COVID-19 vaccine does not affect male reproductive health (based on RNA-sequencing data)

The impact of COVID-19 vaccines on fertility-A systematic review and meta-analysis

“…After the screening process, 39 articles were considered pertinent for potential inclusion and the full texts were retrieved. Finally, 29 articles [1] , [2] , [3] , [4] , [6] , [7] , [8] , [10] , [15] , [17] , [18] , [20] ; Gonzalez et al, 2021; Huang et al, 2022; Jacobs et al, 2022; Lifshitz et al, 2022; Mohr-Sasson et al, 2022; Morris, 2021; Morris et al, 2021; Odeh‐Natour et al, 2022; Orvieto et al, 2021; Reschini et al, 2022; Rozhivanov & Mokrysheva, 2021; Safrai, Herzberg, et al, 2022; Safrai, Kremer, et al, 2022; Soysal & Yılmaz, 2022; Wesselink et al, 2022; Xia et al, 2022; Zhu et al, 2022)were included in the systematic review and 20 articles [2] , [3] , [4] , [6] , [7] , [18] , [20] ; Gonzalez et al, 2021; Huang et al, 2022; Jacobs et al, 2022; Morris, 2021; Odeh‐Natour et al, 2022; Orvieto et al, 2021; Reschini et al, 2022; Rozhivanov & Mokrysheva, 2021; Safrai, Herzberg, et al, 2022; Safrai, Kremer, et al, 2022; Soysal & Yılmaz, 2022; Xia et al, 2022; Zhu et al, 2022) in the meta-analysis ( Figure 1 ).

Figure 1 Flowchart of the screening and selection process

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“…After the selection process, 29 studies were included ( Figure 1 ): 10 (34.5%) were conducted in Israel [4] , [6] , [7] , [8] ; Lifshitz et al, 2022; Mohr-Sasson et al, 2022; Odeh‐Natour et al, 2022; Orvieto et al, 2021; Safrai, Herzberg, et al, 2022; Safrai, Kremer, et al, 2022), 7 (24.1%) in the USA [2] , [3] , [10] ; Gonzalez et al, 2021; Jacobs et al, 2022; Morris, 2021; Morris et al, 2021), 6 (20.7%) in Russia [1] , [15] , [17] , [18] , [20] ; Rozhivanov & Mokrysheva, 2021), 3 (10.3%) in China(Huang et al, 2022; Xia et al, 2022; Zhu et al, 2022), 1 (3.5%) in Italy (Reschini et al, 2022), 1 (3.5%) in North-America (Canada and USA)(Wesselink et al, 2022) and 1 (3.5%) in Turkey (Soysal & Yılmaz, 2022).…”

“…In 16 studies from Israel and USA [2] , [3] , [4] , [6] , [7] , [8] , [10] ; Gonzalez et al, 2021; Lifshitz et al, 2022; Mohr-Sasson et al, 2022; Morris, 2021; Morris et al, 2021; Odeh‐Natour et al, 2022; Orvieto et al, 2021; Safrai, Herzberg, et al, 2022; Safrai, Kremer, et al, 2022) , as well as the study from Turkey (Soysal & Yılmaz, 2022), the vaccines investigated were the two mRNA vaccines, BNT162b2 and mRNA-1273 (respectively, known as Pfizer and Moderna); the 6 studies from Russia (20.7%) [1] , [15] , [17] , [18] , [20] ; Rozhivanov & Mokrysheva, 2021) investigated the adenovirus-vector vaccine Gam-COVID-Vac (also known as Sputnik V); 3 studies from China (10.3%) (Huang et al, 2022; Xia et al, 2022; Zhu et al, 2022) investigated the inactivated vaccine (Sinopharm or Sinovac). In the other 3 studies from Italy, North America and USA, several vaccines were analysed (mRNA and viral vector based) (Jacobs et al, 2022; Reschini et al, 2022; Wesselink et al, 2022).…”

“…In total, 15 studies (51.7%) were conducted on female population [2] , [3] , [4] , [6] , [8] , [15] , [17] ; Huang et al, 2022; Jacobs et al, 2022; Mohr-Sasson et al, 2022; Morris, 2021; Morris et al, 2021; Odeh‐Natour et al, 2022; Safrai, Kremer, et al, 2022; Soysal & Yılmaz, 2022), 11 studies (37.9%) on males [1] , [7] , [10] , [18] , [20] ; Gonzalez et al, 2021; Lifshitz et al, 2022; Reschini et al, 2022; Rozhivanov & Mokrysheva, 2021; Safrai, Herzberg, et al, 2022; Zhu et al, 2022) and 3 studies (10.3%) included both populations(Orvieto et al, 2021; Wesselink et al, 2022; Zhu et al, 2022).…”

“…2 studies from Russia [15] , [17] , 1 from Turkey (Soysal & Yılmaz, 2022) and 1 from Israel (Mohr-Sasson et al, 2022) were conducted on healthy women (10.3%). As for the studies on males, 7 were conducted on healthy men [1] , [7] , [18] , [20] ; Gonzalez et al, 2021; Lifshitz et al, 2022; Zhu et al, 2022), 1 on two comparative groups of healthy and unhealthy men(Rozhivanov & Mokrysheva, 2021), 2 on men undergoing IVG or assisted reproduction technology (ART) technology(Reschini et al, 2022; Safrai, Herzberg, et al, 2022), and 1 on men from a big database [10] .…”