“…Most of them concentrated on specific populations, such as children, asthmatics, or patients with mastocytosis, and thoroughly described allergic reactions. These were rather limited to a few thousand patients [ 18 , 19 , 20 , 21 , 22 , 23 ]. A few reports on large databases such as EV were published, though these concentrated mainly on anaphylaxis or anaphylactic shock as life-threatening reactions, which are easily coded in the database [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ].…”