characterization of the bacterium genetic diversity was extended to four distant Beninese localities where no vaccination assays had ever been performed, through sampling of N=500 specimens of the local tick vector, Amblyomma variegatum. This led evidencing an even higher frequency of new multilocus MLST genotypes in Benin than in Burkina Faso, 93% of the Beninese genotypes included at least one new private allele (i.e., no detected elsewhere), while this was only the case of 80% bacteria genotypes sampled in Burkina Faso. Investigating the genetic structure of the bacterium across the Africa continent revealed a reduction of its diversity in the eastern and southern part of the continent relatively to West Africa. As the bacterial genetic diversity currently remains highest in West Africa than anywhere else in the continent, this area remains optimal for the development and/or testing of vaccines against heartwater.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic structure of <i>Ehrlichia ruminantium</i> based on Multilocus Sequence Typing: particularities of strains from West-Africa

Biguezoton,

Adakal,

Farougou

et al. 2024

Int. J. Bio. Chem. Sci

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“…The death of a single animal can have dramatic consequences on a vulnerable household by reducing its ability to withstand food crisis and lift itself out of poverty (FAO, 2012). Heartwater disease, with its mortality rate of up to 80% in small ruminants (Stachurski et al, 2019) is one of the animal diseases causing this household vulnerability. It is caused by Ehrlichia ruminantium which is transmitted by Amblyomma spp ticks (Amblyomma variegatum in West Africa) (Jongejan and Uilenberg, 2004) with the acute form of the disease often found in susceptible animals (Stachurski et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…Heartwater disease, with its mortality rate of up to 80% in small ruminants (Stachurski et al, 2019) is one of the animal diseases causing this household vulnerability. It is caused by Ehrlichia ruminantium which is transmitted by Amblyomma spp ticks (Amblyomma variegatum in West Africa) (Jongejan and Uilenberg, 2004) with the acute form of the disease often found in susceptible animals (Stachurski et al, 2019). The infection rate determined in this tick-vector in West Africa is 9%-26% (Faburay et al, 2007;Farougou et al, 2012) and was assessed mainly in rural areas.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of heartwater disease in West Africa: similar infection rate of Ehrlichia ruminantium evidenced in adults of Amblyomma variegatum and Rhipicephalus microplus in peri-urban villages of Bobo-Dioulasso, Burkina Faso

Some¹,

Biguezoton²,

Zoungrana³

et al. 2023

Int. J. Bio. Chem. Sci

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Heartwater disease, is a virulent tick-borne disease of ruminants caused by Ehrlichia ruminantium (ER), biologically transmitted by Amblyomma spp. However, in West Africa, the potential of Rhipicephalus microplus (R. microplus) larvae to transmit this bacterium has been demonstrated. Although previous studies have been conducted on heartwater and ER in Burkina Faso, data on infection rate of the bacterium in A. variegatum and R. microplus is lacking in the peri-urban areas. Hence, this study aimed to compensate this gap, focusing on five peri-urban villages around 10-30 km from Bobo-Dioulasso. A total of 359 cattle was examined for ticks collection. However, only adult specimens of the two tick species collected on the same animals were included in the molecular detection of ER by semi-nested PCR. Results revealed a global contact rate of 19% in A. variegatum and 26% in R. microplus without a significant difference between these rates. Thus, while R. microplus invasion in West Africa is accompanied by the transmission of ER to animals, its contact rate with the causal agent of heartwater disease is similar to that with the previous known vector. Such context could impact the heartwater disease epidemiology, mainly in the peri-urban areas where the study was carried out. From previous knowledge and literature, that is the first time such study focusing on E. ruminantium infection rate in ticks in peri-urban areas is conducted. Results suggest the necessity to improve tick control methods in the study areas since both ticks species can transmit the causal agent of heartwater disease to animals.

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Cowdriosis/Heartwater

Cited by 2 publications

References 55 publications

Genetic structure of <i>Ehrlichia ruminantium</i> based on Multilocus Sequence Typing: particularities of strains from West-Africa

Genetic structure of <i>Ehrlichia ruminantium</i> based on Multilocus Sequence Typing: particularities of strains from West-Africa

Epidemiology of heartwater disease in West Africa: similar infection rate of Ehrlichia ruminantium evidenced in adults of Amblyomma variegatum and Rhipicephalus microplus in peri-urban villages of Bobo-Dioulasso, Burkina Faso

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