COVID-PIRO (Predisposition, Insult, Response, Organ Dysfunction) Score: A Reliable Predictor of Outcomes in COVID-19 Patients Admitted in Intensive Care Unit

Abstract

IntroductionTo measure the severity of sepsis and pneumonia in adult patients with coronavirus disease 2019 , the PIRO model (predisposition, insult, response, organ dysfunction) was adopted as a scoring system. In this study, the PIRO model was modified to classify the severity of pneumonia in adults and predict mortality risk infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), admitted to a tertiary intensive care unit (ICU) in central rural India. MethodThis prospective, observational study was conducted in the Department of Medicine, in rural medical college at Wardha, Maharashtra, India from May 2020 to May 2021. Patients with reverse transcription-polymerase chain reaction (RT-PCR) positive for COVID-19 and whose age was more than 18 years admitted in the intensive care unit were included in the study. ResultsA total of 240 patients were included in the analysis having mean age of 60.27 ± 15.3 years. Number of deaths were 115 out of 240 (48.3%). Mean ICU stay was 9.09 ± 6.34 days. PIRO score ≤14.5 had a mortality rate of 1.25% as compared to the group having PIRO>14.5 which had mortality of 27.5%, with a cure rate of 26.25% and 5% respectively in both groups (p = 0.0001). ConclusionCOVID-PIRO modified PIRO score was a highly sensitive and specific model in predicting in-hospital mortality but it is moderately sensitive in predicting ICU stay.

Role of Zinc and Clinicopathological Factors for COVID-19-Associated Mucormycosis (CAM) in a Rural Hospital of Central India: A Case-Control Study

“…Presently, many studies have been conducted to detect potent markers of severity for COVID-19 [16][17][18] and the effect of diabetes mellitus on COVID-19, leading to opportunistic infections [19]. However, there is a sparsity of data to determine important factors like zinc for COVID-19-associated opportunistic infection, such as mucormycosis, making the topic of this study important for public health.…”

Association of serum ferritin with COVID-19 in a cross-sectional study of 200 intensive care unit patients in a rural hospital

“…In a study conducted by Kumar S et al . [ 10 ] it was seen serum ferritin corelated with the severity of COVID-19 infection by a scoring system- PIRO scoring.…”

“…During such times, carrying out simple serum ferritin test could help us understand the severity of COVID-19, its probable association with HRCT score and the related morbidity and mortality. [ 10 ] Hence, ferritin can prove pivotal in a rural setting.…”