Cow's milk allergy in a patient with hyper-IgE syndrome

Hernandez-Trujillo, Vivian; Nguyen, William; Belleau, J.T.; Jeng, Michael; Conley, Mary Ellen

doi:10.1016/s1081-1206(10)61785-1

Cited by 8 publications

(12 citation statements)

References 22 publications

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“…The population included consisted exclusively of children aged 2 days to 12 years. The diagnosis of CMA was confirmed in 10 reports: four RCTs [10, 33–35] and six non‐RCTs [39–41, 43, 46, 47]. Ten other studies included subjects with suspected CMA: two RCTs [8, 30], and eight non‐RCTs [31, 32, 36–38, 42, 44, 45].…”

Section: Resultsmentioning

confidence: 99%

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The efficacy of amino acid‐based formulas in relieving the symptoms of cow's milk allergy: a systematic review

Hill

Murch

Rafferty³

et al. 2007

Clin Experimental Allergy

115

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The aim of this systematic review was to evaluate the efficacy of amino acid-based formulas (AAF) in patients with cow's milk allergy (CMA). Studies were identified using electronic databases and bibliography searches. Subjects eligible for inclusion were patients of any age with CMA or symptoms suggestive of it. Comparisons of interest were AAF vs. extensively hydrolysed formula (eHF), AAF vs. soy-based formula (SF) and AAF vs. cow's milk or cow's milk-based formula. Outcomes of interest were gastrointestinal (GI), dermatological, respiratory and behavioural symptoms as well as growth. A total of 20 studies [three head-to-head randomized controlled trials (RCTs), three cross-over challenge RCTs, seven clinical trials (CTs) and seven case reports (CRs)] were included in the review. In infants with confirmed or suspected CMA, the use of an AAF was shown to be safe and efficacious. Findings from RCT comparisons of AAF with eHF showed that both formulas are equally efficacious at relieving the symptoms of CMA in confirmed or suspected cases. However, infants in specific subgroups (e.g. non-IgE mediated food-induced gastro-enterocolitis-proctitis syndromes with failure to thrive, severe atopic eczema, or with symptoms during exclusive breastfeeding) were more likely overall to benefit from AAF, as intolerance to eHF may occur. In such cases, symptoms persisting despite eHF feeding usually remit on AAF, and catch-up growth may be seen. Meta-analysis of the findings was not possible due to lack of homogenous reporting of outcomes in the original trials. This systematic review shows clinical benefit from use of AAF in both symptoms and growth in infants and children with CMA who fail to tolerate eHF. Further studies are required to determine the relative medical or economic value of initial treatment with AAF in infants at high risk of eHF intolerance.

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Section: Resultsmentioning

confidence: 99%

“… RCTs: n =6; [8, 10, 33–35, 44] CCTs: none were identified CTs: n =7; [30–32, 36–38, 42] CRs: n =7; [39–41, 43, 45–47] …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy of amino acid‐based formulas in relieving the symptoms of cow's milk allergy: a systematic review

Hill

Murch

Rafferty³

et al. 2007

Clin Experimental Allergy

115

View full text Add to dashboard Cite

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“…Boos et al did not find significant increases in allergen-specific IgE to a large number of allergens, nor increased skin prick test positivity in patients with AD-HIES; this was in contrast to patients with AR-HIES due to mutations in DOCK8, who had IgE-mediated food allergies. 26,27 The diminished allergic diathesis in patients with AD-HIES has been attributed to potential impairment of mast cell and basophil degranulation in the context of dominant negative STAT3 mutations. 28 …”

Section: Discussionmentioning

confidence: 99%

Autosomal Dominant Hyper-IgE Syndrome in the USIDNET Registry

Gernez

Freeman

Holland

et al. 2018

The Journal of Allergy and Clinical Immunology: In Practice

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BACKGROUND Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare condition. OBJECTIVE Data from the USIDNET Registry provide a resource to examine the characteristics of patients with rare immune deficiency diseases. METHODS A query was submitted to the USIDNET requesting deidentified data for patients with physician-diagnosed AD-HIES through July 2016. RESULTS Data on 85 patients diagnosed with AD-HIES (50 males; 35 females) born between 1950 and 2013, collected by 14 physicians from 25 states and Quebec, were entered into the USIDNET Registry by July 2016. Cumulative follow-up was 2157 years. Of these patients, 45.9% had a family history of HIES. The complications reported included skin abscesses (74.4%), eczema (57.7%), retained primary teeth (41.4%), fractures (39%), scoliosis (34.1%), and cancer (7%). Reported allergic diseases included food (37.8%), environmental (18%), and drugs (42.7%). The mean serum IgE level was 8383.7 kU/mL and was inversely correlated to the patient’s age. A total of 49.4% had eosinophilia; 56% were known to be on trimethoprim-sulfamethoxazole, 26.6% on antifungal coverage, and 30.6% on immunoglobulin replacement therapy. Pneumonias were more commonly attributed to Staphylococcus aureus (55.3%) or Aspergillus fumigatus (22.4%); 19.5% had a history of lung abscess; these were most often associated with Pseudomonas aeruginosa (P Fisher’s exact test = .029) or A. fumigatus (P Fisher’s exact test = .016). Lung abscesses were significantly associated with drug reactions (P χ2 = .01; odds ratio: 4.03 [1.2–12.97]), depression (P Fisher’s exact test = .036), and lower Karnofsky index scores (P Mann-Whitney = .007). DISCUSSION Data from the USIDNET Registry summarize the currently reported clinical characteristics of a large cohort of subjects with AD-HIES.

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“…Most HIES patients do not have food allergy. However, true cases of atopic dermatitis (AD) may occur in HIES, as demonstrated by the recent report of three HIES patients who presented with growth retardation, eczema and severe allergy to cow's milk proteins and other food allergens, that responded to elimination of allergens from the diet, in combination with antibiotics and immune suppression 3-5. This contrasts with the inefficacy of diet in most patients with the atypical eczema that is characteristic of HIES, indicating significant pathophysiology differences with AD.…”

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confidence: 99%