Cow’s milk allergy: From allergens to new forms of diagnosis, therapy and prevention

Hochwallner, Heidrun; Schulmeister, Ulrike; Swoboda, Ines; Spitzauer, Susanne; Valenta, Rudolf

doi:10.1016/j.ymeth.2013.08.005

Cited by 194 publications

(191 citation statements)

References 225 publications

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“…Prospective studies, performed in various countries, showed that about 2.5% of children in the first year of life have allergic reactions to cow's milk, which is therefore considered the main cause of allergies in children [12].…”

Section: Cow's Milk Protein Allergymentioning

confidence: 99%

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

et al. 2017

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Donkey milk could be considered a good and safer alternative, compared to other types of milk, for infants affected by cow's milk protein allergy, when breastfeeding is not possible. Interestingly, donkey milk has low allergenicity, mainly due to the low total casein amount, and the content of some whey proteins that act as bioactive peptides. The amount of lysozyme, an antibacterial agent, is 1.0 g/L, similar to human milk. Lactoferrin content is 0.08 g/L, with this protein being involved in the regulation of iron homoeostasis, anti-microbial and anti-viral functions, and protection against cancer development. Lactoperoxidase, another protein with antibacterial function, is present in donkey milk, but in very low quantities (0.11 mg/L). β-lactoglobulin content in donkey milk is 3.75 g/L-this protein is able to bind and transport several hydrophobic molecules. Donkey milk's α-lactalbumin concentration is 1.8 g/L, very close to that of human milk. α-lactalbumin shows antiviral, antitumor, and anti-stress properties. Therefore, donkey milk can be considered as a set of nutraceuticals properties and a beverage suitable, not only for the growing infants, but for all ages, especially for convalescents and for the elderly.

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Section: Cow's Milk Protein Allergymentioning

confidence: 99%

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

et al. 2017

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“…Atopic dermatitis is a major manifestation of this allergy (Botteman and Detzel 2015). Respiratory allergies include asthma, rhinitis, wheezing, coughing, and laryngeal edema (Hochwallner et al 2014). Gastrointestinal upsets like diarrhea, abdominal pain, nausea, vomiting are observed (Kattan et al 2011).…”

Section: Quality Improvement/combination With Other Supplementmentioning

confidence: 99%

Emerging trends in nutraceutical applications of whey protein and its derivatives

Patel

2015

J Food Sci Technol

121

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The looming food insecurity demands the utilization of nutrient-rich residues from food industries as valueadded products. Whey, a dairy industry waste has been characterized to be excellent nourishment with an array of bioactive components. Whey protein comprises 20 % of total milk protein and it is rich in branched and essential amino acids, functional peptides, antioxidants and immunoglobulins. It confers benefits against a wide range of metabolic diseases such as cardiovascular complications, hypertension, obesity, diabetes, cancer and phenylketonuria. The protein has been validated to boost recovery from resistance exercise-injuries, stimulate gut physiology and protect skin against detrimental radiations. Apart from health invigoration, whey protein has proved its suitability as fat replacer and emulsifier. Further, its edible and antimicrobial packaging potential renders its highly desirable in food as well as pharmaceutical sectors. Considering the enormous nutraceutical worth of whey protein, this review emphasizes on its established and emerging biological roles. Present and future scopes in food processing and dietary supplement formulation are discussed. Associated hurdles are identified and how technical advancement might augment its applications are explored. This review is expected to provide valuable insight on whey protein-fortified functional foods, associated technical hurdles and scopes of improvement.

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“…The panel of pollen allergens contained allergens useful for the identification of the genuine sensitizing pollen species as well as cross-reactive allergens [53,54]. Furthermore, attempts were made to include relevant food allergens from, e.g., nuts, peanuts, milk and several other allergen sources [55][56][57][58][59]. Column "CCD" (cross-reactive carbohydrate determinants) in Table 1 indicates glycosylated allergen molecules with confirmed reactivity to CCD-specific IgE.…”

Section: Examples Of Detecting Early Allergen-specific Ige Responses mentioning

confidence: 99%

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

Lupinek

Wollmann

Baar

et al. 2014

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219

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Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the effect of therapies on the immune response to individual allergen molecules. Allergen microarrays contain a large variety of allergen molecules and thus allow the simultaneous detection of allergic patients' antibody reactivity profiles towards each of the MeDALL is a European research program in which allergen microarray technology is used for the monitoring of the development of allergic disease in childhood, to draw a geographic map of the recognition of clinically relevant allergens in different populations and to establish reactivity profiles which are associated with and predict certain disease manifestations. We describe technical advances of the MeDALL allergen-chip regarding specificity, sensitivity and its ability to deliver test results which are close to in vivo reactivity. In addition, the usefulness and numerous advantages of allergen microarrays for allergy research, refined allergy diagnosis, monitoring of disease, of the effects of therapies, for improving the prescription of specific immunotherapy and for prevention are discussed. Europe PMC Funders Group

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Cow’s milk allergy: From allergens to new forms of diagnosis, therapy and prevention

Cited by 194 publications

References 225 publications

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

Emerging trends in nutraceutical applications of whey protein and its derivatives

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

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