COVISHIELD (AZD1222) VaccINe effectiveness among healthcare and frontline Workers of INdian Armed Forces: Interim results of VIN-WIN cohort study

Ghosh, Sutanu; Shankar, Subramanian; Chatterjee, Kaushik; Yadav, Arun Kumar; Pandya, Kapil; Suryam, Vani; Agrawal, Sunil; Ray, Subrata Basu; Phutane, Vivek H.; Datta, R. Κ.

doi:10.1016/j.mjafi.2021.06.032

Cited by 51 publications

(45 citation statements)

References 17 publications

(22 reference statements)

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“…Comparison with other studies is mentioned in Table 4. In our study, the median days between the second dose and being tested positive for SARS-CoV-2 was 65 days which is much longer than reported in all the previous studies, which ranged from 5 days or 47 days [9,12,15,16]. Also, none of the vaccinated HCWs who tested positive for SARS-CoV-2 were hospitalized, and there were no deaths, which in turn proves that vaccination reduces hospitalization by 100% which is more than the results observed in a study conducted in Scotland (88%) [18] and England (43%) [19].…”

Section: Resultscontrasting

confidence: 45%

“…The linear forecast (dotted line) graph (Figure 2), shows that the probability of getting infected in vaccinated HCPs is comparatively less than the unvaccinated group. Completing the full course of the vaccination decreased the risk of infection with the SARS-CoV-2 virus by 84.96% which is lower than the 91.8 -94.9% in the VIN-WIN cohort [12] and the study done by Benal JL et.al i.e, 89% (85% to 93%) [13].…”

Section: Resultsmentioning

confidence: 70%

“…Of this population, 243 (75%) completed the full primary cycle of vaccination, i.e., completed 14 days post-vaccination with 2 doses of ChAdOx1 nCoV-19 vaccine, and 80 (25%) were not vaccinated. Reasons for not being vaccinated (80) include breastfeeding 33.75% (27), pregnancy 13.75% (11), expecting pregnancy 15% (12), previous history of allergic reactions 0.0375% (3), and vaccine hesitancy 33.75% (27).…”

Section: Resultsmentioning

confidence: 99%

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SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

Issac¹,

Kochuparambil²,

Elizabeth³

2021

Preprint

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Objective: The national COVID-19 vaccination campaigns in India, prioritized healthcare workers to be vaccinated with ChAdOx1 nCoV-19 (AZD1222). So, we aimed to ascertain the effectiveness of the ChAdOx1 nCoV-19 vaccine among the healthcare workers by characterizing the breakthrough infections which occurred 14 days after the second dose of the vaccine. Methods: We prospectively evaluated the Institutional Covid Vaccination Database to categorize the SARS-CoV-2 positive healthcare workers into 2 cohorts: infected vaccinated and infected unvaccinated cohort. Along with comparing the descriptive statistics of the cohorts, the relative risk (RR), relative risk reduction (RRR), and the vaccine effectiveness were calculated. The study population was compared for the significant difference by using the parametric model (binary logistic regression) for the Odds ratio and the non-parametric model (cox proportionality model) for the Hazard ratio. Results: Out of the 324 healthcare workers employed in our institution 243 (75%) were vaccinated. When 6.58% (16) of the vaccinated healthcare workers were tested positive, 43.75% (35) were infected in the unvaccinated cohort and the median time of infection in the vaccinated cohort was 65 days (range 20 - 91 days). While the cox proportionality model reveals that the age, sex, and the contact exposure status of the cohort are not significant factors for getting infected after being vaccinated, binary logistic regression proves that a significant relationship exists between the incidence of infection and the unvaccinated status (p = 0.001, OR = 4.278). Completing the two-dose of vaccination decreased the hazard of testing positive for the SARS-CoV-2 by 84.96 % when compared with the unvaccinated individuals, which is the effectiveness of the ChAdOx1 nCoV-19 vaccine. Conclusion: There is an increased risk of the third wave of COVID-19 infection in the upcoming months. So, primary infection control measures should be followed even if vaccinated, to prevent the risk of breakthrough infections.

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Section: Resultscontrasting

confidence: 45%

Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 99%

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SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

Issac¹,

Kochuparambil²,

Elizabeth³

2021

Preprint

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“…respectively [9]. A large-scale study in India armed forces following completed Covishield vaccine revealed nearly 93% reduction in prevalence of Covid infections; and, reduction in COVID-related deaths by 98% [9]. Breakthrough infections were found to be related with COVID-19 variant of concern [10].…”

Section: Introductionmentioning

confidence: 99%

Breakthrough Infection among Fully Vaccinated Physicians Working in COVID-19 Treatment Centers; Prevalence, Presenting Symptoms, Co-Morbidities and Outcome in the Third Wave of Epidemics in Myanmar

