COVID-19: Way Forward With Serosurveillance Without Overemphasizing Neutralizing Antibodies

Kršák, Martin; Henao-Martínez, Andrés F; Franco‐Paredes, Carlos

doi:10.1089/vim.2020.0246

Cited by 2 publications

(3 citation statements)

References 35 publications

(37 reference statements)

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“…Serosurveillance of malaria offers the advantage of making known active transmission in cases that would otherwise be deemed as interrupted transmission [20]. A case example was observed in Ghana where the parasite prevalence was well below 5% throughout the year, whereas an equivalent seroprevalence of mosquito salivary protein gSG6-P1 and Plasmodium falciparum merozoite surface protein MSP1 19 were above 40% (Figure 1) [21]. A similar observation was made in a study in Somalia where the prevalences of MSP1 19 were 17.9% and 19.3% in the wet and dry seasons respectively when no parasites had previously been observed [20].…”

Section: Seroprevalence As Malaria Transmission Metric For Surveillancementioning

confidence: 99%

“…Seroprevalence helps to overcome the challenge of subpatent malaria since microscopy and rapid diagnostic test (RDT) used to measure parasite prevalence Relationship between malaria parasite prevalence and antigen specific seroprevalence (adapted from Badu et al 2015) [21].…”

Section: Seroprevalence As Malaria Transmission Metric For Surveillancementioning

confidence: 99%

“…Figure 1.Relationship between malaria parasite prevalence and antigen specific seroprevalence (adapted fromBadu et al 2015) [21].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Malaria Elimination: The Role and Value of Sero-Surveillance

Badu¹,

Larbi²,

Boampong³

2021

Current Topics and Emerging Issues in Malaria Elimination

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As countries move from intense malaria transmission to low transmission there will be a demand for more sensitive tools and approaches in tracking malaria transmission dynamics. Surveillance tools that are sensitive in tracking real time infectious bites as well as infectious reservoir will be preferred to counting number of cases in the hospital or parasite prevalence. The acquisition and maintenance of anti-malarial antibodies is a direct function of parasite exposure, seroprevalence rates has been used as an efficient tool in assessing malaria endemicity and confirming malaria elimination. Plasmodium antibodies are explicit biomarkers that can be utilised to track parasite exposure over more extensive time spans than microscopy, rapid diagnostic testing or molecular testing and the conventional entomological inoculation rate. Seroprevalence studies can therefore help monitor the impact of malaria control interventions, especially when the parasite occurrence is low. As a result, antibody responses to Anopheles salivary proteins or Plasmodium species may potentially offer reliable information of recent or past exposure; recognise short-term or gradual changes in exposure to Plasmodium infection or to estimate individual-level exposure to infection. This book chapter will present about four studies we have conducted across eastern and western Africa on the efficiency of salivary gland proteins and antimalarial antibodies in tracking malaria transmission intensity. We hope that these could be used as surveillance tools in malaria elimination efforts.

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Section: Seroprevalence As Malaria Transmission Metric For Surveillancementioning

confidence: 99%

Section: Seroprevalence As Malaria Transmission Metric For Surveillancementioning

confidence: 99%