Cow's milk allergic children—Can component‐resolved diagnostics predict duration and severity?

Petersen, Thomas Houmann; Mørtz, Charlotte G.; Bindslev‐Jensen, Carsten; Eller, Esben

doi:10.1111/pai.12854

Cited by 33 publications

(24 citation statements)

References 26 publications

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“…Milk component proteins have been previously shown to have some utility in identifying patients with persistent or more severe cow's milk allergy, 38 and baseline levels of IgE specific to milk, caseins, and b-lactoglobulin had significant association with SU outcome of MOIT when adjusted for the adjuvant treatment group. 17 However, the epitope-specific IgE model outperformed the best model using only standard laboratory data (ie, SCP-specific IgE, IgG, and IgG 4 ; AUC 5 0.80 and accuracy 5 80%).…”

Section: Discussionmentioning

confidence: 99%

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles

Suárez‐Fariñas

Suprun

Chang

et al. 2019

Journal of Allergy and Clinical Immunology

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Section: Discussionmentioning

confidence: 99%

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles

Suárez‐Fariñas

Suprun

Chang

et al. 2019

Journal of Allergy and Clinical Immunology

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“…For example, children with higher levels of IgE to cow's milk allergens in PAMD@ had a higher risk for persisting milk allergy. 178 Using PAMD@, the IgE/IgG4 ratio and the sIgE sensitization pattern allowed the discrimination of patients with cow's milk allergy who tolerate cooked milk. 179 However, further PAMD@ studies are needed to predict tolerance, with the hope of being able to reduce the need for food challenges.…”

Section: Milkmentioning

confidence: 99%

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Ansotegui¹,

Melioli²,

Canonica³

et al. 2020

World Allergy Organization Journal

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Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from more than 50 allergy sources are commercially available for in vitro specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal of new information has become available regarding this topic, with over 100 publications in the last year alone. It thus seems quite reasonable to publish an update. It is imperative that clinicians and immunologists specifically trained in allergology keep abreast of the new and rapidly evolving evidence available for PAMD@. PAMD@ may initially appear complex to interpret; however, with increasing experience, the information gained provides relevant information for the allergist. This is especially true for food allergy, Hymenoptera allergy, and for the selection of allergen immunotherapy. Nevertheless, all sIgE tests, including PAMD@, should be evaluated within the framework of a patient's clinical history, because allergen sensitization does not necessarily imply clinical relevant allergies.

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“…36 Component-resolved diagnostics are promising tools for diagnosing FA and may predict duration and severity of cow's milk allergy. 37 In 78 children, it was found that OFC cannot be replaced by sIgE to whole milk protein or milk components nor skin prick tests in the diagnosis of cow's milk allergy. However, high levels of milk components and sIgE to milk increase the risk of a long-lasting or persisting cow's milk allergy.…”

Section: Food Challengesmentioning

confidence: 99%

Food and drug allergy, and anaphylaxis in EAACI journals (2018)

Eigenmann

Akdiş²,

Bousquet

et al. 2019

Pediatric Allergy Immunology

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: "Allergy," "Pediatric Allergy and Immunology (PAI)," and "Clinical and Translational Allergy (CTA)." One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. This paper summarizes the achievements of 2018 in anaphylaxis, and food and drug allergy. Main topics that have been focused are anaphylaxis, mechanisms of food allergy (FA), epidemiology of FA, food allergens, diagnosis of FA, prevention and control of FA, FA immunotherapy, drug allergy, and political agenda. K E Y W O R D S allergy, anaphylaxis, Clinical and Translational Allergy, drug allergy, European Academy of Allergy and Clinical Immunology, food allergy, hypersensitivity, Pediatric Allergy and Immunology

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Cow's milk allergic children—Can component‐resolved diagnostics predict duration and severity?

Abstract: Oral food challenge cannot be replaced by s-IgE to whole milk protein or milk components nor SPT in the diagnosis of CMA; however, high levels of milk components and s-IgE to milk increase the risk of a long-lasting or persisting CMA.

Cited by 33 publications

References 26 publications

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles

Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles

A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020

Food and drug allergy, and anaphylaxis in EAACI journals (2018)

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