COVID-19 vaccine uptake in mental healthcare users: Czech nationwide register study

Pisl, Vojtech; Vevera, Jan

doi:10.1016/j.vaccine.2023.07.028

“…While some studies have observed significantly lower uptake of COVID-19 vaccination among individuals with mental illness, (10,11) others have either reported higher uptake (12), no significant difference, (13) or differences in uptake according to the type of mental illness. (14)(15)(16) Additionally, little is currently known regarding the effect of psychiatric treatment on COVID-19 vaccination uptake. As a result, the relationship between mental illness and COVID-19 vaccination uptake may be more complex, and could differ depending on the type, severity, and treatment status of mental illness.…”

Section: Introductionmentioning

confidence: 99%

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Barker,

Kõiv,

Magnúsdóttir

et al. 2024

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Background: Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Therefore, we aimed to investigate the association between mental illness and COVID-19 vaccination uptake, using data from five countries. Methods: Data from seven cohort studies (N=325,298), and the Swedish registers (8,080,234), were used to identify mental illness and COVID-19 vaccination uptake. Multivariable modified Poisson regression models were conducted to calculate the prevalence ratio (PR) and 95% CIs of vaccination uptake among individuals with v.s. without mental illness. Results from the cohort studies were pooled using random effects meta-analyses. Findings: Most of the meta-analyses performed using the COVIDMENT study population showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first (prevalence ratio [PR]: 0.98, 95% CI: 0.98-0.99, p<0.001) and second dose among individuals with mental illness; the reduction was however greater among those not using pyschiatric medication (PR: 0.91, 95% CI: 0.91-0.91, p<0.001). Conclusions: The high uptake of COVID-19 vaccination observed among individuals with most types of mental illness highlights the comprehensiveness of the vaccination campaign , however lower levels of vaccination uptake among subgroups of individuals with unmedicated mental illness warrants attention in future vaccination campaigns.

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Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Barker,

Kõiv,

Magnúsdóttir

et al. 2024

Nat Commun

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Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Using data from seven cohort studies (N = 325,298) included in the multinational COVIDMENT consortium, and the Swedish registers (N = 8,080,234), this study investigates the association between mental illness (defined using self-report measures, clinical diagnosis and prescription data) and COVID-19 vaccination uptake. Results from the COVIDMENT cohort studies were pooled using meta-analyses, the majority of which showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first and second dose of a COVID-19 vaccine among individuals with vs. without mental illness; the reduction was however greater among those not using psychiatric medication. Here we show that uptake of the COVID-19 vaccine is generally high among individuals both with and without mental illness, however the lower levels of vaccination uptake observed among subgroups of individuals with unmedicated mental illness warrants further attention.

show abstract

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Barker,

Kõiv,

Magnúsdóttir

et al. 2024

Preprint

0

View full text Add to dashboard Cite

Background: Individuals with mental illness are at higher risk of severe COVID-19 outcomes. However, previous studies on the uptake of COVID-19 vaccination in this population have reported conflicting results. Therefore, we aimed to investigate the association between mental illness and COVID-19 vaccination uptake, using data from five countries. Methods: Data from seven cohort studies (N=325,298), and the Swedish registers (8,080,234), were used to identify mental illness and COVID-19 vaccination uptake. Multivariable modified Poisson regression models were conducted to calculate the prevalence ratio (PR) and 95% CIs of vaccination uptake among individuals with v.s. without mental illness. Results from the cohort studies were pooled using random effects meta-analyses. Findings: Most of the meta-analyses performed using the COVIDMENT study population showed no significant association between mental illness and vaccination uptake. In the Swedish register study population, we observed a very small reduction in the uptake of both the first (prevalence ratio [PR]: 0.98, 95% CI: 0.98-0.99, p<0.001) and second dose among individuals with mental illness; the reduction was however greater among those not using pyschiatric medication (PR: 0.91, 95% CI: 0.91-0.91, p<0.001). Conclusions: The high uptake of COVID-19 vaccination observed among individuals with most types of mental illness highlights the comprehensiveness of the vaccination campaign , however lower levels of vaccination uptake among subgroups of individuals with unmedicated mental illness warrants attention in future vaccination campaigns.

show abstract

COVID-19 vaccine uptake in mental healthcare users: Czech nationwide register study

Cited by 3 publications

References 51 publications

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

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COVID-19 vaccine uptake in mental healthcare users: Czech nationwide register study

Cited by 3 publications

References 51 publications

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data

Mental illness and COVID-19 vaccination: a multinational investigation of observational &amp; register-based data

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Mental illness and COVID-19 vaccination: a multinational investigation of observational & register-based data