COVID-19: аn Update on the Modern Etiotropic Therapy Methods for the New Coronavirus Infection

Abstract

COVID-19 pandemic, caused by SARS-CoV-2 RNA-virus, has a huge impact not only on a peoples lifestyle, but a worldwide economy as well. According to the epidemiological data amongst Russian Federation the highest level of the sickness rate was in January-February of 2022, while the death rate was 1,9. The therapy methods of curing COVID-19 are being developed as the plenty of clinical studies are being held. Despite that fact there are plenty of important questions remaining unsolved regarding clinical usage of abundance of entirely new or repurposed drugs. One thing for sure - the most effective way of preventing the immune system from developing hyperactive reaction known as cytokine storm is prescribing etiotropic therapy as faster as possible. Etiotropic drugs are divided into three large groups: ones preventing the virus from penetrating the cell, ones affecting replication-transcriptional complex and last but not least - ones with direct or indirect cytotoxic effect. This review introduces some actual data regarding etiotropic treatment methods of the novel coronavirus disease.