COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature

Jaiswal, Vikash; Mukherjee, Dattatreya; Peng Ang, Song; Kainth, Tejasvi; Naz, Sidra; Babu Shrestha, Abhigan; Agrawal, Vibhor; Mitra, Saloni; Ee Chia, Jia; Jilma, Bernd; Mamas, Mamas A.; Gebhard, Catherine; Postula, Marek; Siller-Matula, Jolanta M.

doi:10.1016/j.ijcha.2023.101280

Cited by 2 publications

(1 citation statement)

References 94 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 8 Unfortunately, adenovirus vector vaccines were associated with high reactogenicity and some lethal thrombotic events and have now been taken off the market. 9 , 10 Similarly, mRNA vaccines were associated with high reactogenicity and inflammatory myocarditis, 11 provided relatively short-lived protection, required frequent boosters, 12 were expensive and were not stable except at very low temperatures. This indicates that these newer technologies are not ideal pandemic solutions.…”

Section: Introductionmentioning

confidence: 99%

Clinical development of SpikoGen®, an Advax-CpG55.2 adjuvanted recombinant spike protein vaccine

Petrovsky

2024

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Clinical development of SpikoGen®, an Advax-CpG55.2 adjuvanted recombinant spike protein vaccine

Petrovsky

2024

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

Long-Term Prognosis of Patients With Myocarditis Attributed to COVID-19 mRNA Vaccination, SARS-CoV-2 Infection, or Conventional Etiologies

Semenzato,

Le Vu,

Botton

et al. 2024

JAMA

View full text Add to dashboard Cite

ImportanceAlthough patients with myocarditis after COVID-19 mRNA vaccination appear to have a good prognosis near hospital discharge, their longer-term prognosis and management remain unknown.ObjectiveTo study the cardiovascular complications of post–COVID-19 mRNA vaccination myocarditis and other types of myocarditis during an 18-month follow-up, as well as disease management based on a study of the frequency of medical procedures and drug prescriptions.Design, Setting, and ParticipantsIn this cohort study based on the French National Health Data System, all individuals aged 12 to 49 years hospitalized for myocarditis in France between December 27, 2020, and June 30, 2022, were identified.ExposureIndividuals were categorized as having postvaccine myocarditis (within 7 days after COVID-19 mRNA vaccine), post–COVID-19 myocarditis (within 30 days of SARS-CoV-2 infection), or conventional myocarditis.Main Outcomes and MeasuresThe occurrence of clinical outcomes (hospital readmission for myopericarditis, other cardiovascular events, all-cause death, and a composite outcome of these events) over the 18 months following hospital admission were analyzed using weighted Cox models to standardize the comparisons with the conventional myocarditis group. Also, medical management after hospital discharge was longitudinally assessed using generalized estimated equation models.ResultsIn total, 4635 individuals were hospitalized for myocarditis: 558 with postvaccine myocarditis, 298 with post–COVID-19 myocarditis, and 3779 with conventional myocarditis. Patients with postvaccine myocarditis were younger than those with post–COVID-19 and conventional myocarditis (mean [SD] age of 25.9 [8.6], 31.0 [10.9], and 28.3 [9.4] years, respectively) and were more frequently men (84%, 67%, and 79%). Patients with postvaccine myocarditis had a lower standardized incidence of the composite clinical outcome than those with conventional myocarditis (32/558 vs 497/3779 events; weighted hazard ratio, 0.55 [95% CI, 0.36-0.86]), whereas individuals with post–COVID-19 myocarditis had similar results (36/298 events; weighted hazard ratio, 1.04 [95% CI, 0.70-1.52]). The standardized frequency of medical procedures and drugs prescribed in patients with postvaccine myocarditis or post–COVID-19 myocarditis followed a similar trend in the 18 months following hospital discharge to that of patients with conventional myocarditis.Conclusions and RelevancePatients with post–COVID-19 mRNA vaccination myocarditis, contrary to those with post–COVID-19 myocarditis, show a lower frequency of cardiovascular complications than those with conventional myocarditis at 18 months. However, affected patients, mainly healthy young men, may require medical management up to several months after hospital discharge.

show abstract

COVID-19 vaccine-associated myocarditis: Analysis of the suspected cases reported to the EudraVigilance and a systematic review of the published literature

Cited by 2 publications

References 94 publications

Clinical development of SpikoGen®, an Advax-CpG55.2 adjuvanted recombinant spike protein vaccine

Clinical development of SpikoGen®, an Advax-CpG55.2 adjuvanted recombinant spike protein vaccine

Long-Term Prognosis of Patients With Myocarditis Attributed to COVID-19 mRNA Vaccination, SARS-CoV-2 Infection, or Conventional Etiologies

Contact Info

Product

Resources

About