Pyar¹,

Hla²,

Aung³

et al. 2021

J Biomed Res Environ Sci

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Background: Coronavirus Disease 2019 (COVID-19), emerged in China at the end of 2019, became a major threat to health around the world. Breakthrough infection following COVID-19 vaccine has clinical and public health significance. The highest groups at risk of infection during the COVID-19 pandemic is health care workers; the physicians are the frontline workers. This study aimed to assess the prevalence of breakthrough COVID-19 infection and their clinical presentation, co-morbidities and outcome among physicians who were fully vaccinated, working in COVID-19 treatment centers in Myanmar. Methods: A cross-sectional descriptive study was conducted among physicians, at least 14 days after receiving second dose, working at COVID-19 treatment centers in Myanmar, during the third wave from end of May to August 2021. Data were collected by using standardized forms and analysis was done. Results: Among 410 physicians, 98.2% (221/225) received two dose of vaccination: Covaxin 90.0%, Covishield 9.5% and Sputink V 0.5%. They received first dose of vaccine in January/February 2021 and second dose in March/April 2021. In Myanmar, third wave started in end of May; the largest pandemic surge had reached its peak in July, 2021. In the third wave, most of them 72.9% (161/221) did not experience no infection. The prevalence of fully vaccinated break through infection was 27.1% (60/221); the majority 78.3% (47/60) were mild symptomatic infection. Severe infection was seen in 10% of physicians with breakthrough infection who required hospital admission and oxygen therapy. The common presenting symptoms in order of frequency were body aches and pain 62.6%, sneezing 56.6%, headache 53.5%, cough 52.5%, sore throat 45.5%, anosmia 33.3%, runny nose 23.2% and loose motion 27.3%. The uncommon symptoms were dyspnoea 9.1%, vertigo 6.1%, skin rash 5.1%, vomiting 5.1%, petechiae 3.0%, tinnitus 3.0% and silent hypoxia 3.0%, and non-per-os 1%. Most of them did not have any significant comorbidities. One out of six physicians having severe infection had diabetes mellitus and two were obese. The mean duration of hospital stay was 7 days. None of the cases was fatal. Conclusions: In this study, over 98% of physicians were fully vaccinated; majority with Covaxin. One in four physicians had breakthrough infection in third wave; mainly mild form. Nearly half of them had possible delta symptoms; aches and pain, sneezing, runny nose, headache, cough, and sore throat. Awareness of rare but important symptoms like Non-per-Os and vertigo should be highlighted both to public and health care personnel. Ten percent of physicians with breakthrough infection were severe. Mortality rate was zero.

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“…Victor et al had documented that the protective effect of covid vaccination in preventing infection, hospitalization, need for oxygen and ICU admission were 65%, 77%, 92% and 94% respectively[12]. VIN-WIN cohort study conducted among 1.59 million health care workers and frontline workers of Indian Armed Forces showed a 93% reduction in breakthrough infection following Covishield vaccination[13]. Ella et al[5], Voysey et al[4] had also documented the protective effect of the vaccine in preventing infection.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of vaccination in preventing severe SARS CoV-2 infection in South India-a hospital-based cross-sectional study

Ruban

Mohamed

Kalyanaraman

2021

Preprint

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Background & objectives: Establishing concrete evidence on effect of vaccination on severity of SARS CoV-2 infections in real world situations is the need of the hour. The aim of this study is to estimate the effectiveness Covid 19 vaccines in preventing the new and severe SARS CoV-2 infections. Methods: We did this retrospective cross-sectional study among the 4765 patients consecutive adult inpatients admitted in the Covid 19 wards of a tertiary care hospital from May 1,2021 to July 7, 2021 during the second wave of Covid 19 pandemic. Information on basic demographic variables, RT PCR status, vaccination status, outcome and clinical severity of illness were obtained from the electronic hospital patient records. Results, and Interpretation & conclusions: Type of vaccine and number of doses of vaccines didnot have any protective effect against new SARS CoV-2 infection. Covid 19 patients vaccinated with at least one dose had 75 % less risk of requiring oxygen (OR 0.25 CI: 0.15 to 0.44) and 60 % less risk of ICU admission (OR 0.4 CI: 0.2 to 0.6) and it was statistically significant. Only 31 % of fully vaccinated Covid 19 positive patients had oxygen requirement (90% less risk) and 15% of the fully vaccinated patients had needed ICU admission (90% less risk). Conclusion: Vaccination didnot protect against SARS Cov-2 infection however significant protection was documented against severe SARS Cov-2 infection. Vaccination coverage should be increased urgently in order to halt the impending wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

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COVISHIELD (AZD1222) VaccINe effectiveness among healthcare and frontline Workers of INdian Armed Forces: Interim results of VIN-WIN cohort study

Cited by 51 publications

References 17 publications

SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

SARS-CoV-2 Breakthrough Infections among the Healthcare Workers Post-Vaccination with ChAdOx1 nCoV-19 Vaccine in the South Indian State of Kerala

Breakthrough Infection among Fully Vaccinated Physicians Working in COVID-19 Treatment Centers; Prevalence, Presenting Symptoms, Co-Morbidities and Outcome in the Third Wave of Epidemics in Myanmar

Effectiveness of vaccination in preventing severe SARS CoV-2 infection in South India-a hospital-based cross-sectional study

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